Inspiring the generations: the Knitting Reference Library

The Knitting Reference Library (KRL) is part of the University of Southampton Library, and is located at Winchester School of Art, a campus of the University. The KRL was launched at the first In the loop conference in 2008 and is founded on the bibliographic collections of Richard Rutt, Montse Stanley and Jane Waller. Each collector possessed a serious passion for knitting, their individual approaches are illustrated through the resources they collected and established as an essential part oftheir working lives.The library comprises nearly 2000 books, 425 journal and magazine titles, an estimated 12,000 knitting patterns and hundreds of knitting pattern books. It includes many widely known classic books from the Victorian period through the decades of the twentieth century to the present day

At BABE with the knitting and sewing school

An article written by Linda Newington on the subject of knitting

Town of Newington Stormwater Management Project

The UNH Stormwater Center worked with the Newington Planning Board to improve the town’s site plan review regulations to better manage stormwater

Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer\u27s disease

Alzheimer’s disease (AD) is characterized by deposition of the amyloid beta (Ab) peptide in the brain, an event which frequently but not universally correlates with nerve cell death. Although most nerve cells die in response to Ab, small populations of cells are able to survive by becoming resistant to Ab toxicity. Understanding the mechanisms by which cells become resistant to Ab may reveal novel treatments for AD. Interestingly, nerve cell lines selected for resistance against Ab exhibit increased glucose uptake and glycolytic flux. Here I show that these metabolic changes are mediated through an upregulation of pyruvate dehydrogenase kinase 1 (PDK1) and increased lactate dehydrogenase A (LDHA) activity. These metabolic alterations in Ab resistant nerve cells are reminiscent of the Warburg effect, also known as aerobic glycolysis, a common anti-apoptotic mechanism elicited by cancer cells. Similar to cancer cells, Ab-resistant nerve cells exhibit reduced mitochondrial reactive oxygen species (ROS) production. Inhibiting PDK1 or LDHA expression or activity re-sensitized resistant cells to Ab toxicity. In contrast, overexpression of either PDK1 or LDHA in sensitive cells conferred resistance to Ab and other neurotoxins. Importantly, cells overexpressing either PDK1 or LDHA displayed repressed mitochondrial oxygen consumption with a concomitant decrease in mitochondrial ROS levels. Furthermore, these cells maintained cellular adenosine triphosphate (ATP) pools when exposed to Ab, whereas sensitive cells became depleted of ATP. Immunoblot analysis revealed a decrease in PDK1 and LDHA levels in mouse primary cortical neurons treated with Aβ and in cortical tissue extracts from 12-month-old AD transgenic (APPswe/PS1dE9) mice. A similar decrease in PDK1 expression was observed in post-mortem brain extracts from AD patients. Treatment of cultured nerve cell lines and primary cortical neurons with CNB-001 and J147, novel neurotrophic drugs that prevent cognitive decline in AD mice, restored PDK1 and LDHA expression following Ab treatment. Moreover, PDK1 expression was maintained in AD mice fed CNB-001. Collectively, these findings suggest that the Warburg effect plays a central role in mediating neuronal resistance to Αβ by decreasing mitochondrial activity and subsequent ROS production. Loss of this protective effect may render elderly individuals susceptible to AD

Town of Newington, New Hampshire annual report 2018.

This is an annual report containing vital statistics for a town/city in the state of New Hampshire

Town of Newington, New Hampshire annual report for year ending December 31, 2005 including the annual report of the Newington school district for fiscal year July 1, 2004 to June 30, 2005.

This is an annual report containing vital statistics for a town/city in the state of New Hampshire

Annual reports of the selectmen, treasurer, highway agents, auditors, board of education, library trustees, trustees of town trust funds and town clerk of the town of Newington, N.H. for the year ending January 31, 1935.

This is an annual report containing vital statistics for a town/city in the state of New Hampshire

Annual reports of the selectmen, treasurer, highway agent, auditors, board of education, library trustees, trustees of town trust funds and town clerk of the town of Newington, New Hampshire for the year ending December 31, 1954.

This is an annual report containing vital statistics for a town/city in the state of New Hampshire

Annual reports of the town of Newington, New Hampshire for the year ending December 31, 1973.

This is an annual report containing vital statistics for a town/city in the state of New Hampshire