Comparison the effectiveness of Emotion-Focused Couple and Acceptance and Commitment Therapies on Marital Forgiveness in Incompatible Couples

Background: Using effective interventions to reduce incompatibility among couples can play a role in preventing divorce in the family. The present study aimed to compare the effectiveness of emotion-focused couple therapy (EFCT) and acceptance and commitment therapy (ACT) on forgiveness in incompatible couples. Methods: The present research is a quasi-experimental study that was done on couples referred to a family therapy clinic in Torbat-e-Jam City. Here, 24 incompatible couples were selected through purposive methods and randomly replaced in three groups. The first and second groups (8 couples in each group) received emotion-focused couples and acceptance and commitment therapies, respectively, and the third group as control (8 couples) did not receive any intervention during the study period. All three groups were evaluated before and after the intervention with a standard questionnaire of Bagarozi forgiveness (2001). Data were analyzed through SPSS software version 20 and covariance analysis. Results: The findings revealed that both therapies of EFCT and ACT had a meaningful effect on forgiveness (P < 0.001, F = 41.73, and P = 0.031, F = 5.13; respectively); while the results indicated that the two groups under intervention have no significant difference in terms of effectiveness on the variable of forgiveness (P=0.63, F=0.23). Conclusion: According to the results and effectiveness of the two therapy groups, it is recommended to use a combination of approaches according to the therapeutic goals

Losartan inhibits sars-cov-2 replication in vitro

Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus. Methods: The dose-dependent inhibitory effect of losartan, in concentrations from 1μM to 100μM as determined by quantitative cell analysis combining fluorescence microscopy, image processing, and cellular measurements (Cellomics analysis) on SARS-CoV-2 replication was investigated in Vero E6 cells. The impact of losartan on deubiquitination and deISGylation of SARS-CoV-2 papain-like protease (PLpro) were also evaluated.  Results: Losartan reduced PLpro cleavage of tetraUbiquitin to diUbiquitin.  It was less effective in inhibiting PLpro’s cleavage of ISG15-AMC than Ubiquitin-AMC.  To determine if losartan inhibited SARS-CoV-2 replication, losartan treatment of SARS-CoV-2 infected Vero E6 was examined. Losartan treatment one hour prior to SARS-CoV-2 infection reduced levels of SARS-CoV-2 nuclear protein, an indicator of virus replication, by 80% and treatment one-hour post-infection decreased viral replication by 70%. Conclusion: Losartan was not an effective inhibitor of deubiquitinase or deISGylase activity of the PLpro but affected the SARS-CoV-2 replication of Vero E6 cells in vitro.  As losartan has a favorable safety profile and is currently available it has features necessary for efficacious drug repurposing and treatment of COVID-19

Are Losartan and Imatinib Effective Against SARS-CoV2 Pathogenesis? a Pathophysiologic-Based in Silico Study

COVID19 has spread all over the globe with ARDS as the most grave complicating factor in its mortality and morbidity. As there is not an effective anti-viral drug or an imminent vaccine against this virus we proposed a novel insight about cytokine storm-indiced ARDS in this disease and conducted an in silico study according to the pathophysiology of cytokine storm. We found that losartan and imatinib may break the life cycle of the virus to the degree that its affinity to ACE2 may decline, the function of papin-like protease disrupts, and the cytokine storm may subside, as well. This means that the death toll of the disease may decline sharply till a vaccine is produced in the near future. All the results should be validated in subclinical studies.</div

Program Reliability Estimation Tool By

Testing is a very demanding procedure in software production, that takes a lot of e ort, time and resources during both development and maintenance. Moreover, statistical testing is a very costly procedure, especially if high reliability requirements are placed on the software as in safety-critical, or safety-related software cases. The main question is when to stop testing, or how many tests are needed? Singh et al. [49], using the method of the negative binomial, developed a procedure for quantifying the reliability ofamodule. According to their approach, the number of tests can be computed based on hypothesis testing. We implemented this method for a reliability estimation of a program. In this work, a prototype black-box automated testing tool, called Program Re-liability Estimation Tool (PRET) was developed as a statistical test generator and reliability estimation tool based on an operational pro le (a proposed testing model) and negative binomial sampling. The tool has a command line user interface. The inputs to the PRET are: an integer (0 or 1) to choose the usage (0: only generate test cases, 1: does the testing process), the test speci cation context le name, the data le name, the program under test name, and the oracle name. PRET computes the number of test cases, generates test cases, runs the generated test cases, evaluates the result of each test run by using an oracle, and estimates the reliability ofthe program based on test results. ii Acknowledgements Iwould like to express my sincere and deepest thanks to Professor David L. Parnas for his guidance, insight, enthusiasm, encouragement and constant support throughout the preparation of this work. Iamvery grateful to Dr. Roman Viveros and Dr. Ridha Khedri for their support, time and their helpful comments on this thesis. sions. Iwould like to thank Dr. Dennis Peters for many helpful and encouraging discus-I would like to thank Mr. Ross Steingrimsson for testing the tool and his useful suggestions. I would like tothank Mrs. Doris Burns for all her help. Iwould like toacknowledge the nancial support of the Natural Sciences and En

