Potential impacts of iron biofortification in India

Iron deficiency is a widespread nutritional problem in developing countries, causing impaired physical activity and cognitive development, as well as maternal mortality. Although food fortification and supplementation programmes have been effective in some countries, their overall success remains limited. Biofortification, that is, breeding crops for higher micronutrient content, is a relatively new approach. We propose a methodology for ex-ante impact assessment of iron biofortification, which builds on disability-adjusted life years (DALYs) and a large household data set. Our analysis of iron-rich rice and wheat in India indicates sizeable potential health benefits. The cost-effectiveness of iron biofortification compares favourably with other interventions

The impact of maternal micronutrient supplementation on early neonatal morbidity

Many women throughout the world survive on diets of poor quality, and deficiencies in vitamins, minerals and trace elements are common in many developing countries. The effect of this poor nutritional status is a particular concern when the additional demands of pregnancy and lactation expose both the mother and her newborn infant to increased risk of adverse consequence.1 In response to this, the international community proposed about 10 years ago that a multiple micronutrient supplement be developed for widespread use as a dietary supplement during pregnancy.2 Since that time a number of large-scale randomised controlled trials have been carried out in which maternal supplementation with multiple micronutrients during pregnancy has been assessed for an effect on maternal mortality and morbidity, birth weight and later growth, morbidity and survival. <br/

A meta-analysis of community-based studies on quality protein maize

Biofortification, or the improvement of nutritional quality in food crops, is a promising strategy to combat undernutrition, particularly among the rural poor in developing countries. However, traditional methods of impact assessment are inadequate for biofortified crops, as they do not consider their nutritional benefits. Evidence for the nutritional impact of maize varieties with improved protein quality, collectively known as quality protein maize (QPM), was evaluated using meta-analysis of randomized, controlled studies in target communities.A new and generalizable effect size was proposed to quantify the impact of QPM on a key outcome, child growth. The results indicated that consumption of QPM instead of conventional maize leads to a 12% (95% CI: 7–18%) increase in the rate of growth in weight and a 9% (95% CI: 6–15%) increase in the rate of growth in height in infants and young children with mild to moderate undernutrition from populations in which maize is the major staple food. The proposed effect size and use of bootstrapping to determine statistical significance addressed some methodological limitations in the existing studies

Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD)

Developmental origins of health and disease (DOHaD) focuses on the earliest stages of human development, and provides a novel paradigm to complement other strategies for lifelong prevention of common chronic health conditions. The 3 International Congress on DOHaD, held in 2005, retained the most popular features from the first two biannual Congresses, while adding a number of innovations, including increased emphasis on implications of DOHaD for the developing world; programs for trainees and young investigators; and new perspectives, including developmental plasticity, influences of social hierarchies, effects of prematurity, and populations in transition. Emerging areas of science included, first, the controversial role of infant weight gain in predicting adult obesity, diabetes, and cardiovascular disease. Second, in the era of epidemic obesity, paying attention to the over-nourished fetus is as important as investigating the growth retarded one. Third, environmental toxins appear to have abroad range of long-lasting effects on the developing human. Fourth, epigenetic mechanisms could unite several strands of human and animal observations, and explain how genetically identical individuals raised in similar postnatal environments can nonetheless develop widely differing phenotypes. Improving the environment to which an individual is exposed during development may be as important as any other public health effort to enhance population health world wide