19 research outputs found
La maladie de Weber-Christian: s'agit-il d'un état pré-leucémique?
La maladie de Weber-Christian ou panniculite idiopathique est une affection rare, caractĂ©risĂ©e par une inflammation du tissu adipeux sous-cutanĂ©; il s'agit d'une entitĂ© pathologique non spĂ©cifique qui reste toujours un sujet de dĂ©bat et dont l'Ă©volution est imprĂ©visible. Nous rapportons dans cet article le cas d'un nourrisson de sexe fĂ©minin de 9 mois, admise dans un tableau de sepsis prĂ©cĂ©dĂ© d'une symptomatologie respiratoire et suivi de l'apparition de nodositĂ©s sous cutanĂ©es Ă©rythĂ©mateuses, de petite taille, dures, sensibles, asymĂ©triques et situĂ©es au niveau des bras et des membres infĂ©rieurs, la biopsie cutanĂ©e a montrĂ© une hypodermite lobulaire avec infiltration des polynuclĂ©aires neutrophiles. La maladie de Weber-Christian a Ă©tĂ© retenue aprĂšs avoir Ă©liminĂ© les autres diagnostics diffĂ©rentiels. Notre patiente a Ă©tĂ© traitĂ©e par la prednisone avec une bonne Ă©volution initiale. Durant le suivi et au cours de la dĂ©gression, le diagnostic d'une leucĂ©mie aigue lymphoblastique type B a Ă©tĂ© posĂ©. Cette Ă©volution atypique Ă notre connaissance n'a jamais Ă©tĂ© dĂ©crite dans la littĂ©rature. Nous allons discuter Ă travers ce cas les diffĂ©rentes situations similaires oĂč un autre diagnostic a Ă©tĂ© fait aprĂšs avoir pris en charge les malades comme ayant une panniculite lobulaire idiopathique, en concluant de la nĂ©cessitĂ© d'une enquĂȘte Ă©tiologique exhaustive et d'une surveillance prolongĂ©e afin de rechercher une Ă©ventuelle pathologie associĂ©e
Consommation des produits lactĂ©s chez lâenfant et lâadolescent marocain de 2 Ă 16 ans: une Ă©tude monocentrique
Introduction: Evaluer la consommation quotidienne des produits laitiers dans une population dâenfants marocains et dĂ©terminer les facteurs associĂ©s pouvant influencer cette consommation. MĂ©thodes: Etude prospective du 1er octobre 2013 au 31 avril 2014. Les enfants ĂągĂ©s entre 2 et 16 ans ont Ă©tĂ© inclus. Le recrutement a eu lieu dans la ville de FĂšs. Le recueil des donnĂ©es sâest fait Ă lâaide dâun questionnaire frĂ©quentiel. Les parents et les enfants inclus ont Ă©tĂ© interrogĂ©s sur la consommation des produits laitiers et les facteurs socio-dĂ©mographiques avec une Ă©valuation anthropomĂ©trique des enfants. Lâassociation des variables Ă la consommation des produits aitiers a Ă©tĂ© analysĂ©e en analyse univariĂ©e et multivariĂ©e par un modĂšle de rĂ©gression logistique. RĂ©sultats: LâenquĂȘte alimentaire avait intĂ©ressĂ© 286 enfants dont 151 filles (52,8 %) et 131 garçons (45,8%). Les enfants ĂągĂ©s de 2 Ă 3 ans reprĂ©sentaient 26,4 %, ceux ĂągĂ©s de 4 Ă 7 ans 28,9 %, ceux ĂągĂ©s de 7 Ă 9 ans 18,3 % et les adolescents ĂągĂ©s de 10 Ă 16 ans 26,4 %. Les enfants consommaient en moyenne 2.5±1 produits laitiers par jour. Les enfants consommaient au moins 3 produits laitiers par jour dans 57,8% chez les enfants ĂągĂ©s de 2 Ă 3 ans, 53,6% chez les enfants ĂągĂ©s de 4 Ă 6 ans, 40% chez les enfants ĂągĂ©s de 7 Ă 9 ans et 41.2% chez les enfants ĂągĂ©s de 10 Ă 16 ans. Les facteurs associĂ©s Ă la consommation de trois produits laitiers minimum par jour en analyse univariĂ©e Ă©taient le niveau dâinstruction maternel analphabĂšte p < 0.001 OR = 0.1 et primaire p = 0.002 OR = 0.1, le niveau socioĂ©conomique familial moyen p < 0.001 OR = 3, lâĂąge p= 0.01 OR = 0.9 et lâindice de masse corporelle normal p = 0.01 OR = 2.5 et > 90° percentiles p < 0.001 OR = 6. Il existe un lien positif entre lâindice de masse corporelle > 90° percentiles p = 0.01 OR = 3.9 est et la quantitĂ© consommĂ©e des produits laitiers et nĂ©gatif avec le faible niveau de scolaritĂ© maternel analphabĂšte p = 0.008 OR = 0.1 et primaire p = 0.009 OR = 0.1. Conclusion: La consommation du lait et des autres produits laitiers Ă©tait inappropriĂ©e en particulier chez lâenfant ĂągĂ© de 7 Ă 9 ans et lâadolescent de 10 Ă 16 ans. Le faible niveau dâĂ©ducation maternel et un indice de masse corporelle supĂ©rieur au 90° percentiles Ă©tait des facteurs indĂ©pendamment associĂ©s Ă la consommation de moins de 3 produits laitiers par jour. La sensibilisation des parents et des enfants sur lâintĂ©rĂȘt du lait et de ses dĂ©rivĂ©s dans lâalimentation de lâenfant est indispensable
Child health and survival in the eastern mediterranean region
Most child deaths in the region are preventable and occur in just a few of the 22 countries in the region. The interventions are not expensive, but governments need to implement the
Metabolic profil in a group of obese Moroccan children enrolled in schools in the city of Rabat
Introduction: to determine the metabolic profile in a group of obese children in Morocco.
