Using Ciliate Operations to Construct Chromosome Phylogenies

Whole genome sequencing has revealed several examples where genomes of different species are related by permutation. The number of certain types of rearrangements needed to transform one permuted list into another can measure the distance between such lists. Using an algorithm based on three basic DNA editing operations suggested by a model for ciliate micronuclear decryption, this study defines the distance between two permutations to be the number of ciliate operations the algorithm performs during such a transformation. Combining well-known clustering methods with this distance function enables one to construct corresponding phylogenies. These ideas are illustrated by exploring the phylogenetic relationships among the chromosomes of eight fruit fly (Drosophila) species, using the well-known UPGMA algorithm on the distance function provided by the ciliate operations

‘Just gripping my heart and squeezing’:Naming and explaining the emotional experience of receiving bad news in the paediatric oncology setting

Objective To explore recipients’ perspectives on the range and origins of their emotional experiences during their ‘bad news’ consultations. Methods Participants were four bereaved families of children who had changed from active treatment to palliative care in paediatric oncology. Data was collected using emotional touchpoint storytelling. The names (descriptors) given to the emotional experiences were linguistically classified. Explanations of their perceived origins were examined using applied thematic analysis. Results 26 descriptors were given, relating to bodily sensations, affective states, evaluations and cognitive conditions. Three themes were identified in the origins of these experiences – ‘becoming aware’, ‘the changes’ and ‘being in this situation’. Parents described strong emotional displays during the consultation including physical collapse. These related to the internal process of ‘becoming aware’. Three descriptors were given as originating from the clinicians and their delivery of the news – ‘supported’, ‘included’, ‘trusting’. Conclusions Recipients perceive their emotional experiences as mainly originating from the news itself, and perceived consequences of it, rather than its delivery. Strong emotional reactions during the interaction are not necessarily an indicator of ineffectual delivery. Practice Implications Findings offer a thematic framing that may support and deepen practitioners’ understanding of recipients’ emotional reactions during bad news consultations

Fossil tree hollows from a late Permian forest of the Matinde Formation (Tete, Mozambique)

Fossil tree hollows are seldom described in the literature and can often be elusive to the field paleobotanist. However, these structures may provide unique paleoecological, environmental and tree life history information that are essential for a more complete understanding of ancient forests. A stump from the ‘late Permian’ (Wuchiapingian–Changhsingian) of the Mágoè Fossil Forest in Mozambique (Tete Province) provides a rare example of fossilized tree hollows. These hollows were found near the base of the tree and are subcircular in shape, ranging between ~1.3 and 3.5 cm in diameter. Although thirty-one trees were densely sampled (i.e. no fossil trees were excluded from a given area, in our case ~2650m2) and inspected at the Mágoè Fossil Forest, only one (PPM2017-31) exhibited tree hollows, highlighting the scarcity of these structures in this fossil forest. In modern forests tree hollows are more likely to be found in old trees, likewise PPM2017-31 was among the largest trees found in the sample, suggesting this was an old tree. The subcircular morphology of the tree hollows indicates they resulted from fungal/bacterial activity rather than from a fire.Museu Nacional de Geologia Fundação para a Ciência e a Tecnologia (SFRH/BPD/96205/2013) FCT - AGA KHAN Development Network grant number 333206718 National Geographic Society grant number CP-109R-17JNC201

From Human-Systems Integration to Human-Systems Inclusion for Use-Centred Inclusive Manufacturing Control Systems

The paper discusses about human-systems inclusion as a new way to take into account human factors on systems engineering. This process applies not only principles from human-supported by automation but also those on automation-supported by human to improve autonomy between humans and machines and autonomy between people. The main concern of human-systems integration is the consideration of a low number of future users in the design process or of the feedback of a majority of users in the evaluation process. Human-system inclusion considers that the system has to take into account and adapt to all users whatever their social, economic, physical or cognitive state, or disability. The concept of “human in the loop” or of “human touch” is usually limited to the definition of the role of humans and machines. It does not consider dynamic variability of users and systems abilities, and anticipate the feasible development of autonomous machines by reducing progressively human engagement in the control and supervisory loop. The paper presents both integration and inclusion concepts for Industry 4.0, and then suggests some challenging perspectives for use-centred inclusive manufacturing control systems in terms of opportunities and threats

Family Stress and Parental Responses to Children’s Negative Emotions: Tests of the Spillover, Crossover, and Compensatory Hypotheses

The relations between 4 sources of family stress (marital dissatisfaction, home chaos, parental depressive symptoms, and job role dissatisfaction) and the emotion socialization practice of mothers’ and fathers’ responses to children’s negative emotions were examined. Participants included 101 couples with 7-year-old children. Dyadic analyses were conducted using the Actor–Partner Interdependence Model and relations were tested in terms of the spillover, crossover, and compensatory hypotheses. Results suggest that measures of family stress relate to supportive and nonsupportive parental responses, though many of these relations differ by parent gender. The results are discussed in terms of the 3 theoretical hypotheses, all of which are supported to some degree depending on the family stressor examined

Effect of Palliative Care–Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial

Family caregivers of patients with chronic critical illness experience significant psychological distress