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Farm Adjustment Possibilities to Increase Income in the Wellton-Mohawk District of Yuma County
This item is part of the Agricultural Experiment Station archive. It was digitized from a physical copy provided by the University Libraries at the University of Arizona. For more information, please email CALS Publications at [email protected]
Instrumental vetoes for transient gravitational-wave triggers using noise-coupling models: The bilinear-coupling veto
LIGO and Virgo recently completed searches for gravitational waves at their
initial target sensitivities, and soon Advanced LIGO and Advanced Virgo will
commence observations with even better capabilities. In the search for short
duration signals, such as coalescing compact binary inspirals or "burst"
events, noise transients can be problematic. Interferometric gravitational-wave
detectors are highly complex instruments, and, based on the experience from the
past, the data often contain a large number of noise transients that are not
easily distinguishable from possible gravitational-wave signals. In order to
perform a sensitive search for short-duration gravitational-wave signals it is
important to identify these noise artifacts, and to "veto" them. Here we
describe such a veto, the bilinear-coupling veto, that makes use of an
empirical model of the coupling of instrumental noise to the output strain
channel of the interferometric gravitational-wave detector. In this method, we
check whether the data from the output strain channel at the time of an
apparent signal is consistent with the data from a bilinear combination of
auxiliary channels. We discuss the results of the application of this veto on
recent LIGO data, and its possible utility when used with data from Advanced
LIGO and Advanced Virgo.Comment: Minor changes; To appear in Phys. Rev.
The Origin of the Intrinsic Scatter in the Relation Between Black Hole Mass and Bulge Luminosity for Nearby Active Galaxies
We investigate the origin of the intrinsic scatter in the correlation between
black hole mass (MBH) and bulge luminosity [L(bulge)] in a sample of 45
massive, local (z < 0.35) type~1 active galactic nuclei (AGNs). We derive MBH
from published optical spectra assuming a spherical broad-line region, and
L(bulge) from detailed two-dimensional decomposition of archival optical Hubble
Space Telescope images. AGNs follow the MBH-L(bulge) relation of inactive
galaxies, but the zero point is shifted by an average of \Delta log MBH ~ -0.3
dex. We show that the magnitude of the zero point offset, which is responsible
for the intrinsic scatter in the MBH-L(bulge) relation, is correlated with
several AGN and host galaxy properties, all of which are ultimately related to,
or directly impact, the BH mass accretion rate. At a given bulge luminosity,
sources with higher Eddington ratios have lower MBH. The zero point offset can
be explained by a change in the normalization of the virial product used to
estimate MBH, in conjunction with modest BH growth (~ 10%--40%) during the AGN
phase. Galaxy mergers and tidal interactions appear to play an important role
in regulating AGN fueling in low-redshift AGNs.Comment: To appear in ApJ; 67 pages, 56 figures, 4 tables, version with full
resolution figures at http://users.ociw.edu/mjkim/papers/scatter.pd
Metaplasticity in human primary somatosensory cortex: effects on physiology and tactile perception
Theta-burst stimulation (TBS) over human primary motor cortex evokes plasticity and metaplasticity, the latter contributing to the homeostatic balance of excitation and inhibition. Our knowledge of TBS-induced effects on primary somatosensory cortex (SI) is limited, and it is unknown whether TBS induces metaplasticity within human SI. Sixteen right-handed participants (6 females, mean age 23 yr) received two TBS protocols [continuous TBS (cTBS) and intermittent TBS (iTBS)] delivered in six different combinations over SI in separate sessions. TBS protocols were delivered at 30 Hz and were as follows: a single cTBS protocol, a single iTBS protocol, cTBS followed by cTBS, iTBS followed by iTBS, cTBS followed by iTBS, and iTBS followed by cTBS. Measures included the amplitudes of the first and second somatosensory evoked potentials (SEPs) via median nerve stimulation, their paired-pulse ratio (PPR), and temporal order judgment (TOJ). Dependent measures were obtained before TBS and at 5, 25, 50, and 90 min