Methods: the BMI, the waist circumference, the blood pressure and metabolic parameters in 73 children (37 obese and 36 normal) were compared.
Results: 80% of obese children had abdominal obesity (p <0.0001). For systolic blood pressure among children who have a higher value than the 95th percentile, 85.7% were obese and 14.3% children are normal children. For diastolic blood pressure, 83.34% of obese children had higher diastolic blood pressure values in the 95th percentile and 16.6% of normal children have a higher value than the 95th percentile (p = 0.013). No obese child had hyperglycemia. The prevalence of metabolic syndrome was 21.6%.
Conclusion: obesity is number one risk of cardiovascular disease for children. Early detection can help for an appropriate care
Metabolic profil in a group of obese Moroccan children enrolled in schools in the city of Rabat
Abstract Introduction: to determine the metabolic profile in a group of obese children in Morocco. Methods: the BMI, the waist circumference, the bloo
Etiology, epidemiology and clinical characteristics of acute moderate-to-severe diarrhea in children under 5 years of age hospitalized in a referral pediatric hospital in Rabat, Morocco
The objective of the study was to describe the etiology, epidemiology, and clinical characteristics of the principal causes of acute infectious diarrhea requiring hospitalization among children under 5 years of age in Rabat, Morocco. A prospective study was conducted from March 2011 to March 2012, designed to describe the main pathogens causing diarrhea in hospitalized children >2 months and less than 5 years of age. Among the 122 children included in the study, Enteroaggregative E. coli (EAEC) and rotavirus were the main etiologic causes of diarrhea detected. Twelve (9.8%) children were referred to the intensive care unit, while 2, presenting infection by EAEC and EAEC plus a Shigella sonnei respectively, developed a hemolytic uremic syndrome. Additionally, 6 (4.9%) deaths occurred with EAEC being isolated in four of these cases. Diarrheogenic E. coli and rotavirus play a significant role as the two main causes of severe diarrhea while other pathogens such as norovirus or parasites seem to have a minimal contribution. Surveillance and prevention programs to facilitate early recognition and improved management of potentially life-threatening diarrhea-episodes are needed
Harmful Use of Veterinary Drugs: Blindness Following Closantel Poisoning in a 5-Year-Old Girl
Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning.
Case report: A 5-year-old girl was presented with acute blindness following closantel poisoning. She was given mistakenly a dose of 500 mg/day (25mg/kg/day) for 8 days. Clinical examination revealed a well-appearing child with bilateral mydriasis, loss of pupillary light reflex and absence of blinking to threat. Fundoscopic exam revealed bilateral pre-atrophic papilledema. Electroretinogram showed a highly significant decrease in retinal activity. Laboratory examinations revealed 52% increase in prothrombin time, prolongation of activated partial thromboplastin time to 1.3 times the normal and rise of aspartate aminotransferase to 120 IU/L. In addition, creatine kinase peaked at 904 IU/L. Moreover, normocytic normochromic anemia with hemoglobin at 10.7 mg/L and leukocytosis with lymphocytic predominance was noted. The patient received glucocorticoids, vitamin B12 and vitamin K and was discharged after correction of blood and coagulation parameters and normalization of liver enzymes. Partial recovery in visual acuity was found two months after ingestion of the last dose.
Discussion:Closantel can cause significant spongiform change (intra-myelin vacuolation) in the white matter of the cerebrum and the cerebellum. It can also induce optic nerve damage as a result of Wallerian degeneration, fibrosis and atrophy. On the retina, closantel leads to papilledema, necrosis of the outer layers, and retinal detachment. It can also cause fatty change and hydropic degeneration in the liver and hepatocellular degeneration.
Conclusion: Closantel is a toxic drug for humans causing blindness, hematologic and hepatic disorders. Public awareness should be raised regarding the risks of use of unapproved drugs for human