MONTE CARLO SIMULATIONS OF MUON PRODUCTION

Muon production requirements for a muon collider are presented. Production of muons from pion decay is studied. Lithium lenses and solenoids are considered for focussing pions from a target, and for matching the pions into a decay channel. Pion decay channels of alternating quadrupoles and long solenoids are compared. Monte Carlo simulations are presented for production of $\pi \rightarrow \mu$ by protons over a wide energy range, and criteria for choosing the best proton energy are discussed.Comment: Latex uses mu95.sty, 19 pages, 5 postscript figures. A postscript file can be seen at URL http://www.cap.bnl.gov/~cap/mumu/important.html Search for Publication

A Complete Scheme of Ionization Cooling for a Muon Collider

A complete scheme for production and cooling a muon beam for three specified muon colliders is presented. Parameters for these muon colliders are given. The scheme starts with the front end of a proposed neutrino factory that yields bunch trains of both muon signs. Emittance exchange cooling in slow helical lattices reduces the longitudinal emittance until it becomes possible to merge the trains into single bunches, one of each sign. Further cooling in all dimensions is applied to the single bunches in further slow helical lattices. Final transverse cooling to the required parameters is achieved in 50 T solenoids using high Tc superconductor at 4 K. Preliminary simulations of each element are presented.Comment: 3 pages, 6 figure

A Cost-Effective Design for a Neutrino Factory

There have been active efforts in the U.S., Europe, and Japan on the design of a Neutrino Factory. This type of facility produces intense beams of neutrinos from the decay of muons in a high energy storage ring. In the U.S., a second detailed Feasibility Study (FS2) for a Neutrino Factory was completed in 2001. Since that report was published, new ideas in bunching, cooling and acceleration of muon beams have been developed. We have incorporated these ideas into a new facility design, which we designate as Study 2B (ST2B), that should lead to significant cost savings over the FS2 design.Comment: 46 pages, 38 figures; to be submitted to Physical Review Special Topics: Accelerators and Beam

Ab Initio Liquid Hydrogen Muon Cooling Simulations with ELMS in ICOOL

This paper presents new theoretical results on the passage of muons through liquid hydrogen which have been confirmed in a recent experiment. These are used to demonstrate that muon bunches may be compressed by ionisation cooling more effectively than suggested by previous calculations. Muon cooling depends on the differential cross section for energy loss and scattering of muons. We have calculated this cross section for liquid H2 from first principles and atomic data, avoiding traditional assumptions. Thence, 2-D probability maps of energy loss and scattering in mm-scale thicknesses are derived by folding, and stored in a database. Large first-order correlations between energy loss and scattering are found for H2, which are absent in other simulations. This code is named ELMS, Energy Loss & Multiple Scattering. Single particle trajectories may then be tracked by Monte Carlo sampling from this database on a scale of 1 mm or less. This processor has been inserted into the cooling code ICOOL. Significant improvements in 6-D muon cooling are predicted compared with previous predictions based on GEANT. This is examined in various geometries. The large correlation effect is found to have only a small effect on cooling. The experimental scattering observed for liquid H2 in the MUSCAT experiment has recently been reported to be in good agreement with the ELMS prediction, but in poor agreement with GEANT simulation.Comment: 6 pages, 3 figure

Inhibition of Angiogenesis by Treatment with Cold Atmospheric Plasma as a Promising Therapeutic Approach in Oncology

Background: Cold atmospheric plasma (CAP) is increasingly used in the field of oncology. Many of the mechanisms of action of CAP, such as inhibiting proliferation, DNA breakage, or the destruction of cell membrane integrity, have been investigated in many different types of tumors. In this regard, data are available from both in vivo and in vitro studies. Not only the direct treatment of a tumor but also the influence on its blood supply play a decisive role in the success of the therapy and the patient’s further prognosis. Whether the CAP influences this process is unknown, and the first indications in this regard are addressed in this study. Methods: Two different devices, kINPen and MiniJet, were used as CAP sources. Human endothelial cell line HDMEC were treated directly and indirectly with CAP, and growth kinetics were performed. To indicate apoptotic processes, caspase-3/7 assay and TUNEL assay were used. The influence of CAP on cellular metabolism was examined using the MTT and glucose assay. After CAP exposure, tube formation assay was performed to examine the capillary tube formation abilities of HDMEC and their migration was messured in separate assays. To investigate in a possible mutagenic effect of CAP treatment, a hypoxanthine-guanine-phosphoribosyl-transferase assay with non malignant cell (CCL-93) line was performed. Results: The direct CAP treatment of the HDMEC showed a robust growth-inhibiting effect, but the indirect one did not. The MMT assay showed an apparent reduction in cell metabolism in the first 24 h after CAP treatment, which appeared to normalize 48 h and 72 h after CAP application. These results were also confirmed by the glucose assay. The caspase 3/7 assay and TUNEL assay showed a significant increase in apoptotic processes in the HDMEC after CAP treatment. These results were independent of the CAP device. Both the migration and tube formation of HDMEC were significant inhibited after CAP-treatment. No malignant effects could be demonstrated by the CAP treatment on a non-malignant cell line. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

The experimental program for high pressure gas filled radio frequency cavities for muon cooling channels

An intense beam of muons is needed to provide a luminosity on the order of 10(34) cm(-2)s(-1) for a multi-TeV collider. Because muons produced by colliding a multi-MW proton beam with a target made of carbon or mercury have a large phase space, significant six dimensional cooling is required. Through ionization cooling - the only cooling method that works within the lifetime of the muon - and emittance exchange, the desired emittances for a Higgs Factory or higher energy collider are attainable. A cooling channel utilizing gas filled radio frequency cavities has been designed to deliver the requisite cool muon beam. Technology development of these RF cavities has progressed from breakdown studies, through beam tests, to dielectric loaded and reentrant cavity designs. The results of these experiments are summarized