Separation of Parallel Encoded Complex-Valued Slices (SPECS) From A Single Complex-Valued Aliased Coil Image

Purpose Achieving a reduction in scan time with minimal inter-slice signal leakage is one of the significant obstacles in parallel MR imaging. In fMRI, multiband-imaging techniques accelerate data acquisition by simultaneously magnetizing the spatial frequency spectrum of multiple slices. The SPECS model eliminates the consequential inter-slice signal leakage from the slice unaliasing, while maintaining an optimal reduction in scan time and activation statistics in fMRI studies. Materials and Methods When the combined k-space array is inverse Fourier reconstructed, the resulting aliased image is separated into the un-aliased slices through a least squares estimator. Without the additional spatial information from a phased array of receiver coils, slice separation in SPECS is accomplished with acquired aliased images in shifted FOV aliasing pattern, and a bootstrapping approach of incorporating reference calibration images in an orthogonal Hadamard pattern. Result The aliased slices are effectively separated with minimal expense to the spatial and temporal resolution. Functional activation is observed in the motor cortex, as the number of aliased slices is increased, in a bilateral finger tapping fMRI experiment. Conclusion The SPECS model incorporates calibration reference images together with coefficients of orthogonal polynomials into an un-aliasing estimator to achieve separated images, with virtually no residual artifacts and functional activation detection in separated images

On Functional Activations in Deep Neural Networks

Background: Deep neural networks have proven to be powerful computational tools for modeling, prediction, and generation. However, the workings of these models have generally been opaque. Recent work has shown that the performance of some models are modulated by overlapping functional networks of connections within the models. Here the techniques of functional neuroimaging are applied to an exemplary large language model to probe its functional structure. Methods: A series of block-designed task-based prompt sequences were generated to probe the Facebook Galactica-125M model. Tasks included prompts relating to political science, medical imaging, paleontology, archeology, pathology, and random strings presented in an off/on/off pattern with prompts about other random topics. For the generation of each output token, all layer output values were saved to create an effective time series. General linear models were fit to the data to identify layer output values which were active with the tasks. Results: Distinct, overlapping networks were identified with each task. Most overlap was observed between medical imaging and pathology networks. These networks were repeatable across repeated performance of related tasks, and correspondence of identified functional networks and activation in tasks not used to define the functional networks was shown to accurately identify the presented task. Conclusion: The techniques of functional neuroimaging can be applied to deep neural networks as a means to probe their workings. Identified functional networks hold the potential for use in model alignment, modulation of model output, and identifying weights to target in fine-tuning

Variable Resolution Sampling and Deep Learning-Based Image Recovery for Faster Multi-Spectral Imaging Near Metal Implants

Purpose: In multi-spectral imaging (MSI), several fast spin echo volumes with discrete Larmor frequency offsets are acquired in an interleaved fashion with multiple concatenations. Here, a variable resolution (VR) method to nearly halve scan time is proposed by only acquiring low resolution autocalibrating signal in half of the concatenations. Methods: Knee MSI datasets were retrospectively undersampled with the proposed variable resolution sampling scheme. A U-Net model was trained to predict the full-resolution images from the VR input. Image quality was assessed in 10 test subjects. Results: Spectral bin-combined images produced with the proposed variable resolution sampling with deep learning reconstruction appear to be of high quality and exhibited a median structural image similarity of 0.984 across test subjects and slices. Conclusion: The proposed variable resolution sampling method shows promise for drastically reducing the time it takes to collect multi-spectral imaging data near metallic implants. Further studies will rigorously examine its clinical utility across multiple implant scenarios

The Association Between Persistent White-Matter Abnormalities and Repeat Injury After Sport-Related Concussion

Objective: A recent systematic review determined that the physiological effects of concussion may persist beyond clinical recovery. Preclinical models suggest that ongoing physiological effects are accompanied by increased cerebral vulnerability that is associated with risk for subsequent, more severe injury. This study examined the association between signal alterations on diffusion tensor imaging following clinical recovery of sport-related concussion in athletes with and without a subsequent second concussion. Methods: Average mean diffusivity (MD) was calculated in a region of interest (ROI) in which concussed athletes (n = 82) showed significantly elevated MD acutely after injury (<48 h), at an asymptomatic time point, 7 days post-return to play (RTP), and 6 months relative to controls (n = 69). The relationship between MD in the identified ROI and likelihood of sustaining a subsequent concussion over a 1-year period was examined with a binary logistic regression (re-injured, yes/no). Results: Eleven of 82 concussed athletes (13.4%) sustained a second concussion within 12 months of initial injury. Mean MD at 7 days post-RTP was significantly higher in those athletes who went on to sustain a repeat concussion within 1 year of initial injury than those who did not (p = 0.048; d = 0.75). In this underpowered sample, the relationship between MD at 7 days post-RTP and likelihood of sustaining a secondary injury approached significance [χ2 (1) = 4.17, p = 0.057; B = 0.03, SE = 0.017; OR = 1.03, CI = 0.99, 1.07]. Conclusions: These preliminary findings raise the hypothesis that persistent signal abnormalities in diffusion imaging metrics at RTP following concussion may be predictive of a repeat concussion. This may reflect a window of cerebral vulnerability or increased susceptibility following concussion, though understanding the clinical significance of these findings requires further study