Business consulting para la empresa DP World Logistics sede Callao

En un entorno volátil, incierto, complejo y ambiguo (VICA) como el actual, en el que existe incertidumbre debido a la coyuntura sanitaria, política y económica, surge la necesidad de ser eficientes en los servicios prestados por las empresas, de manera que se logre mantener y mejorar el posicionamiento en el mercado, ofreciendo propuestas de valor más atractivas a los clientes. Ante esta circunstancia, se plantea un proyecto de mejora mediante un business consulting de la empresa DP World Logistics. Se utilizó la herramienta de diagnóstico empresarial para identificar los principales problemas y sus causas; se ponderó el impacto de cada uno, con lo cual se plantearon alternativas de solución y se determinó el enfoque en el rediseño de proceso del servicio de desconsolidación de mercancía de importación. El proyecto se enfoca en el aumento de la eficiencia operativa de los procesos de recepción y de despacho de mercancías de importación. Para ello, se estableció una metodología en donde (a) se realice un alineamiento de los objetivos del proyecto con la estrategia competitiva de la empresa, (b) se realice una autoevaluación del proceso actual y de sus resultados, (c) se planifique las actividades y recursos, (d) se analice y rediseño del proceso, (e) se implemente los cambios sugeridos y (f) se evalúe los resultados operativos y financieros del proyecto. Los resultados esperados de la implementación del rediseño de procesos se centran en la reducción del tiempo operativo de recepción y de despacho en un 15%. Ello se logrará de manera progresiva, a través de la simplificación de procesos y el monitoreo diario de las actividades; logrando de ese modo la prestación de un servicio con tiempo competitivo, con cero errores y un alto nivel de fidelización del cliente. Con respecto a la recuperación de la inversión, se ha elaborado un análisis económico-financiero en base a la data histórica y proyectada, considerando que el ratio beneficio-costo es 44.98, es decir, por US$1 dólar invertido, se ha obtenido una ganancia de US$ 43.98, y la recuperación de la inversión es de un mes y 18 días, en el escenario moderado.In a volatility, uncertain, complex and ambitious (VUCA) environment like the current one, in which there is uncertainty due to the health, political and economic situation, the need arises to be efficient in the services provided by companies, so that it is possible to keep and improve the positioning of a company, offering more attractive value propositions to customers. Under this circumstance, an improvement project is proposed through a business consulting of the DP World Logistics company. The business diagnostic tool was used to identify the main problems and their causes; the impact of each one was weighed, with which solution alternatives were proposed and the focus was determined on the redesign of the process of the import merchandise deconsolidation service. The project focuses on increasing the operational efficiency of the import merchandise reception and dispatch processes. To achieve that, a methodology was established where (a) the project objectives are aligned with the company's competitive strategy, (b) a self- evaluation of the current process and its results is carried out, (c) the activities and resources, (d) the process is analyzed and redesigned, (e) the suggested changes are implemented and (f) the operational and financial results of the project are evaluated. The expected results of the implementation of the redesign of processes are focused on reducing the operational time of reception and dispatch time by 15%. This will be achieved progressively, through the simplification of processes and the daily monitoring of activities; therefore, achieving the provision of a service with competitive time, with zero errors and a high level of customer loyalty. Regarding to the recovery of the investment, an economic- financial analysis has been prepared based on the historical and projected data, considering that the benefit-cost ratio is 44.98, that is, for US $1 dollar invested, a profit of US$ 43.98 and the recovery of the investment is one month and 18 days, in the moderate scenario

Separating T Cell Targeting Components onto Magnetically Clustered Nanoparticles Boosts Activation

T cell activation requires the coordination of a variety of signaling molecules including T cell receptor-specific signals and costimulatory signals. Altering the composition and distribution of costimulatory molecules during stimulation greatly affects T cell functionality for applications such as adoptive cell therapy (ACT), but the large diversity in these molecules complicates these studies. Here, we develop and validate a reductionist T cell activation platform that enables streamlined customization of stimulatory conditions. This platform is useful for the optimization of ACT protocols as well as the more general study of immune T cell activation. Rather than decorating particles with both signal 1 antigen and signal 2 costimulus, we use distinct, monospecific, paramagnetic nanoparticles, which are then clustered on the cell surface by a magnetic field. This allows for rapid synthesis and characterization of a small number of single-signal nanoparticles which can be systematically combined to explore and optimize T cell activation. By increasing cognate T cell enrichment and incorporating additional costimulatory molecules using this platform, we find significantly higher frequencies and numbers of cognate T cells stimulated from an endogenous population. The magnetic field-induced association of separate particles thus provides a tool for optimizing T cell activation for adoptive immunotherapy and other immunological studies