Platelet-Rich Fibrin: An Autologous Fibrin Matrix in Surgical Procedures: A Case Report and Review of Literature

Introduction: The healing process after surgery is a challenging issue for surgeons. Various materials and techniques have been developed to facilitate this process and reduce its period. Fibrin adhesives are often used in cardiothoracic and vascular surgery to seal diffuse microvascular bleeding and in general and plastic surgery to seal wound borders. This Case report and literature review will introduce the various usages of platelet-rich fibrin in different surgical procedures and the method of producing the matrix. Case Report: A 24-year old man with periorbital skin avulsion treated with PRF membrane has been reported and discussed in this paper.  Conclusion: Platelet-rich fibrin is a natural autologous fibrin matrix, which can be produced with a simple blood sample and a table centrifuge. The material has been used in a wide range of surgical procedures to shorten the healing period and reduce post-surgical complications

S Protein, ACE2 and Host Cell Proteases in SARS-CoV-2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? A Narrative Review

Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly sought to unravel how the virus enters the host cells. Some proteins on each side of the interaction between the virus and the host cells are involved as the major contributors to this process: (1) the nano-machine spike protein on behalf of the virus, (2) angiotensin converting enzyme II, the mono-carboxypeptidase and the key component of renin angiotensin system on behalf of the host cell, (3) some host proteases and proteins exploited by SARS-CoV-2. In this review, the complex process of SARS-CoV-2 entrance into the host cells with the contribution of the involved host proteins as well as the sequential conformational changes in the spike protein tending to increase the probability of complexification of the latter with angiotensin converting enzyme II, the receptor of the virus on the host cells, are discussed. Moreover, the release of the catalytic ectodomain of angiotensin converting enzyme II as its soluble form in the extracellular space and its positive or negative impact on the infectivity of the virus are considered

Complications of Bilateral Sagittal Split Osteotomy in Patients with Mandibular Prognathism

Introduction: Bilateral sagittal split osteotomy (BSSO) of mandible is vastly used in treatment of mandibular deficiencies and discrepancies. Since this method could affect esthetic as well as function, evaluating these effects from various aspects is crucial. This study assessed the effects of this technique on the function of masseter muscle, jaw movements, and sensory changes along with failures in screws used for fixation. Methods: 48 patients with mandibular prognathism participated. Electromyography (EMG) of the masseter muscle; limits of jaw movements including maximum opening (MIO), protrusive (PM), lateral movements (LLE and LRE); presences of sensory changes and two point discrimination test; and number of removed screws were recorded at the baseline, 3 months, and 6 months after surgery. Results: EMG activity of masseter decreased significantly 3 months after the surgery. However, after 6 months the masseter activity revealed no statistically significant difference with baseline activity. There was a significant decrease in MIO and PM after 3 months. The 6 month measurement of MIO and PM was also lower than baseline. However, no difference was observed between LRE and LLE in both follow up sessions. Among 46 patients, 27 patients developed lip paresthesia 3 months after surgery. After 6 month, lip paresthesia remained in 11 patients. Among 276 screws used for fixation 3 screws removed due to exposure to oral cavity and 2 due to patient discomfort. Conclusion: As BSSO in patients with mandibular prognathism revealed temporary functional and sensory changes, it is a safe and appropriate method in orthognathic surgery

Periodontal problems following surgical extraction of impacted mandibular third molar teeth

Introduction:There are conflicting reports on the effects of surgical removal of impacted mandibular third molars on the periodontium of the adjacent teeth. The aim of this study was to compare the condition of the periodontium six months after extraction of impacted mandibular third molars with baseline values. Methods: Fifty patients with mesioangular impacted mandibular third molarsparticipated in this study. Probing depth (PD), Leo and Sillness' gingival index (GI), and clinical attachment level (CAL) in distobuccal, mid-distal, and distolingual surfaces of second molar teeth were assessed before surgical extraction of the third molars and 6 months later. To evaluate the changes in alveolar bone height (BH), two parallel PA radiographs obtained at the baseline and follow-up session. Data was analyzed with SPSS 11.0 software atthe confidence interval of 95%. Results: Thirty-eight females and 12 males participated in this study. Twenty-eight(56%) of impacted molar teeth were in the right side and 22 (44%) were in the left side. Baseline values of PD, CAL, and GI at three points of the distal surface of the mandibular second molar tooth had no significant differences with follow-up values (P-value> 0.05). According to the radiographs, baseline BH also had insignificant difference with follow-up height (P-value>0.05). Conclusion: Surgical removal of impacted mandibular third molar does not affect periodontium after 6 months