TECHNICAL ASSESSMENT OF GAMMA-AMINO BUTYRIC ACID (GABA) PRODUCTION FROM RICE BRAN

This research focused on technical assessment of GABA production from rice bran through fermentation by Lactobacillus brevis. Influence of operating pressure on separation of GABA by nanofiltration membrane was investigated and 4 bar was suitable for the nanofiltration process. The purification of GABA by nanofiltration with constant feed volume was carried out and purity of GABA reached 4.8 folds, compared to feed, at 5 volumes of added water. At 40 of concentration factor in concentration of GABA solution by nanofiltration with full recycle of retentate, content of GABA reached 49.8 g/L. The production of GABA from defatted rice bran at pilot scale was carried out at 1,000 L/batch (equal to 200 kg of rice bran) of fermentation. Estimation of mass balance showed that, with 200 kg of defatted rice bran, 7.0 kg of GABA powder was obtained. Results indicated that, it is potential to produce GABA from rice bran through the fermentation by Lactobacillus brevis

Immunohistochemical expression of anaplastic lymphoma kinase in neuroblastoma and its relations with some clinical and histopathological features

Background Anaplastic lymphoma kinase (ALK) mutations have been identified as a prominent cause of some familial and sporadic neuroblastoma (NB). ALK expression in NB and its relationship with clinical and histopathological features remains controversial. This study investigated ALK expression and its potential relations with these features in NB. Methods Ninety cases of NB at the Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam from 01/01/2018 to 12/31/2021, were immunohistochemically stained with ALK (D5F3) antibody. The ALK expression and its relations with some clinical and histopathological features were investigated. Results The rate of ALK expression in NB was 91.1%. High ALK expression (over 50% of tumor cells were positive with moderate-strong intensity) accounted for 65.6%, and low ALK expression accounted for 34.4%. All the MYCN-amplified NB patients had ALK immunohistochemistry positivity, most cases had high ALK protein expression. The undifferentiated subtype of NB had a lower ALK-positive rate than the poorly differentiated and differentiated subtype. The percentages of ALK positivity were significantly higher in more differentiated histological types of NB (p = .024). There was no relation between ALK expression and: age group, sex, primary tumor location, tumor stage, MYCN status, clinical risk, Mitotic-Karyorrhectic Index, prognostic group, necrosis, and calcification. Conclusions ALK was highly expressed in NB. ALK expression was not related to several clinical and histopathological features. More studies are needed to elucidate the association between ALK expression and ALK gene status and to investigate disease progression, especially the oncogenesis of ALK-positive NB

Teambuilding in the time of COVID-19: A Zoom Play

Items include Abstract & Summary; Script; PowerPoint & Zoom recorded performance.Abstract This play brings to life the story of a group of professional and para-professional staff at York University Libraries as they build a new team and provide new services during a year-long COVID-19 lockdown. Creative use of technologies help them develop a sense of community and a renewed sense of purpose. Summary In a strange and scary time, exiled from their place of work, a group of (relative) strangers turn a wellbeing exercise into so much more.  Picture this: a threat invisible to the naked eye empties out an entire 60, 000-person campus; the library locks its door with an hour’s notice; and the people who like to help are sent home indefinitely.  How are they, the library people, going to survive, thrive and help the faculty and students now dispersed to the four corners of the world?  This short play will tell you how.   The pandemic shut down the old ways of communicating, BUT library services still had to be available. The professional and para-professional staff in the library overcame personal, technical and other challenges to build a new team that would serve its public.  BUT team building requires communication and trust. How was trust in the new team built in an online environment known for its comical awkwardness? The limitations of Zoom were turned into a strength: week by week, turn by turn, everyone got to speak and truly listen to their team members.  The common launching off point was a carefully selected video on skills building, library services, accessibility and diversity.  Video by video, varied insights meant that team members were visible to each other as fellow humans and co-workers! A team was born.  Learn what each player in this team did to make it come alive. Come by and watch: Team-building in the Time of COVID: A Play  

A dynamic generalized fuzzy multi-criteria croup decision making approach for green supplier segmentation.

