501 research outputs found

    The Sobering Failure of America\u27s War on Drugs : Free the P.O.W.s

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    Global observation of vertical-CLVD earthquakes at active volcanoes

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    Some of the largest and most anomalous volcanic earthquakes have non-double-couple focal mechanisms. Here, we investigate the link between volcanic unrest and the occurrence of non-double-couple earthquakes with dominant vertical tension or pressure axes, known as vertical compensated-linear-vector-dipole (vertical-CLVD) earthquakes. We determine focal mechanisms for 313 target earthquakes from the standard and surface wave catalogs of the Global Centroid Moment Tensor Project and identify 86 shallow 4.3 ≤ MW ≤ 5.8 vertical-CLVD earthquakes located near volcanoes that have erupted in the last ~100 years. The majority of vertical-CLVD earthquakes occur in subduction zones in association with basaltic-to-andesitic stratovolcanoes or submarine volcanoes, although vertical-CLVD earthquakes are also located in continental rifts and in regions of hot spot volcanism. Vertical-CLVD earthquakes are associated with many types of confirmed or suspected eruptive activity at nearby volcanoes, including volcanic earthquake swarms as well as effusive and explosive eruptions and caldera collapse. Approximately 70% of all vertical-CLVD earthquakes studied occur during episodes of documented volcanic unrest at a nearby volcano. Given that volcanic unrest is underreported, most shallow vertical-CLVD earthquakes near active volcanoes are likely related to magma migration or eruption processes. Vertical-CLVD earthquakes with dominant vertical pressure axes generally occur after volcanic eruptions, whereas vertical-CLVD earthquakes with dominant vertical tension axes generally occur before the start of volcanic unrest. The occurrence of these events may be useful for identifying volcanoes that have recently erupted and those that are likely to erupt in the future

    Spatial and temporal variations in Greenland glacial-earthquake activity, 1993–2010

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    Glacial earthquakes are anomalous earthquakes associated with large ice-loss events occurring at marine-terminating glaciers, primarily in Greenland. They are detectable teleseismically, and a proper understanding of the source mechanism may provide a remote-sensing tool to complement glaciological observations of these large outlet glaciers. We model teleseismic surface-wave waveforms to obtain locations and centroid–single-force source parameters for 121 glacial earthquakes occurring in Greenland during the period 2006–2010. We combine these results with those obtained by previous workers to analyze spatial and temporal trends in glacial-earthquake occurrence over the 18-year period from 1993–2010. We also examine earthquake occurrence at six individual glaciers, comparing the earthquake record to independently obtained observations of glacier change. Our findings confirm the inference that glacial-earthquake seismogenesis occurs through the capsize of large, newly calved icebergs. We find a close correspondence between episodes of glacier retreat, thinning, and acceleration and the timing of glacial earthquakes, and document the northward progression of glacial earthquakes on Greenland's west coast over the 18-year observing period. Our results also show that glacial earthquakes occur when the termini of the source glaciers are very close to the glacier grounding line, i.e., when the glaciers are grounded or nearly grounded

    Earthquake source parameters for the 2010 western Gulf of Aden rifting episode

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    On 2010 November 14, an intense swarm of earthquakes began in the western Gulf of Aden. Within a 48-hr period, 82 earthquakes with magnitudes between 4.5 and 5.5 were reported along an ∼80-km-long segment of the east-west trending Aden Ridge, making this swarm one of the largest ever observed in an extensional oceanic setting. In this study, we calculate centroid-moment-tensor solutions for 110 earthquakes that occurred between 2010 November and 2011 April. Over 80 per cent of the cumulative seismic moment results from earthquakes that occurred within 1 week of the onset of the swarm. We find that this sequence has a b-value of ∼1.6 and is dominated by normal-faulting earthquakes that, early in the swarm, migrate westwards with time. These earthquakes are located in rhombic basins along a section of the ridge that was previously characterized by low levels of seismicity and a lack of recent volcanism on the seafloor. Body-wave modelling demonstrates that the events occur in the top 2-3 km of the crust. Nodal planes of the normal-faulting earthquakes are consistent with previously mapped faults in the axial valley. A small number of strike-slip earthquakes observed between two basins near 44°E, where the axial valley changes orientation, depth and width, likely indicate the presence of an incipient transform fault and the early stages of ridge-transform segmentation. The direction of extension accommodated by the earthquakes is intermediate between the rift orthogonal and the direction of relative motion between the Arabian and Somalian plates, consistent with the oblique style of rifting occurring along the slow-spreading Aden Ridge. The 2010 swarm shares many characteristics with dyke-induced rifting episodes from both oceanic and continental settings. We conclude that the 2010 swarm represents the seismic component of an undersea magmatic rifting episode along the nascent Aden Ridge, and attribute the large size of the earthquakes to the combined effects of the slow spreading rate, relatively thick crust and recent quiescence. We estimate that the rifting episode was caused by dyke intrusions that propagated laterally for 12-18 hr, accommodating ∼1-14 m of opening or ∼85-800 yr of spreading along this section of the ridge. Our findings demonstrate the westward propagation of active seafloor spreading into this section of the western Gulf of Aden and illustrate that deformation at the onset of seafloor spreading may be accommodated by discrete episodes of faulting and magmatism. A comparison with similar sequences on land suggests that the 2010 episode may be only the first of several dyke-induced rifting episodes to occur in the western Gulf of Aden

    Functional significance may underlie the taxonomic utility of single amino acid substitutions in conserved proteins

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    We hypothesized that some amino acid substitutions in conserved proteins that are strongly fixed by critical functional roles would show lineage-specific distributions. As an example of an archetypal conserved eukaryotic protein we considered the active site of ß-tubulin. Our analysis identified one amino acid substitution—ß-tubulin F224—which was highly lineage specific. Investigation of ß-tubulin for other phylogenetically restricted amino acids identified several with apparent specificity for well-defined phylogenetic groups. Intriguingly, none showed specificity for “supergroups” other than the unikonts. To understand why, we analysed the ß-tubulin Neighbor-Net and demonstrated a fundamental division between core ß-tubulins (plant-like) and divergent ß-tubulins (animal and fungal). F224 was almost completely restricted to the core ß-tubulins, while divergent ß-tubulins possessed Y224. Thus, our specific example offers insight into the restrictions associated with the co-evolution of ß-tubulin during the radiation of eukaryotes, underlining a fundamental dichotomy between F-type, core ß-tubulins and Y-type, divergent ß-tubulins. More broadly our study provides proof of principle for the taxonomic utility of critical amino acids in the active sites of conserved proteins

    Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site

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    Development of antimitotic binding to the colchicine-binding site for the treatment of cancer is rapidly expanding. Numerous antimicrotubule agents are prepared every year, and the determination of their binding affinity to tubulin requires the use of purified tubulins and radiolabeled ligands. Such a procedure is costly and time-consuming and therefore is limited to the most promising candidates. Here, we report a quick and inexpensive method that requires only usual laboratory resources to assess the binding of antimicrotubules to colchicine-binding site. The method is based on the ability of N,N'-ethylene-bis(iodoacetamide) (EBI) to crosslink in living cells the cysteine residues at position 239 and 354 of β-tubulin, residues which are involved in the colchicine-binding site. The β-tubulin adduct formed by EBI is easily detectable by Western blot as a second immunoreacting band of β-tubulin that migrates faster than β-tubulin. The occupancy of colchicine-binding site by pertinent antimitotics inhibits the formation of the EBI: β-tubulin adduct, resulting in an assay that allows the screening of new molecules targeting this binding site
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