Multiple parietal reach regions in humans: cortical representations for visual and proprioceptive feedback during on-line reaching

Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target. Another is proprioception from the moving limb, which informs the brain of the location of the hand relative to the target even when the hand is not visible. Where these two sources of information are represented in the human brain is unknown. In the present study, we investigated the cortical representations for reaching with or without visual feedback from the moving hand, using functional magnetic resonance imaging. To identify reach-dominant areas, we compared reaching with saccades. Our results show that a reach-dominant region in the anterior precuneus (aPCu), extending into medial intraparietal sulcus, is equally active in visual and nonvisual reaching. A second region, at the superior end of the parieto-occipital sulcus (sPOS), is more active for visual than for nonvisual reaching. These results suggest that aPCu is a sensorimotor area whose sensory input is primarily proprioceptive, while sPOS is a visuomotor area that receives visual feedback during reaching. In addition to the precuneus, medial, anterior intraparietal, and superior parietal cortex were also activated during both visual and nonvisual reaching, with more anterior areas responding to hand movements only and more posterior areas responding to both hand and eye movements. Our results suggest that cortical networks for reaching are differentially activated depending on the sensory conditions during reaching. This indicates the involvement of multiple parietal reach regions in humans, rather than a single homogenous parietal reach region

Assessing Sandhill Crane Roosting Habitat along the Platte River, Nebraska

Each spring approximately 500,000 sandhill cranes and some endangered whooping cranes use the Central Platte River Valley in Nebraska as a staging habitat during their migration north to breeding and nesting grounds in Canada, Alaska, and the Siberian Arctic. Over the last century changes in the flow of the river have altered the river channels and the distribution of roost sites. USGS researchers studied linkages between water flow, sediment supply, channel morphology, and preferred sites for crane roosting. These results are useful for estimating crane populations and for providing resource managers with techniques to understand crane habitats

Development of a sheep platform and behavioral monitoring methods for assessing deep brain stimulation therapies and devices for movement disorders

Preclinical animal models are essential for successful development of safe and effective commercialized CNS therapies. Objective data from animal models establish proof of concept evidence and provide critical inputs to the design of later phase clinical studies. In medical device development, a large animal with an intact nervous system is preferred because it permits use of human-scaled devices and controlled testing that cannot be replicated with computer modeling or bench-testing. Therefore, we established an in-house sheep platform for early-phase testing of deep brain stimulation (DBS) therapy concepts and devices within the movement disorders space. In twelve animals commercial DBS leads with four active contacts were targeted to the subthalamic nucleus (STN), a common stimulation target in Parkinson disease. Overall, DBS lead implantation was not associated with remarkable neurological or histopathological complications. Assessments of targeting using standard comparisons of pre and post-operative brain images indicated that accuracy was comparable to clinical experience. Methods were developed to quantitatively assess motor behavior of chronically-implanted animals in the awake state. In open and blinded settings, we consistently found that motor behavior responses to STN stimulation significantly depended on the stimulation contact selected and parameters tested, including voltage, pulse width and frequency. Quantitative electromyographic assessments confirmed the motor behavior findings. This work establishes in-house capabilities for controlled testing of emerging DBS therapy concepts and device prototypes. Further work is ongoing to test prototype devices and develop additional objective physiological monitoring methods and biomarkers

A Composite Little Higgs Model

We describe a natural UV complete theory with a composite little Higgs. Below a TeV we have the minimal Standard Model with a light Higgs, and an extra neutral scalar. At the TeV scale there are additional scalars, gauge bosons, and vector-like charge 2/3 quarks, whose couplings to the Higgs greatly reduce the UV sensitivity of the Higgs potential. Stabilization of the Higgs mass squared parameter, without finetuning, occurs due to a softly broken shift symmetry--the Higgs is a pseudo Nambu-Goldstone boson. Above the 10 TeV scale the theory has new strongly coupled interactions. A perturbatively renormalizable UV completion, with softly broken supersymmetry at 10 TeV is explicitly worked out. Our theory contains new particles which are odd under an exact "dark matter parity", (-1)^{(2S+3B+L)}. We argue that such a parity is likely to be a feature of many theories of new TeV scale physics. The lightest parity odd particle, or "LPOP", is most likely a neutral fermion, and may make a good dark matter candidate, with similar experimental signatures to the neutralino of the MSSM. We give a general effective field theory analysis of the calculation of corrections to precision electroweak observables.Comment: 28 page

