Neural synchrony in cortical networks : history, concept and current status

Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, the role of neural synchrony in cortical networks has been expanded to provide a general mechanism for the coordination of distributed neural activity patterns. In the current paper, we present an update of the status of this hypothesis through summarizing recent results from our laboratory that suggest important new insights regarding the mechanisms, function and relevance of this phenomenon. In the first part, we present recent results derived from animal experiments and mathematical simulations that provide novel explanations and mechanisms for zero and nero-zero phase lag synchronization. In the second part, we shall discuss the role of neural synchrony for expectancy during perceptual organization and its role in conscious experience. This will be followed by evidence that indicates that in addition to supporting conscious cognition, neural synchrony is abnormal in major brain disorders, such as schizophrenia and autism spectrum disorders. We conclude this paper with suggestions for further research as well as with critical issues that need to be addressed in future studies

Review on Experimental and Theoretical Investigations of Ultra-Short Pulsed Laser Ablation of Metals with Burst Pulses

Laser processing with ultra-short double pulses has gained attraction since the beginning of the 2000s. In the last decade, pulse bursts consisting of multiple pulses with a delay of several 10 ns and less found their way into the area of micromachining of metals, opening up completely new process regimes and allowing an increase in the structuring rates and surface quality of machined samples. Several physical effects such as shielding or re-deposition of material have led to a new understanding of the related machining strategies and processing regimes. Results of both experimental and numerical investigations are placed into context for different time scales during laser processing. This review is dedicated to the fundamental physical phenomena taking place during burst processing and their respective effects on machining results of metals in the ultra-short pulse regime for delays ranging from several 100 fs to several microseconds. Furthermore, technical applications based on these effects are reviewed

Delamination detection in a 90-year-old glulam block with scanning dry point-contact ultrasound

Glued laminated timber (glulam) is known in timber constructions since more than 100 years. Glulam members can delaminate due to aging and excessive changes of temperature and humidity. This results in significantly reduced load bearing capability of the affected structural members. This contribution focuses on the ultrasonic point-contact inspection of gluing plane delamination as a nondestructive method. Ultrasonic measurements on a section of a 90-year-old roofing glulam member are presented. The results are compared with manual detection and evaluation of delamination with a feeler gauge, with X-ray computed tomography analyses, and with numerical simulations. Appropriate data evaluation of the mechanized ultrasonic results allows the determination of material separation that are deeper than 20 mm in the signature of the surface wave and large-scale delamination (>80% of the complete bonding width) in the back-wall echo. Numerical simulations based on the finite-difference time-domain method shed light into the details of the wave propagation and support the experimental finding

Air-coupled ultrasound inspection of glued laminated timber

A novel air-coupled ultrasound (ACU) 120kHz normal transmission system enabled successful imaging of bonding and saw cut defects in multilayered glulam beams up to 280mm in height with a signal-to-noise ratio (SNR) of 40dB. The main wave propagation paths were modeled; quasi-longitudinal and quasi-transverse modes were coupled in each lamella and the sound field was found to be shifted from the insonification axis as a function of the ring angle, leading to interference of wave paths in the receiver and to 15dB amplitude variability in defect-free glulam. The assessment was improved with spatial processing algorithms that profited from the arbitrary scanning resolution and high reproducibility of ACU. Overlapped averaging reduced in-band noise by 15dB, amplitude tracking captured only the first incoming oscillation, thus minimizing diffraction around defect regions, and image normalization compensated 6dB of systematic amplitude variability across the fiber direction. The application of ACU to in situ defect monitoring was demonstrated by using multiparameter difference imaging of measurements of the same sample with and without saw cut defects. The segmentation of the defect geometry was improved significantly and the amplitude variability was reduced by 10dB. Further work is planned to model additional insonification setups and grain and density heterogeneitie

Polymorphisms in DMRT1 coding and promoter regions are probably not causative for swine sex reversal (XX, SRY-negative) syndrome

