The Implementation of Engineering Design Challenges on 4th Grade Students\u27 Attitudes Towards Engineering, Classroom Climate, and Writing Ability

The purpose of this study was to determine if my practice of having 4th grade students participate in engineering design challenges impacted their attitudes towards engineering, the classroom climate, and writing ability. In this action research students were given a pre and posttest that measured their attitudes towards engineering and their perceptions of the classroom climate. A pre and post written reflection was also examined and compared for the use of predicting, observing, thinking, explaining, reflecting, and yearning to learn more. A triangulation of data included the use of pre and posttest statistical analysis, rubrics, teacher observation, and student interviews. The data collected from this action research project showed that that students were more satisfied with the course after completing the design challenges, the classroom environment improved in that students perceived the level of friction in the class had decreased. The data collected also showed that students\u27 attitudes towards engineers was changed in that they were more likely to want to pursue a career in engineering and take a future school course in engineering after having completed this action research. Student generated definitions of engineers demonstrated a decrease in the number of misconceptions about the work of engineers and an increase in students\u27 knowledge as to what engineers do for a living. My practice of implementing engineering design challenges with a 4th grade class did not have an impact on students writing ability

Constraining the initial temperature and shear viscosity in a hybrid hydrodynamic model of sNN\sqrt{s_{NN}}=200 GeV Au+Au collisions using pion spectra, elliptic flow, and femtoscopic radii

A new framework for evaluating hydrodynamic models of relativistic heavy ion collisions has been developed. This framework, a Comprehesive Heavy Ion Model Evaluation and Reporting Algorithm (CHIMERA) has been implemented by augmenting UVH 2+1D viscous hydrodynamic model with eccentricity fluctuations, pre-equilibrium flow, and the Ultra-relativistic Quantum Molecular Dynamic (UrQMD) hadronic cascade. A range of initial temperatures and shear viscosity to entropy ratios were evaluated for four initial profiles, $N_{part}$ and $N_{coll}$ scaling with and without pre-equilibrium flow. The model results were compared to pion spectra, elliptic flow, and femtoscopic radii from 200 GeV Au+Au collisions for the 0--20% centrality range.Two sets of initial density profiles, $N_{part}$ scaling with pre-equilibrium flow and $N_{coll}$ scaling without were shown to provide a consistent description of all three measurements.Comment: 21 pages, 32 figures, version 3 includes additional text for clarification, division of figures into more manageable units, and placement of chi-squared values in tables for ease of viewin

Extended-release ranolazine: critical evaluation of its use in stable angina

Coronary heart disease is the major cause of morbidity and mortality throughout the world, and is responsible for approximately one of every six deaths in the US. Angina pectoris is a clinical syndrome characterized by discomfort, typically in the chest, neck, chin, or left arm, induced by physical exertion, emotional stress, or cold, and relieved by rest or nitroglycerin. The main goals of treatment of stable angina pectoris are to improve quality of life by reducing the severity and/or frequency of symptoms, to increase functional capacity, and to improve prognosis. Ranolazine is a recently developed antianginal with unique methods of action. In this paper, we review the pharmacology of ranolazine, clinical trials supporting its approval for clinical use, and studies of its quality of life benefits. We conclude that ranolazine has been shown to be a reasonable and safe option for patients who have refractory ischemic symptoms despite the use of standard medications (for example, nitrates, beta-adrenergic receptor antagonists, and calcium channel antagonists) for treatment of anginal symptoms, and also provides a modestly improved quality of life

The Newly developed competitiveness orientation measure : psychometric development and evaluation