following stimulation. Results indicate similar effects following cTBS and iTBS; increased amplitudes of the second SEP and PPR without amplitude changes to SEP 1, and impairments in TOJ. Metaplasticity was observed such that TOJ impairments following a single cTBS protocol were abolished following consecutive cTBS protocols. Additionally, consecutive iTBS protocols altered the time course of effects when compared with a single iTBS protocol. In conclusion, 30-Hz cTBS and iTBS protocols delivered in isolation induce effects consistent with a TBS-induced reduction in intracortical inhibition within SI. Furthermore, cTBS- and iTBS-induced metaplasticity appear to follow homeostatic and nonhomeostatic rules, respectively
Genome-wide Association Mapping of Qualitatively Inherited Traits in a Germplasm Collection
Genome-wide association (GWA) has been used as a tool for dissecting the genetic architecture of quantitatively inherited traits. We demonstrate here that GWA can also be highly useful for detecting many major genes governing categorically defined phenotype variants that exist for qualitatively inherited traits in a germplasm collection. Genome-wide association mapping was applied to categorical phenotypic data available for 10 descriptive traits in a collection of ~13,000 soybean [Glycine max (L.) Merr.] accessions that had been genotyped with a 50,000 single nucleotide polymorphism (SNP) chip. A GWA on a panel of accessions of this magnitude can offer substantial statistical power and mapping resolution, and we found that GWA mapping resulted in the identification of strong SNP signals for 24 classical genes as well as several heretofore unknown genes controlling the phenotypic variants in those traits. Because some of these genes had been cloned, we were able to show that the narrow GWA mapping SNP signal regions that we detected for the phenotypic variants had chromosomal bp spans that, with just one exception, overlapped the bp region of the cloned genes, despite local variation in SNP number and nonuniform SNP distribution in the chip set
Experimental Study of the Inductance of Pinned Vortices in Superconducting YBa2Cu3O7-d Films
Using a two-coil mutual inductance method, we have measured the complex
resistivity, rho_v(T,Be), of pinned vortices in c-axis pulsed laser deposited
YBa2Cu3O7-d films with magnetic field Be applied perpendicular to the film. At
low frequencies, (<100 kHz), rho_v is inductive and is inversely proportional
to the Labusch parameter, the average vortex pinning force constant, kappa_exp.
The observed weakening of kappa_exp with Be is consistent with a simple model
based on linear pinning defects. Adding classical thermal fluctuations to the
model in a simple way describes the observed linear T dependence of rho_v,
below ~15 K and provides reasonable values for the effective radius (.3 nm to
>.8 nm) of the defects and the depth of the pinning potential. The success of
this model implies that thermal supercurrent (phase) fluctuations have their
full classical amplitude down to 5 K for frequencies below the characteristic
depinning frequency. To date, no sufficient theory exists to explain the data
between ~15 K and the vortex glass melting temperature.Comment: 31 pages, 8 figures. Subm. to PR
Swarm-NG: a CUDA Library for Parallel n-body Integrations with focus on Simulations of Planetary Systems
We present Swarm-NG, a C++ library for the efficient direct integration of
many n-body systems using highly-parallel Graphics Processing Unit (GPU), such
as NVIDIA's Tesla T10 and M2070 GPUs. While previous studies have demonstrated
the benefit of GPUs for n-body simulations with thousands to millions of
bodies, Swarm-NG focuses on many few-body systems, e.g., thousands of systems
with 3...15 bodies each, as is typical for the study of planetary systems.
Swarm-NG parallelizes the simulation, including both the numerical integration
of the equations of motion and the evaluation of forces using NVIDIA's "Compute
Unified Device Architecture" (CUDA) on the GPU. Swarm-NG includes optimized
implementations of 4th order time-symmetrized Hermite integration and mixed
variable symplectic integration, as well as several sample codes for other
algorithms to illustrate how non-CUDA-savvy users may themselves introduce
customized integrators into the Swarm-NG framework. To optimize performance, we
analyze the effect of GPU-specific parameters on performance under double
precision.