Regional femoral bone blood flow rates in laying and non-laying chickens estimated with fluorescent microspheres

The metabolic rate of vertebrate bone tissue is related to bone growth, repair and homeostasis, which are all dependent on life stage. Bone metabolic rate is difficult to measure directly, but absolute blood flow rate (Q̇) should reflect local tissue oxygen requirements. A recent 'foramen technique' has derived an index of blood flow rate (Qi) by measuring nutrient foramen sizes of long bones. Qi is assumed to be proportional to Q̇, however, the assumption has never been tested. This study used fluorescent microsphere infusion to measure femoral bone Q̇ in anaesthetised non-laying hens, laying hens and roosters. Mean cardiac output was 338±38 ml min-1 kg-1, and the two femora received 0.63±0.10 % of this. Laying hens had higher wet bone mass-specific Q̇ to femora (0.23±0.09 ml min-1 g-1) than the non-laying hens (0.12±0.06 ml min-1 g-1) and roosters (0.14±0.04 ml min-1 g-1), presumably associated with higher bone calcium mobilization during eggshell production. Estimated metabolic rate of femoral bone was 0.019 ml O2 min-1 g-1. Femoral Q̇ increased significantly with body mass, but was not correlated with nutrient foramen radius (r), probably due to a narrow range in foramen radius. Over all 18 chickens, femoral shaft Q̇/r was 1.07±0.30 ml min-1 mm-1. Mean Qi in chickens was significantly higher than predicted by an allometric relationship for adult cursorial bird species, possibly because the birds were still growing.Qiaohui Hu, Thomas J. Nelson and Roger S. Seymou

The Littlest Higgs

We present an economical theory of natural electroweak symmetry breaking, generalizing an approach based on deconstruction. This theory is the smallest extension of the Standard Model to date that stabilizes the electroweak scale with a naturally light Higgs and weakly coupled new physics at TeV energies. The Higgs is one of a set of pseudo Goldstone bosons in an $SU(5)/SO(5)$ nonlinear sigma model. The symmetry breaking scale $f$ is around a TeV, with the cutoff \Lambda \lsim 4\pi f \sim 10 TeV. A single electroweak doublet, the ``little Higgs'', is automatically much lighter than the other pseudo Goldstone bosons. The quartic self-coupling for the little Higgs is generated by the gauge and Yukawa interactions with a natural size $O(g^2,\lambda_t^2)$, while the top Yukawa coupling generates a negative mass squared triggering electroweak symmetry breaking. Beneath the TeV scale the effective theory is simply the minimal Standard Model. The new particle content at TeV energies consists of one set of spin one bosons with the same quantum numbers as the electroweak gauge bosons, an electroweak singlet quark with charge 2/3, and an electroweak triplet scalar. One loop quadratically divergent corrections to the Higgs mass are cancelled by interactions with these additional particles.Comment: 15 pages. References added. Corrected typos in the discussion of the top Yukawa couplin

The Minimal Moose for a Little Higgs

Recently a new class of theories of electroweak symmetry breaking have been constructed. These models, based on deconstruction and the physics of theory space, provide the first alternative to weak-scale supersymmetry with naturally light Higgs fields and perturbative new physics at the TeV scale. The Higgs is light because it is a pseudo-Goldstone boson, and the quadratically divergent contributions to the Higgs mass are cancelled by new TeV scale ``partners'' of the {\em same} statistics. In this paper we present the minimal theory space model of electroweak symmetry breaking, with two sites and four link fields, and the minimal set of fermions. There are very few parameters and degrees of freedom beyond the Standard Model. Below a TeV, we have the Standard Model with two light Higgs doublets, and an additional complex scalar weak triplet and singlet. At the TeV scale, the new particles that cancel the 1-loop quadratic divergences in the Higgs mass are revealed. The entire Higgs potential needed for electroweak symmetry breaking--the quartic couplings as well as the familiar negative mass squared--can be generated by the top Yukawa coupling, providing a novel link between the physics of flavor and electroweak symmetry breaking.Comment: 15 pages. References added. Included clarifying comments on the origin of quartic couplings, and on power-counting. More elegant model for generating Higgs potential from top Yukawa coupling presente

Intersubband plasmons in quasi-one-dimensional electron systems on a liquid helium surface

The collective excitation spectra are studied for a multisubband quasi-one-dimensional electron gas on the surface of liquid helium. Different intersubband plasmon modes are identified by calculating the spectral weight function of the electron gas within a 12 subband model. Strong intersubband coupling and depolarization shifts are found. When the plasmon energy is close to the energy differences between two subbands, Landau damping in this finite temperature system leads to plasmon gaps at small wavevectors.Comment: To be published as a Rapid Communication in Phys. Rev.

