A Conceptual Framework for Understanding Illegal Killing of Large Carnivores

The growing complexity and global nature of wildlife poaching threaten the survival of many species worldwide and are outpacing conservation efforts. Here, we reviewed proximal and distal factors, both social and ecological, driving illegal killing or poaching of large carnivores at sites where it can potentially occur. Through this review, we developed a conceptual social–ecological system framework that ties together many of the factors influencing large carnivore poaching. Unlike most conservation action models, an important attribute of our framework is the integration of multiple factors related to both human motivations and animal vulnerability into feedbacks. We apply our framework to two case studies, tigers in Laos and wolverines in northern Sweden, to demonstrate its utility in disentangling some of the complex features of carnivore poaching that may have hindered effective responses to the current poaching crisis. Our framework offers a common platform to help guide future research on wildlife poaching feedbacks, which has hitherto been lacking, in order to effectively inform policy making and enforcement

A Participatory Mapping and Agent-Based Approach to Promote Coexistence Between Idaho Ranchers and Gray Wolves

This poster was presented at the 2016 Idaho EPSCoR Annual Meeting, October 19-21, in Couer d\u27Alene Idaho

Keck/LRIS Spectroscopic Confirmation of Coma Cluster Dwarf Galaxy Membership Assignments

Keck/LRIS multi-object spectroscopy has been carried out on 140 of some of the lowest and highest surface brightness faint (19 < R < 22) dwarf galaxy candidates in the core region of the Coma Cluster. These spectra are used to measure redshifts and establish membership for these faint dwarf populations. The primary goal of the low surface brightness sample is to test our ability to use morphological and surface brightness criteria to distinguish between Coma Cluster members and background galaxies using high resolution HST/ACS images. Candidates were rated as expected members, uncertain, or expected background. From 93 spectra, 51 dwarf galaxy members and 20 background galaxies are identified. Our morphological membership estimation success rate is ~100% for objects expected to be members and better than ~90% for galaxies expected to be in the background. We confirm that low surface brightness is a very good indicator of cluster membership. High surface brightness galaxies are almost always background with confusion arising only from the cases of the rare compact elliptical galaxies. The more problematic cases occur at intermediate surface brightness. Many of these galaxies are given uncertain membership ratings, and these were found to be members about half of the time. Including color information will improve membership determination but will fail for some of the same objects that are already mis-identified when using only surface brightness and morphology criteria. Compact elliptical galaxies with B-V colors ~0.2 magnitudes redward of the red sequence in particular require spectroscopic follow-up. In a sample of 47 high surface brightness, UCD candidates, 19 objects have redshifts which place them in the Coma Cluster. Redshift measurements are presented and the use of indirect means for establishing cluster membership is discussed.Comment: Accepted for publication in ApJ, 25 pages, 15 figure

How does quality enter into health care purchasing decisions?

A number of employers, business consortia, and public purchasers are promoting value-based purchasing as a way to improve the quality of patient care. Some purchasers are using publicly available information on health plan and provider performance to make their health plan and provider choices, while others are using their market power to drive improvements in patient care and safety. This article examines six key strategies used by purchasers

UCDs in the Coma Cluster

As part of the HST/ACS Coma Cluster Treasury Survey, we have undertaken a Keck/LRIS spectroscopic campaign to determine membership for faint dwarf galaxies. In the process, we discovered a population of Ultra Compact Dwarf galaxies (UCDs) in the core region of the Coma cluster. At the distance of Coma, UCDs are expected to have angular sizes 0.01 < R_e < 0.2 arcsec. With ACS imaging, we can resolve all but the smallest ones with careful fitting. Candidate UCDs were chosen based on magnitude, color, and degree of resolution. We spectroscopically confirm 27 objects as bona fide UCD members of the Coma cluster, a 60% success rate for objects targeted with M_R < -12. We attribute the high success rate in part to the high resolution of HST data and to an apparent large population of UCDs in Coma. We find that the UCDs tend to be strongly clustered around giant galaxies, at least in the core region of the cluster, and have a distribution and colors that are similar to globular clusters. These findings suggest that UCDs are not independent galaxies, but rather have a star cluster origin. This current study provides the dense environment datapoint necessary for understanding the UCD population.Comment: 6 pages, 9 figures, to appear in the conference proceedings of "A Universe of Dwarf Galaxies" (Lyon, June 14-18, 2010

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets.

RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization

Selector function of MHC I molecules is determined by protein plasticity

The selection of peptides for presentation at the surface of most nucleated cells by major histocompatibility complex class I molecules (MHC I) is crucial to the immune response in vertebrates. However, the mechanisms of the rapid selection of high affinity peptides by MHC I from amongst thousands of mostly low affinity peptides are not well understood. We developed computational systems models encoding distinct mechanistic hypotheses for two molecules, HLA-B*44:02 (B*4402) and HLA-B*44:05 (B*4405), which differ by a single residue yet lie at opposite ends of the spectrum in their intrinsic ability to select high affinity peptides. We used &lt;em&gt;in vivo&lt;/em&gt; biochemical data to infer that a conformational intermediate of MHC I is significant for peptide selection. We used molecular dynamics simulations to show that peptide selector function correlates with protein plasticity, and confirmed this experimentally by altering the plasticity of MHC I with a single point mutation, which altered &lt;em&gt;in vivo&lt;/em&gt; selector function in a predictable way. Finally, we investigated the mechanisms by which the co-factor tapasin influences MHC I plasticity. We propose that tapasin modulates MHC I plasticity by dynamically coupling the peptide binding region and {\alpha}&lt;sub&gt;3&lt;/sub&gt; domain of MHC I allosterically, resulting in enhanced peptide selector function