Applications of Swarm-NG include studying the late stages of planet
formation, testing the stability of planetary systems and evaluating the
goodness-of-fit between many planetary system models and observations of
extrasolar planet host stars (e.g., radial velocity, astrometry, transit
timing). While Swarm-NG focuses on the parallel integration of many planetary
systems,the underlying integrators could be applied to a wide variety of
problems that require repeatedly integrating a set of ordinary differential
equations many times using different initial conditions and/or parameter
values.Comment: Submitted to New Astronom
Beta oscillatory changes and retention of motor skills during practice in healthy subjects and in patients with Parkinson's disease
Recently we found that modulation depth of beta power during movement increases with practice over sensory-motor areas in normal subjects but not in patients with Parkinson's disease (PD). As such changes might reflect use-dependent modifications, we concluded that reduction of beta enhancement in PD represents saturation of cortical plasticity. A few questions remained open: What is the relation between these EEG changes and retention of motor skills? Would a second task exposure restore beta modulation enhancement in PD? Do practice-induced increases of beta modulation occur within each block? We thus recorded EEG in patients with PD and age-matched controls in two consecutive days during a 40-min reaching task divided in fifteen blocks of 56 movements each. The results confirmed that, with practice, beta modulation depth over the contralateral sensory-motor area significantly increased across blocks in controls but not in PD, while performance improved in both groups without significant correlations between behavioral and EEG data. The same changes were seen the following day in both groups. Also, beta modulation increased within each block with similar values in both groups and such increases were partially transferred to the successive block in controls, but not in PD. Retention of performance improvement was present in the controls but not in the patients and correlated with the increase in day 1 modulation depth. Therefore, the lack of practice-related increase beta modulation in PD is likely due to deficient potentiation mechanisms that permit between-block saving of beta power enhancement and trigger mechanisms of memory formation
Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.
Purpose: Abnormal activation of the NF-κB pathway induces a more aggressive phenotype of cutaneous melanoma. Understanding the mechanisms involved in melanoma NF-κB activation may identify novel targets for this pathway. KPC1, an E3 ubiquitin ligase, is a regulator of the NF-κB pathway. The objective of this study was to investigate the mechanisms regulating KPC1 expression and its clinical impact in melanoma.Experimental Design: The clinical impact of KPC1 expression and its epigenetic regulation were assessed in large cohorts of clinically well-annotated melanoma tissues (tissue microarrays; n = 137, JWCI cohort; n = 40) and The Cancer Genome Atlas database (TCGA cohort, n = 370). Using melanoma cell lines, we investigated the functional interactions between KPC1 and NF-κB, and the epigenetic regulations of KPC1, including DNA methylation and miRNA expression.Results: We verified that KPC1 suppresses melanoma proliferation by processing NF-κB1 p105 into p50, thereby modulating NF-κB target gene expression. Concordantly, KPC1 expression was downregulated in American Joint Committee on Cancer stage IV melanoma compared with early stages (stage I/II P = 0.013, stage III P = 0.004), and low KPC1 expression was significantly associated with poor overall survival in stage IV melanoma (n = 137; HR 1.810; P = 0.006). Furthermore, our data showed that high miR-155-5p expression, which is controlled by DNA methylation at its promoter region (TCGA; Pearson\u27s r -0.455; P \u3c 0.001), is significantly associated with KPC1 downregulation (JWCI; P = 0.028, TCGA; P = 0.003).Conclusions: This study revealed novel epigenetic regulation of KPC1 associated with NF-κB pathway activation, promoting metastatic melanoma progression. These findings suggest the potential utility of KPC1 and its epigenetic regulation as theranostic targets. Clin Cancer Res; 23(16); 4831-42. ©2017 AACR
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