Supplier selection and segmentation are crucial tasks of companies in order to reduce costs and increase the competitiveness of their goods. To handle uncertainty and dynamicity in the supplier segmentation problem, this research thus proposes a new dynamic generalized fuzzy multi-criteria group decision making (MCGDM) approach from the aspects of capability and willingness and with respect to environmental issues. The proposed approach defines the aggregated ratings of alternatives, the aggregated weights of criteria, and the weighted ratings by using generalized fuzzy numbers with the effect of time weight. Next, we determine the ranking order of alternatives via a popular centroid-index ranking approach. Finally, two case studies demonstrate the efficiency of the proposed dynamic approach. The applications show that the proposed appoach is effective in solving the MCGDM in vague environment

A New Modeling Approach for Spatial Prediction of Flash Flood with Biogeography Optimized CHAID Tree Ensemble and Remote Sensing Data

Flash floods induced by torrential rainfalls are considered one of the most dangerous natural hazards, due to their sudden occurrence and high magnitudes, which may cause huge damage to people and properties. This study proposed a novel modeling approach for spatial prediction of flash floods based on the tree intelligence-based CHAID (Chi-square Automatic Interaction Detector)random subspace, optimized by biogeography-based optimization (the CHAID-RS-BBO model), using remote sensing and geospatial data. In this proposed approach, a forest of tree intelligence was constructed through the random subspace ensemble, and, then, the swarm intelligence was employed to train and optimize the model. The Luc Yen district, located in the northwest mountainous area of Vietnam, was selected as a case study. For this circumstance, a flood inventory map with 1866 polygons for the district was prepared based on Sentinel-1 synthetic aperture radar (SAR) imagery and field surveys with handheld GPS. Then, a geospatial database with ten influencing variables (land use/land cover, soil type, lithology, river density, rainfall, topographic wetness index, elevation, slope, curvature, and aspect) was prepared. Using the inventory map and the ten explanatory variables, the CHAID-RS-BBO model was trained and verified. Various statistical metrics were used to assess the prediction capability of the proposed model. The results show that the proposed CHAID-RS-BBO model yielded the highest predictive performance, with an overall accuracy of 90% in predicting flash floods, and outperformed benchmarks (i.e., the CHAID, the J48-DT, the logistic regression, and the multilayer perception neural network (MLP-NN) models). We conclude that the proposed method can accurately estimate the spatial prediction of flash floods in tropical storm areas

Investigating the Anti-Inflammatory Activity of Curcumin-Loaded Silica-Containing Redox Nanoparticles

Chronic inflammation is considered as one of the challenging diseases, and overproduction of reactive oxygen species (ROS) is strongly related to the onset of chronic inflammation. Therefore, antioxidant and anti-inflammatory approaches are particularly becoming suitable treatment and prevention of inflammation. Curcumin (CUR), a main component of turmeric extract, is well known as an effective agent in both antioxidant and anti-inflammatory activities; however, there are still some limitations of its use including poor water solubility, low bioavailability, and oxidation by ROS. Nanotechnology has been used as a drug delivery system, which is a promising approach in overcoming the aforementioned drawbacks of CUR; hence, it improves the antioxidant and anti-inflammatory effects of conventional medications. In this research, silica-containing redox nanoparticles (siRNP) were designed with the size of several tens of nanometers, prepared by self-assembly of an amphiphilic block copolymer consisting of drug absorptive silica moiety and ROS-scavenging nitroxide radical moiety in the hydrophobic segment. CUR was simply encapsulated into siRNP through the dialysis method, creating CUR-loaded siRNP (CUR@siRNP), which significantly improved the water solubility of CUR. The efficient antioxidant activity and anti-inflammatory effect of CUR@siRNP in vitro were also improved via 2,2-diphenyl-1-picrylhydrazyl assay and lipopolysaccharide-induced macrophage cell line activation, respectively. Oral administration of CUR@siRNP showed improvement in pharmacokinetic profile in vivo including AUC and Cmax values as compared to free CUR. Furthermore, the anti-inflammatory effect of nanoformulation was investigated in the colitis mouse model induced by dextran sodium sulfate

Understanding the Importance of Eco-Labeling for Organic Foods at UNESCO Biosphere Reserves: A Case Study of the Cocoa Powder at the Dong Nai, Vietnam

This study examined the willingness-to-pay (WTP) of consumers and the determinants of eco-labeling for the organic cocoa powder produced in the Dong Nai UNESCO Biosphere Reserve (DNBR), Southern Vietnam. Eco-labels are designed according to the tiers of eco-labeling for biosphere reserves (BR) introduced by UNESCO; they include BR Destination (Tier 1), BR Quality (Tier 2), and Professional Certification (Tier 3) labels. Questionnaires were delivered to 203 customers in the DNBR and nearby places, such as Dong Nai and HCMC. This study employed a hybrid approach using descriptive statistics, an ANOVA test, and a Partial Least Squares Structural Equation Model (PLS-SEM). The results indicate that gender and educational level have a positive effect on consumers’ preferences. Customers are willing to pay more for cocoa powder with an eco-label than one with an organic label. Perceived food safety and product knowledge lower customers’ WTP, whereas agricultural environment and pricing concerns increase it. Tier 2 is suggested for labeling cocoa powder in the DNBR. The DNBR Management Board, together with the federal and provincial governments, should all follow a similar certification process. Increased eco-label awareness is crucial for the future of environmentally responsible shopping and responsible business practices