8,102 research outputs found
An examination of factors influencing the choice of therapy for patients with coronary artery disease
Background A diverse range of factors influence clinicians' decisions regarding the allocation of patients to different treatments for coronary artery disease in routine cardiology clinics. These include demographic measures, risk factors, co-morbidities, measures of objective cardiac disease, symptom reports and functional limitations. This study examined which of these factors differentiated patients receiving angioplasty from medication; bypass surgery from medication; and bypass surgery from angioplasty. Methods Univariate and multivariate logistic regression analyses were conducted on patient data from 214 coronary artery disease patients who at the time of recruitment had been received a clinical assessment and were reviewed by their cardiologist in order to determine the form of treatment they were to undergo: 70 would receive/continue medication, 71 were to undergo angioplasty and 73 were to undergo bypass surgery. Results Analyses differentiating patients receiving angioplasty from medication produced 9 significant univariate predictors, of which 5 were also multivariately significant (left anterior descending artery disease, previous coronary interventions, age, hypertension and frequency of angina). The analyses differentiating patients receiving surgery from angioplasty produced 12 significant univariate predictors, of which 4 were multivariately significant (limitations in mobility range, circumflex artery disease, previous coronary interventions and educational level). The analyses differentiating patients receiving surgery from medication produced 14 significant univariate predictors, of which 4 were multivariately significant (left anterior descending artery disease, previous cerebral events, limitations in mobility range and circumflex artery disease). Conclusion Variables emphasised in clinical guidelines are clearly involved in coronary artery disease treatment decisions. However, variables beyond these may also be important factors when therapy decisions are undertaken thus their roles require further investigation
Flight of the dragonflies and damselflies
This work is a synthesis of our current understanding of the mechanics, aerodynamics and visually mediated control of dragonfly and damselfly flight, with the addition of new experimental and computational data in several key areas. These are: the diversity of dragonfly wing morphologies, the aerodynamics of gliding flight, force generation in flapping flight, aerodynamic efficiency, comparative flight performance and pursuit strategies during predatory and territorial flights. New data are set in context by brief reviews covering anatomy at several scales, insect aerodynamics, neuromechanics and behaviour. We achieve a new perspective by means of a diverse range of techniques, including laser-line mapping of wing topographies, computational fluid dynamics simulations of finely detailed wing geometries, quantitative imaging using particle image velocimetry of on-wing and wake flow patterns, classical aerodynamic theory, photography in the field, infrared motion capture and multi-camera optical tracking of free flight trajectories in laboratory environments. Our comprehensive approach enables a novel synthesis of datasets and subfields that integrates many aspects of flight from the neurobiology of the compound eye, through the aeromechanical interface with the surrounding fluid, to flight performance under cruising and higher-energy behavioural modes
A statistical network analysis of the HIV/AIDS epidemics in Cuba
The Cuban contact-tracing detection system set up in 1986 allowed the
reconstruction and analysis of the sexual network underlying the epidemic
(5,389 vertices and 4,073 edges, giant component of 2,386 nodes and 3,168
edges), shedding light onto the spread of HIV and the role of contact-tracing.
Clustering based on modularity optimization provides a better visualization and
understanding of the network, in combination with the study of covariates. The
graph has a globally low but heterogeneous density, with clusters of high
intraconnectivity but low interconnectivity. Though descriptive, our results
pave the way for incorporating structure when studying stochastic SIR epidemics
spreading on social networks
Assortative Mixing Equilibria in Social Network Games
It is known that individuals in social networks tend to exhibit homophily
(a.k.a. assortative mixing) in their social ties, which implies that they
prefer bonding with others of their own kind. But what are the reasons for this
phenomenon? Is it that such relations are more convenient and easier to
maintain? Or are there also some more tangible benefits to be gained from this
collective behaviour?
The current work takes a game-theoretic perspective on this phenomenon, and
studies the conditions under which different assortative mixing strategies lead
to equilibrium in an evolving social network. We focus on a biased preferential
attachment model where the strategy of each group (e.g., political or social
minority) determines the level of bias of its members toward other group
members and non-members. Our first result is that if the utility function that
the group attempts to maximize is the degree centrality of the group,
interpreted as the sum of degrees of the group members in the network, then the
only strategy achieving Nash equilibrium is a perfect homophily, which implies
that cooperation with other groups is harmful to this utility function. A
second, and perhaps more surprising, result is that if a reward for inter-group
cooperation is added to the utility function (e.g., externally enforced by an
authority as a regulation), then there are only two possible equilibria,
namely, perfect homophily or perfect heterophily, and it is possible to
characterize their feasibility spaces. Interestingly, these results hold
regardless of the minority-majority ratio in the population.
