Towards the total synthesis of 14-acetoxygelsenicine and synthesis of largazole analogs

2009 Summer.Includes bibliographical references.Herein are documented our efforts in two projects, beginning with studies towards the total synthesis of 14-acetoxygelsenicine. We have developed different strategies towards this complex natural product, wherein we have developed routes towards an appropriate substrate for a novel, intramolecular hetero Diels-Alder cyclization. The developed route would also lead to related members of this family of alkaloids, and helps set the stage for future efforts. In the second project discussed, we have successfully pursued the synthesis of numerous, biologically active analogs of the natural product (+)-largazole. Synthetic efforts have led to the design of inhibitors with unprecedented biological activity, as well as providing information regarding the structure-activity relationship of these molecules

Pendulum-type nutation damper used in the nasa atmospheric structure satellite, s-6

Passive device for damping nutational motion of spin stabilized Explorer XVII satellit

An analytical approach to solution of two- point boundary condition problems in optimal guidance Summary report, May 1965 - Apr. 1966

Analytical approaches to path-adaptive guidance functions, circular orbit trajectories, and use of Fortran-compiled program

New technique for measuring photonuclear cross sections and its applications to the CU-63(y,n)CU-62 and C-12(y,n)C-11 reactions

A new technique for the determination of photonuclear cross sections is described in detail. It was applied to the CU-63(y,n)CU-62 and C-12(y,n)C-11 reactions from thresholds up to 60 Mev. The results obtained are consistent and are in good agreement with results obtained by different methods (1,2)

Cerebral dehydration action of glycerol; I. Historical aspects with emphasis on the toxicity and intravenous administration

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117051/1/cpt1972132159.pd

Competitive Advantage from the World Wide Web

Research has suggested that organizations implement World Wide Web sites in order to gain competitive advantage. This research-in-progress uses CAPITA, an instrument for measuring competitive advantage, to determine how organizations seek to use the Web for competitive advantage and how well they succeed