Investigating γ\gamma-ray halos around three HAWC bright sources in Fermi-LAT data

Numerous extended sources around Galactic pulsars have shown significant $\gamma$-ray emission from GeV to TeV energies, revealing hundreds of TeV energy electrons scattering off of the underlying photon fields through inverse Compton scattering (ICS). HAWC TeV gamma-ray observations of few-degree extended emission around the pulsars Geminga and Monogem, and LAT GeV emission around Geminga, suggest that systems older than 100 kyr have multi-TeV $e^\pm$ propagating beyond the SNR-PWN system into the interstellar medium. Following the discovery of few $\gamma$-ray sources by HAWC at energies E$>100$~TeV, we investigate the presence of an extended $\gamma$-ray emission in Fermi-LAT data around the three brightest sources detected by HAWC up to 100 TeV. We find an extended emission of $\theta_{68} = 1.00^{+0.05}_{-0.07}$ deg around eHWC J1825-134 and $\theta_{68} = 0.71\pm0.10$ deg eHWC J1907+063. The analysis with ICS templates on Fermi-LAT data point to diffusion coefficient values which are significantly lower than the average Galactic one. When studied along with HAWC data, the $\gamma$-ray Fermi-LAT data provide invaluable insight into the very high-energy electron and positron parent populations.Comment: 18 pages and 11 figures. Phys.Rev.D 104 (2021) 10, 10300

A Cross-correlation Study between IceCube Neutrino Events and the Fermi Unresolved Gamma-ray Sky

With the coincident detections of electromagnetic radiation together with gravitational waves (GW170817) or neutrinos (TXS 0506+056), the new era of multimessenger astrophysics has begun. Of particular interest are the searches for correlation between the high-energy astrophysical neutrinos detected by the IceCube Observatory and gamma-ray photons detected by the Fermi Large Area Telescope (LAT). So far, only sources detected by the LAT have been considered in correlation with IceCube neutrinos, neglecting any emission from sources too faint to be resolved individually. Here, we present the first cross-correlation analysis considering the unresolved gamma-ray background (UGRB) and IceCube events. We perform a thorough sensitivity study and, given the lack of identified correlation, we place upper limits on the fraction of the observed neutrinos that would be produced in proton-proton (p-p) or proton-gamma (p-gamma) interactions from the population of sources contributing to the UGRB emission and dominating its spatial anisotropy (aka blazars). Our analysis suggests that, under the assumption that there is no intrinsic cutoff and/or hardening of the spectrum above Fermi-LAT energies, and that all gamma-rays from the unresolved blazars dominating the UGRB fluctuation field are produced by neutral pions from p-p (p-gamma) interactions, up to 60% (30%) of such population may contribute to the total neutrino events observed by IceCube. This translates into a O(1%) maximum contribution to the astrophysical high-energy neutrino flux observed by IceCube at 100 TeV.Comment: This version is submitted to Ap

Sodium citrate supplementation: An updated revision and practical recommendations on exercise performance, hydration status, and potential risks

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Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome

The neuromuscular junction is exposed to different types of insult, including mechanical trauma, toxins and autoimmune antibodies and, accordingly, has retained through evolution a remarkable ability to regenerate. Regeneration is driven by multiple signals that are exchanged among the cellular components of the junction. These signals are largely unknown. Miller Fisher syndrome is a variant of Guillain-Barr\ue9 syndrome caused by autoimmune antibodies specific for epitopes of peripheral axon terminals. Using an animal model of Miller Fisher syndrome, we recently reported that a monoclonal anti-polysialoganglioside GQ1b antibody plus complement damages nerve terminals with production of mitochondrial hydrogen peroxide, which activates Schwann cells. Several additional signaling molecules are likely to be involved in the activation of the regeneration program in these cells. Using an in vitro cellular model consisting of co-cultured primary neurons and Schwann cells, we found that ATP is released by neurons injured by the anti-GQ1b antibody plus complement. Neuron-derived ATP acts as an alarm messenger for Schwann cells, where it induces the activation of intracellular pathways, including calcium signaling, cAMP and CREB, which, in turn, produce signals that promote nerve regeneration. These results contribute to defining the cross-talk taking place at the neuromuscular junction when it is attacked by anti-gangliosides autoantibodies plus complement, which is crucial for nerve regeneration and is also likely to be important in other peripheral neuropathies

AstroPix: Investigating the Potential of Silicon Pixel Sensors in the Future of Gamma-ray Astrophysics

This paper details preliminary photon measurements with the monolithic silicon detector ATLASPix, a pixel detector built and optimized for the CERN experiment ATLAS. The goal of this paper is to determine the promise of pixelated silicon in future space-based gamma-ray experiments. With this goal in mind, radioactive photon sources were used to determine the energy resolution and detector response of ATLASPix; these are novel measurements for ATLASPix, a detector built for a ground-based particle accelerator. As part of this project a new iteration of monolithic Si pixels, named AstroPix, have been created based on ATLASPix, and the eventual goal is to further optimize AstroPix for gamma-ray detection by constructing a prototype Compton telescope.The energy resolution of both the digital and analog output of ATLASPix is the focus of this paper, as it is a critical metric for Compton telescopes. It was found that with the analog output of the detector, the energyresolution of a single pixel was 7.69 +/- 0.13% at 5.89 keV and 7.27 +/- 1.18% at 30.1 keV, which exceeds the conservative baseline requirements of 10% resolution at 60 keV and is an encouraging start to an optimistic goal of<2% resolution at 60 keV. The digital output of the entire detector consistently yielded energy resolutions that exceeded 100% for different sources. The analog output of the monolithic silicon pixels indicates that thisis a promising technology for future gamma-ray missions, while the analysis of the digital output points to the need for a redesign of future photon-sensitive monolithic silicon pixel detectors.Comment: 12 pages, proceedings, International Society for Optics and Photonics (SPIE) Astronomical Telescopes and Instrumentation Digital Forum, Dec. 14-18 202