We believe that these results, as well as the game-theoretic perspective
presented herein, may contribute to a better understanding of the forces that
shape the groups and communities of our society
Correlation between clustering and degree in affiliation networks
We are interested in the probability that two randomly selected neighbors of
a random vertex of degree (at least) are adjacent. We evaluate this
probability for a power law random intersection graph, where each vertex is
prescribed a collection of attributes and two vertices are adjacent whenever
they share a common attribute. We show that the probability obeys the scaling
as . Our results are mathematically rigorous. The
parameter is determined by the tail indices of power law
random weights defining the links between vertices and attributes
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A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia.
Inhibition of farnesyltransferase (FT) activity has been associated with in vitro and in vivo anti-leukemia activity. We report the results of a phase 1 dose-escalation study of tipifarnib, an oral FT inhibitor, in patients with relapsed, refractory or newly diagnosed (if over age 70) acute myelogenous leukemia (AML), on a week-on, week-off schedule. Forty-four patients were enrolled, two patients were newly diagnosed, and the rest were relapsed or refractory to previous treatment, with a median age of 61 (range 33-79). The maximum tolerated dose was determined to be 1200 mg given orally twice daily (b.i.d.) on this schedule. Cycle 1 dose-limiting toxicities were hepatic and renal. There were three complete remissions seen, two at the 1200 mg b.i.d. dose and one at the 1000 mg b.i.d. dose, with minor responses seen at the 1400 mg b.i.d. dose level. Pharmacokinetic studies performed at doses of 1400 mg b.i.d. showed linear behavior with minimal accumulation between days 1-5. Tipifarnib administered on a week-on, week-off schedule shows activity at higher doses, and represents an option for future clinical trials in AML
The Naming Game in Social Networks: Community Formation and Consensus Engineering
We study the dynamics of the Naming Game [Baronchelli et al., (2006) J. Stat.
Mech.: Theory Exp. P06014] in empirical social networks. This stylized
agent-based model captures essential features of agreement dynamics in a
network of autonomous agents, corresponding to the development of shared
classification schemes in a network of artificial agents or opinion spreading
and social dynamics in social networks. Our study focuses on the impact that
communities in the underlying social graphs have on the outcome of the
agreement process. We find that networks with strong community structure hinder
the system from reaching global agreement; the evolution of the Naming Game in
these networks maintains clusters of coexisting opinions indefinitely. Further,
we investigate agent-based network strategies to facilitate convergence to
global consensus.Comment: The original publication is available at
http://www.springerlink.com/content/70370l311m1u0ng3
Uncovering the overlapping community structure of complex networks in nature and society
Many complex systems in nature and society can be described in terms of
networks capturing the intricate web of connections among the units they are
made of. A key question is how to interpret the global organization of such
networks as the coexistence of their structural subunits (communities)
associated with more highly interconnected parts. Identifying these a priori
unknown building blocks (such as functionally related proteins, industrial
sectors and groups of people) is crucial to the understanding of the structural
and functional properties of networks. The existing deterministic methods used
for large networks find separated communities, whereas most of the actual
networks are made of highly overlapping cohesive groups of nodes. Here we
introduce an approach to analysing the main statistical features of the
interwoven sets of overlapping communities that makes a step towards uncovering
the modular structure of complex systems. After defining a set of new
characteristic quantities for the statistics of communities, we apply an
efficient technique for exploring overlapping communities on a large scale. We
find that overlaps are significant, and the distributions we introduce reveal
universal features of networks. Our studies of collaboration, word-association
and protein interaction graphs show that the web of communities has non-trivial
correlations and specific scaling properties.Comment: The free academic research software, CFinder, used for the
publication is available at the website of the publication:
http://angel.elte.hu/clusterin
The role of asymmetric interactions on the effect of habitat destruction in mutualistic networks
Plant-pollinator mutualistic networks are asymmetric in their interactions:
specialist plants are pollinated by generalist animals, while generalist plants
are pollinated by a broad involving specialists and generalists. It has been
suggested that this asymmetric ---or disassortative--- assemblage could play an
important role in determining the equal susceptibility of specialist and
generalist plants under habitat destruction. At the core of the argument lies
the observation that specialist plants, otherwise candidates to extinction,
could cope with the disruption thanks to their interaction with generalist
pollinators. We present a theoretical framework that supports this thesis. We
analyze a dynamical model of a system of mutualistic plants and pollinators,
subject to the destruction of their habitat. We analyze and compare two
families of interaction topologies, ranging from highly assortative to highly
disassortative ones, as well as real pollination networks. We found that
several features observed in natural systems are predicted by the mathematical
model. First, there is a tendency to increase the asymmetry of the network as a
result of the extinctions. Second, an entropy measure of the differential
susceptibility to extinction of specialist and generalist species show that
they tend to balance when the network is disassortative. Finally, the
disappearance of links in the network, as a result of extinctions, shows that
specialist plants preserve more connections than the corresponding plants in an
assortative system, enabling them to resist the disruption.Comment: 14 pages, 7 figure
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