SRY-negative XX sex reversal is an inherited or sporadically occurring disorder, where testis development appears in the absence of the SRY gene. Although the molecular background of this intersexuality syndrome in pigs is unknown, it was proposed that familial cases might be inherited as a single autosomal recessive trait. Because DMRT1 (Doublesex and Mab-3 related transcription factor 1) is an autosomal locus in pig (SSC1q21), shows sexually dimorphic expression in swine gonads and has strong significance in vertebrate testis development, the molecular analysis of this gene was performed in previously reported three intersexes (38,XX, SRY-negative), the progeny of a single boar from a Polish farm. The first two exons encoding functional DM (double sex and mab-3) domain and the promoter region (the 5'flanking sequence) (altogether 3894 bp) were sequenced and compared with male and female control pigs (n = 16) and with publicly available sequences. Three different polymorphisms were found in the coding region, one Indel type polymorphism (DNA 142_144indelAGC) causing a deletion of an amino acid (protein S47_G48indelS) and two silent SNPs (DNA G432A and G492A). The promoter region seems to be highly polymorphic, since 17 SNPs and 5 indels were detected. However, the sequences of control males and females were concordant with those of the intersexes. These results indicate that DMRT1 is an unlikely candidate gene for SRY-negative XX sex reversal in pig

Noether symmetries for two-dimensional charged particle motion

We find the Noether point symmetries for non-relativistic two-dimensional charged particle motion. These symmetries are composed of a quasi-invariance transformation, a time-dependent rotation and a time-dependent spatial translation. The associated electromagnetic field satisfy a system of first-order linear partial differential equations. This system is solved exactly, yielding three classes of electromagnetic fields compatible with Noether point symmetries. The corresponding Noether invariants are derived and interpreted

Measuring Optical Properties On Rough And Liquid Metal Surfaces

For understanding and optimizing laser processing of metals and alloys the optical properties, especially the absorption of the work piece in function of the temperature up to the liquid phase have to be known [1]. There are several approaches to extend the Drude-Model [2] for optical properties of metal to temperature dependence [3, 4, 5]. However, a verification of these models is difficult due to the lack of sufficient experimental data. Even though measuring optical properties with ellipsometry is well established, such measurements on metals and alloys at elevated temperatures up to the liquid state are very challenging. To collect the optical properties of different metals and alloys like Al, Ti, Ag, Cu and steel in the solid and liquid state a custom-made high-temperature ellipsometer was used. The instrument is also used to investigate the influence of curved and rough surfaces which may occur due to the heating of the samples during the ellipsometric measurements

QuantiNemo 2: a Swiss knife to simulate complex demographic and genetic scenarios, forward and backward in time.

QuantiNemo 2 is a stochastic simulation program for quantitative population genetics. It was developed to investigate the effects of selection, mutation, recombination and drift on quantitative traits and neutral markers in structured populations connected by migration and located in heterogeneous habitats. A specific feature is that it allows to switch between an individual-based full-featured mode and a population-based faster mode. Several demographic, genetic and selective parameters can be fine-tuned in QuantiNemo 2: population, selection, trait(s) architecture, genetic map for QTL and/or markers, environment, demography and mating system are the main features. QuantiNemo 2 is a C++ program with a source code available under the GNU General Public License version 3. Executables are provided for Windows, MacOS and Linux platforms, together with a comprehensive manual and tutorials illustrating its flexibility. The executable, manual and tutorial can be found on the website www2.unil.ch/popgen/softwares/quantinemo/, while the source code and user support are given through GitHub: github.com/jgx65/quantinemo. Supplementary data are available at Bioinformatics online

Visual Literacy of Molecular Biology Revealed through a Card-Sorting Task

Visual literacy, which is the ability to effectively identify, interpret, evaluate, use, and create images and visual media, is an important aspect of science literacy. As molecular processes are not directly observable, researchers and educators rely on visual representations (e.g., drawings) to communicate ideas in biology. How learners interpret and organize those numerous diagrams is related to their underlying knowledge about biology and their skills in visual literacy. Furthermore, it is not always obvious how and why learners interpret diagrams in the way they do (especially if their interpretations are unexpected), as it is not possible to “see” inside the minds of learners and directly observe the inner workings of their brains. Hence, tools that allow for the investigation of visual literacy are needed. Here, we present a novel card-sorting task based on visual literacy skills to investigate how learners interpret and think about DNA-based concepts. We quantified differences in performance between groups of varying expertise and in pre- and postcourse settings using percentages of expected card pairings and edit distance to a perfect sort. Overall, we found that biology experts organized the visual representations based on deep conceptual features, while biology learners (novices) more often organized based on surface features, such as color and style. We also found that students performed better on the task after a course in which molecular biology concepts were taught, suggesting the activity is a useful and valid tool for measuring knowledge. We have provided the cards to the community for use as a classroom activity, as an assessment instrument, and/or as a useful research tool to probe student ideas about molecular biology