Acetylcholinesterase Inhibitory Activities And Lc-Ms Analysis Of The Antioxidant Ferula Caspica M. Bieb. And F. Halophila Pesmen Extracts

The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Pesmen. Antioxidant capacities and total phenolic contents of the plants' extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.WoSScopu

Effect of essential oils and isolated compounds from Pimpinella species on NF-kappa B: A target for antiinflammatory therapy

WOS: 000248556900006PubMed ID: 17450505Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-kappa B mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF-kappa B mediated transcription. Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC50 values of 2, 3 and 6 mu g/mL, respectively. Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3methyloxiranyl)phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-kappa B mediated transcription with IC50 values of 5.5, 1.2, 0.01, 3.6 and 11 mu g/mL, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation. Copyright (c) 2007 John Wiley & Sons, Ltd