Fingertip reconstruction: study of functional and cosmetic results of various local flaps and grafting techniques in patients attending a tertiary care center in North India

Background: Finger injuries are becoming more common with the increasing use of mechanical, industrial, and household appliances. There are six main types of repair for this injury. The replacement of skin loss in digital injuries, particularly on the volar aspects, is an important part of hand-injury management. It would be of value to know the best type of cover, especially for sensory reinnervation as well as for subjective evaluation, cosmetic appearance and freedom from complications. The objective of this study was to measure incidence of age, sex, site, pattern of injury as well as to evaluate and compare the functional and cosmetic results of the various local flap and grafting techniques in finger reconstruction distal to metacarpophalangeal joint.Methods: In a prospective study between May 2014 to October 2018 consisting of 50 patients (43 males, 7 females), aged between 2 years and 54 years, with soft tissue loss distal to metacarpophalangeal joint were treated with either free split-thickness skin grafts, palmar flaps, cross-finger flap or pedicle flaps from the abdomen. The follow-up period ranged from 10 days to 15 months from the date of surgery. Subjective and objective evaluation was done and graded as excellent, good, fair and poor.Results: In this series there were 2 good and 6 fair results for split skin grafting; 9 good and 6 fair results for v-y plasty; 5 excellent, 12 good and 4 fair results for cross finger flap; 1 good and 1 fair result for radial artery based flap; 1 excellent and 1 good for first metacarpal artery based flap and 2 good results for abdominal flap. Overall 6(12%) had excellent, 27(54%) had good and 17(34%) had fair results. None of them had poor results.Conclusions: The group of patients with cross-finger flaps had less subjective complaints and more normal objective testing results than the other groups. When an extensive tactile pad avulsion exists, the cross-finger pedicle flap offers the best long-term result with fewer secondary problems. The exclusive use of any one method cannot be advocated since each serves an useful purpose under proper conditions

Developmental Performance Ranking of SAARC Nations: An Application of TOPSIS Method of Multi-Criteria Decision Making

To be developed, nations are trying to cope up with the fast-changing economy and technology of the world. But the development of a nation does not depend only on these two factors rather several other indicators are essential to a country’s development. The present study deals with the progress of the SAARC (South Asian Association for Regional Cooperation) countries towards development through social, economic and environmental stability. This study aims at analyzing the comparative developmental performance of the SAARC nations in accordance with the Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs). In this study, we have prioritized the 8 SAARC nations based on 4 indicators (economic, demographic, health and environment indicators) and 20 variables using the multi-criteria decision-making method (MCDM). The result showed that Sri Lanka has prioritized 1st followed by Bhutan. India has been ranked 4th and Afghanistan was least prioritized

Neonatal morbidity and care-seeking behavior in urban Lucknow

We conducted this study to assess the neonatal morbidity and care-seeking behavior amongst slum and non-slum dwellers at Lucknow. One hundred and fifty neonates were recruited within 48 hours of birth from an urban Reproductive and Child Health center and followed up at 6 weeks±15 days at home. Twenty five (16.6%) were lost to follow-up. Among those followed up, 46.4% (58/125) developed one or more morbidity; 26% (15/58) of these did not receive qualified medical care. Neonatal morbidity was 56.8% (33/ 58) among slum dwellers and 37.3% (25/67) among non-slum dwellers (absolute difference=19.5%, 95% CI=3.3 to 34.7; P=0.04). Severe neonatal illnesses were also significantly higher among neonates from slums as compared to those from non-slum areas (OR=4.50, 95%CI=1.28 to 16.38, P=0.007). Male gender was associated with any care-seeking (OR=1.24, 95% CI =1.24 to 91.99; P=0.03) and was more likely to be seen by a qualified provider (OR=3.8, 95% CI=1.05 to 13.94; P=0.04). Since nearly half of the neonates had morbidity and more than a quarter of them did not receive qualified medical care, there is a need to introduce Community Integrated Management of Neonatal and Childhood Illnesses (IMNCI) program here, emphasizing on the importance of qualified medical care for ill neonates, including females

On the Inhibition of COVID-19 Protease by Indian Herbal Plants: An In Silico Investigation

COVID-19 has quickly spread across the globe, becoming a pandemic. This disease has a variable impact in different countries depending on their cultural norms, mitigation efforts and health infrastructure. In India, a majority of people rely upon traditional Indian medicine to treat human maladies due to less-cost, easier availability and without any side-effect. These medicines are made by herbal plants. This study aims to assess the Indian herbal plants in the pursuit of potential COVID-19 inhibitors using in silico approaches. We have considered 18 extracted compounds of 11 different species of these plants. Our calculated lipophilicity, aqueous solubility and binding affinity of the extracted compounds suggest that the inhibition potentials in the order; harsingar > aloe vera > giloy > turmeric > neem > ashwagandha > red onion > tulsi > cannabis > black pepper. On comparing the binding affinity with hydroxychloroquine, we note that the inhibition potentials of the extracts of harsingar, aloe vera and giloy are very promising. Therefore, we believe that these findings will open further possibilities and accelerate the works towards finding an antidote for this malady

Extended modified cubic B-spline algorithm for nonlinear Burgers' equation

AbstractIn this paper, an extended modified cubic B-Spline differential quadrature method is proposed to approximate the solution of the nonlinear Burgers' equation. The proposed method is used in space and a five-stage and four order strong stability-preserving time-stepping Runge–Kutta (SSP-RK54) method is used in time. The accuracy and efficiency of the method is illustrated by considering four numerical problems. The numerical results of the method are compared with some existing methods and it was found that the proposed numerical method produces acceptable results and even more accurate results in comparison with some existing methods. The stability analysis of the scheme is also carried out and was found to be unconditionally stable

Developmental Performance Ranking of SAARC Nations: An Application of TOPSIS Method of Multi-Criteria Decision Making

To be developed, nations are trying to cope up with the fast-changing economy and technology of the world. But the development of a nation does not depend only on these two factors rather several other indicators are essential to a country’s development. The present study deals with the progress of the SAARC (South Asian Association for Regional Cooperation) countries towards development through social, economic and environmental stability. This study aims at analyzing the comparative developmental performance of the SAARC nations in accordance with the Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs). In this study, we have prioritized the 8 SAARC nations based on 4 indicators (economic, demographic, health and environment indicators) and 20 variables using the multi-criteria decision-making method (MCDM). The result showed that Sri Lanka has prioritized 1st followed by Bhutan. India has been ranked 4th and Afghanistan was least prioritized