The concept of competitiveness as a personality trait has been alluded to for over 70 years; yet, it has surprisingly been largely neglected as an individual differences variable. Instead, researchers have focused on the application of competitiveness to more context-specific environments, such as sports, academics and occupational settings. In spite of the potential utility of identifying individual differences in competitiveness, there currently exists no psychometrically valid, broadly applicable and unified measure of these differences. Furthermore, a review of the literature, has illuminated the need for at least two underlying dimensions of this trait; Dominant and Personal-Enhancement competitiveness. Thus, the goal of the present study is to provide preliminary construct-validity and confirmation of the factor structure of a new measure of competitiveness: the Competitiveness Orientation Measure. The initial 137-item Competitiveness Orientation Measure was tested in two independent samples of 886 University, and community participants. Examination of item-total correlations, discrimination indices and factor analysis procedures using Horn's Parallel Analysis and the Velicer's test resulted in the retention of 37 final items with Cronbach's alpha reported as .96 and split-half reliability reported as .93. Retained items supported past theoretical accounts of Dominant and Personal-Enhancement competitiveness in addition to two newly-emerged dimensions corresponding to General Competitiveness and Pervasive Competitiveness. Theoretically, the Competitiveness Orientation Measure is the first comprehensive, psychometrically valid scale that adequately captures individual differences in competitiveness across four dimensions. Multidimensional differences in competitiveness may serve to differentiate competitors' success in sports, occupational and academic contexts

cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1

AbstractElevation of intracellular cAMP concentration has numerous vascular protective effects that are in part mediated via actin cytoskeleton-remodelling and subsequent regulation of gene expression. However, the mechanisms are incompletely understood. Here we investigated whether cAMP-induced actin-cytoskeleton remodelling modulates VSMC behaviour by inhibiting expression of CCN1. In cultured rat VSMC, CCN1-silencing significantly inhibited BrdU incorporation and migration in a wound healing assay. Recombinant CCN1 enhanced chemotaxis in a Boyden chamber. Adding db-cAMP, or elevating cAMP using forskolin, significantly inhibited CCN1 mRNA and protein expression in vitro; transcriptional regulation was demonstrated by measuring pre-spliced CCN1 mRNA and CCN1-promoter activity. Forskolin also inhibited CCN1 expression in balloon injured rat carotid arteries in vivo. Inhibiting RhoA activity, which regulates actin-polymerisation, by cAMP-elevation or pharmacologically with C3-transferase, or inhibiting its downstream kinase, ROCK, with Y27632, significantly inhibited CCN1 expression. Conversely, expression of constitutively active RhoA reversed the inhibitory effects of forskolin on CCN1 mRNA. Furthermore, CCN1 mRNA levels were significantly decreased by inhibiting actin-polymerisation with latrunculin B or increased by stimulating actin-polymerisation with Jasplakinolide. We next tested the role of the actin-dependent SRF co-factor, MKL1, in CCN1 expression. Forskolin inhibited nuclear translocation of MKL1 and binding of MKL1 to the CCN1 promoter. Constitutively-active MKL1 enhanced basal promoter activity of wild-type but not SRE-mutated CCN1; and prevented forskolin inhibition. Furthermore, pharmacological MKL-inhibition with CCG-1423 significantly inhibited CCN1 promoter activity as well as mRNA and protein expression. Our data demonstrates that cAMP-induced actin-cytoskeleton remodelling regulates expression of CCN1 through MKL1: it highlights a novel cAMP-dependent mechanism controlling VSMC behaviour

QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: A case report and review of the literature

Vorinostat is a histone deacetylase inhibitor used in the treatment of recurrent or persistent cases of cutaneous T-cell lymphoma (CTCL). A retrospective review of 116 patients from phase I and II clinical trials who had a baseline and at least one subsequent ECG revealed that four patients had Grade 2 and one patient had Grade 3 QTc interval prolongation; however, a MEDLINE search found no reported cases of torsades de pointes (TdP) in patients treated with vorinostat. We describe the case of a 49 year-old male with a history of CTCL actively undergoing treatment with vorinostat. During day 1 of hospitalization, he developed a pulseless polymorphic ventricular tachycardia requiring resuscitation. He was found to have a QTc of 826 ms. Following correction of potassium and magnesium, QTc gradually decreased and no further ventricular arrhythmia was noted. Other factors implicated in this case included concurrent sertraline and doxepin therapy (both drugs have been associated with the development of TdP in overdose). The mechanism of development of TdP in this patient is postulated to be related to vorinostat use in combination with hypokalemia and concomitant treatment with medications associated with QTc prolongation. This case highlights the importance of post-market surveillance