Colon Adenocarcinoma and Paraneoplastic Polymyositis: the Importance of a Rehabilitation Program

O carcinoma do cólon e recto é o tumor gastrointestinal mais frequente. A polimiosite é uma doença rara, inflamatória, frequentemente idiopática, que se manifesta por diminuição da força muscular proximal. Raramente, pode associar-se a síndrome paraneoplásica. Existem diversos estudos sobre a relação entre neoplasias e dermatomiosite ou polimiosite. Contudo, a associação do adenocarcinoma do cólon e miopatias inflamatórias é uma raridade, especialmente na ausência de lesões cutâneas. Apresentamos o caso clínico de uma doente com adenocarcinoma do cólon, avaliada no serviço de urgência por quadro de polimiosite paraneoplásica, e posterior seguimento clínico em enfermaria, salientando o papel da reabilitação na vertente do doente oncológico e nesta entidade clínica em particular.info:eu-repo/semantics/publishedVersio

Painful Hemiplegic Shoulder: From Prevention to Treatment

O ombro doloroso do hemiplégico pode surgir entre duas semanas e quatro meses após o acidente vascular cerebral. Apresenta elevada incidência e tem frequentemente etiologia multifatorial. O seu tratamento constitui um desafio na prática clínica, sendo por vezes a resposta terapêutica pobre, comprometendo os resultados do programa de reabilitação. A abordagem estruturada poderá ajudar a uma melhor resposta terapêutica e contribuir para o sucesso da reabilitação e qualidade de vida do doente. Este trabalho pretende sistematizar a abordagem terapêutica do ombro doloroso do hemiplégico de acordo com os níveis de evidência existentes.info:eu-repo/semantics/publishedVersio

Rubber Impact on 3D Textile Composites

A low velocity impact study of aircraft tire rubber on 3D textile-reinforced composite plates was performed experimentally and numerically. In contrast to regular unidirectional composite laminates, no delaminations occur in such a 3D textile composite. Yarn decohesions, matrix cracks and yarn ruptures have been identified as the major damage mechanisms under impact load. An increase in the number of 3D warp yarns is proposed to improve the impact damage resistance. The characteristic of a rubber impact is the high amount of elastic energy stored in the impactor during impact, which was more than 90% of the initial kinetic energy. This large geometrical deformation of the rubber during impact leads to a less localised loading of the target structure and poses great challenges for the numerical modelling. A hyperelastic Mooney-Rivlin constitutive law was used in Abaqus/Explicit based on a step-by-step validation with static rubber compression tests and low velocity impact tests on aluminium plates. Simulation models of the textile weave were developed on the meso- and macro-scale. The final correlation between impact simulation results on 3D textile-reinforced composite plates and impact test data was promising, highlighting the potential of such numerical simulation tools

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Chromatin structure is a major regulator of transcription and gene expression. Herein we explore the use of osmotic modulation to modify the chromatin structure and reprogram gene expression. In this study we use the extracellular osmotic pressure as a chromatin structure and transcriptional modulator. Hyposmotic modulation promotes chromatin loosening and induces changes in RNA polymerase II (Pol II) activity. The chromatin decondensation opens space for higher amounts of DNA engaged RNA Pol II. Hyposmotic modulation constitutes an alternative route to manipulate cell fate decisions. This technology was tested in model protocols of induced pluripotency and transdifferentiation in cells growing in suspension and adherent to substrates, CD34+ umbilical-cord-blood (UCB), fibroblasts and B-cells. The efficiency and kinetics of these cell fate modulation processes were improved by transient hyposmotic modulation of the cell environment

Author Correction: Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Correction to: Scientific Reports https://doi.org/10.1038/s41598-018-25517-2, published online 08 May 2018