The 1:1 resonance in Extrasolar Systems: Migration from planetary to satellite orbits

We present families of symmetric and asymmetric periodic orbits at the 1/1 resonance, for a planetary system consisting of a star and two small bodies, in comparison to the star, moving in the same plane under their mutual gravitational attraction. The stable 1/1 resonant periodic orbits belong to a family which has a planetary branch, with the two planets moving in nearly Keplerian orbits with non zero eccentricities and a satellite branch, where the gravitational interaction between the two planets dominates the attraction from the star and the two planets form a close binary which revolves around the star. The stability regions around periodic orbits along the family are studied. Next, we study the dynamical evolution in time of a planetary system with two planets which is initially trapped in a stable 1/1 resonant periodic motion, when a drag force is included in the system. We prove that if we start with a 1/1 resonant planetary system with large eccentricities, the system migrates, due to the drag force, {\it along the family of periodic orbits} and is finally trapped in a satellite orbit. This, in principle, provides a mechanism for the generation of a satellite system: we start with a planetary system and the final stage is a system where the two small bodies form a close binary whose center of mass revolves around the star.Comment: to appear in Cel.Mech.Dyn.Ast

Associations between blood sex steroid concentrations and risk of major adverse cardiovascular events in healthy older women in Australia: a prospective cohort substudy of the ASPREE trial

Background: Blood testosterone concentrations in women decline during the reproductive years and reach a nadir in the seventh decade, after which concentrations increase and are restored to those of reproductive-aged women early in the eighth decade. We aimed to establish the association between the concentration of testosterone in the blood and risk of major adverse cardiovascular events (MACE) and all-cause mortality in healthy older women. Methods: SHOW was a prospective cohort substudy of the longitudinal randomised ASPREE trial. Eligible participants were women aged at least 70 years from Australia with unimpaired cognition, no previous MACE, and a life expectancy of at least 5 years. Participants who were receiving hormonal or steroid therapy were ineligible for inclusion. We measured serum concentrations of sex steroids with liquid chromatography–tandem mass spectrometry and of SHBG with immunoassay. We compared lower concentrations of sex hormones with higher concentrations using four quartiles. Primary endpoints were risk of MACE and all-cause mortality, the associations of which with sex steroid concentrations were assessed using Cox proportional hazards regression that included age, body-mass index, smoking status, alcohol consumption, diabetes, hypertension, dyslipidaemia, impaired renal function, and treatment allocation in the ASPREE trial (aspirin vs placebo). ASPREE is registered with ClinicalTrials.gov, NCT01038583. Findings: Of the 9180 women recruited to the ASPREE trial between March 10, 2010, and Dec 31 2014, 6358 participants provided sufficient biobank samples at baseline and 5535 were included in the final analysis. Median age at entry was 74·0 years (IQR 71·7–77·7). During a median 4·4 years of follow-up (24 553 person-years), 144 (2·6%) women had a first MACE (incidence 5·9 per 1000 person-years). During a median 4·6 years of follow-up (3·8–5·6), 200 women died (7·9 per 1000 person-years). In the fully adjusted models, higher concentrations of testosterone were associated with a lower incidence of MACE (quartile 4 vs quartile 1: hazard ratio 0·57 [95% CI 0·36–0·91]; p=0·02), as were higher concentrations of DHEA (quartile 4 vs quartile 1: 0·61 [0·38–0·97]; p=0·04). For oestrone, a lower risk of MACE was seen for concentrations in quartile 2 only, compared with quartile 1 (0·55 [0·33–0·92]; p=0·02). In fully adjusted models, no association was seen between SHBG and MACE, or between any hormone or SHBG and all-cause mortality. Interpretation: Blood concentrations of testosterone and DHEA above the lowest quartile in older women were associated with a reduced risk of a first-ever MACE. Given that the physiological effects of DHEA are mediated through its steroid metabolites, if the current findings were to be replicated, trials investigating testosterone therapy for the primary prevention of ischaemic cardiovascular disease events in older women would be warranted. Funding: The National Health and Medical Research Council of Australia, US National Institute on Aging, the Victorian Cancer Agency, the Commonwealth Scientific and Industrial Research Organisation, and Monash University