Guided Probabilistic Topic Models for Agenda-setting and Framing

Probabilistic topic models are powerful methods to uncover hidden thematic structures in text by projecting each document into a low dimensional space spanned by a set of topics. Given observed text data, topic models infer these hidden structures and use them for data summarization, exploratory analysis, and predictions, which have been applied to a broad range of disciplines. Politics and political conflicts are often captured in text. Traditional approaches to analyze text in political science and other related fields often require close reading and manual labeling, which is labor-intensive and hinders the use of large-scale collections of text. Recent work, both in computer science and political science, has used automated content analysis methods, especially topic models to substantially reduce the cost of analyzing text at large scale. In this thesis, we follow this approach and develop a series of new probabilistic topic models, guided by additional information associated with the text, to discover and analyze agenda-setting (i.e., what topics people talk about) and framing (i.e., how people talk about those topics), a central research problem in political science, communication, public policy and other related fields. We first focus on study agendas and agenda control behavior in political debates and other conversations. The model we introduce, Speaker Identity for Topic Segmentation (SITS), is able to discover what topics that are talked about during the debates, when these topics change, and a speaker-specific measure of agenda control. To make the analysis process more effective, we build Argviz, an interactive visualization which leverages SITS's outputs to allow users to quickly grasp the conversational topic dynamics, discover when the topic changes and by whom, and interactively visualize the conversation's details on demand. We then analyze policy agendas in a more general setting of political text. We present the Label to Hierarchy (L2H) model to learn a hierarchy of topics from multi-labeled data, in which each document is tagged with multiple labels. The model captures the dependencies among labels using an interpretable tree-structured hierarchy, which helps provide insights about the political attentions that policymakers focus on, and how these policy issues relate to each other. We then go beyond just agenda-setting and expand our focus to framing--the study of how agenda issues are talked about, which can be viewed as second-level agenda-setting. To capture this hierarchical views of agendas and frames, we introduce the Supervised Hierarchical Latent Dirichlet Allocation (SHLDA) model, which jointly captures a collection of documents, each is associated with a continuous response variable such as the ideological position of the document's author on a liberal-conservative spectrum. In the topic hierarchy discovered by SHLDA, higher-level nodes map to more general agenda issues while lower-level nodes map to issue-specific frames. Although qualitative analysis shows that the topic hierarchies learned by SHLDA indeed capture the hierarchical view of agenda-setting and framing motivating the work, interpreting the discovered hierarchy still incurs moderately high cost due to the complex and abstract nature of framing. Motivated by improving the hierarchy, we introduce Hierarchical Ideal Point Topic Model (HIPTM) which jointly models a collection of votes (e.g., congressional roll call votes) and both the text associated with the voters (e.g., members of Congress) and the items (e.g., congressional bills). Customized specifically for capturing the two-level view of agendas and frames, HIPTM learns a two-level hierarchy of topics, in which first-level nodes map to an interpretable policy issue and second-level nodes map to issue-specific frames. In addition, instead of using pre-computed response variable, HIPTM also jointly estimates the ideological positions of voters on multiple interpretable dimensions

Chemical profiles and antibacterial activity of acetone extract of two Curcuma species from Vietnam

Curcuma thorelii Gagnep. and Curcuma cotuana Luu, Škorni?k. & H.?.Tr?n are the rare species only found in Southeast Asia. The present study was the first to explore the chemical compositions and antibacterial effects of the whole plant acetone extracts of these 2 species. Altogether 41 and 31 compounds have been identified in C. thorelii and C. cotuana extracts by gas chromatography/mass spectrometry. Accordingly, the C. thorelii extract contained (E)-labda-8(17),12-diene-15,16-dial (33.37%), vitamin E (12.33%), phytol (9.83%) as the major compounds while C. cotuana extract contained predominantly (E)-labda-8(17),12-diene-15,16-dial (14.58%), n-hexadecanoic acid (10.96%), 3,7,11,15-tetramethylhexadec-2-en-1-yl acetate (8.13%), ?-sitosterol (7.97%). In addition, results from disc diffusion assay have shown that C. thorelii acetone extract had inhibitory effects on 5 out of 10 pathogenic bacterial strains such as Bacillus cereus (ATCC 11778), Listeria monocytogenes (ATCC 19111), Staphylococcus aureus (ATCC 25923), S. aureus (ATCC 29213) and S. saprophyticus (BAA750) while C. cotuana acetone extract was found to be effective only against B. cereus. The obtained results showed that the acetone extracts of C. thorelii and C. cotuana possessed several valuable bioactive compounds as well as promising antibacterial activity, which place a good foundation for future pharmaceutical product development

Chemical profiles and biological activities of acetone extracts of nine Annonaceae plants

This study investigated the chemical components and bioactivities of acetone leaf extracts of nine Annonaceae plants collected in the Binh Chau-Phuoc Buu Nature Reserve, Vietnam. A total of 182 constituents were identified, with linolenic acid, diaeudesmin, germacrene D, 1-octadecenoic acid, 8-(3-octyl-2-oxiranyl)-1-octanol, oleic acid, and phenylmethyl ester being the major compounds. The antimicrobial activity of the extracts was evaluated using a disc diffusion assay. Eight of the nine extracts, except for the Mitrephora thorelii extract, showed an inhibition effect against Bacillus cereus and Staphylococcus aureus. The antioxidant activity of the extracts was determined using DPPH assay, and the cytotoxic activity was deter mined using SRB assay. The results showed that the acetone extracts of Artabotrys hexapetalus, Uvularia grandiflora, Polyalthia luensis, Xylopia pierrei, Sphaerocoryne affinis, Desmos cochinchinensis, Uvaria littoralis, Mitrephora thorelii, and Goniothalamus touranensis had significant activity with IC50 for the DPPH radical scavenging activity ranging from 18.56 to 702.33 μg/mL, and the IC50 for the cytotoxic effects ranged from 5.39 to 251.77 μg/mL. Overall, the results obtained provide experimental evidence for the potential use of these plants in medicine and other related fields

Neutron Yield from (γ, n) and (γ, 2n) Reactions following 100 MeV Bremsstrahlung in a Tungsten Target

The photonuclear reactions of (γ, xn) or (γ, xnp) types can be used to produce high-intensity neutron sources for research and applied purposes. In this work a Monte-Carlo calculation has been used to evaluate the production yield of neutrons from the (γ, n) and (γ, 2n) reactions following the bremsstrahlung produced by a 100 MeV electron beam on a tungsten target