Prevalence of <i>C.trachomatis</i> infection^* in children aged 1 to 9 years by village.

<p>*<i>C. trachomatis</i> infection detected by Amplicor.</p>†<p>Village 12 withdrew after 17 months.</p

The prevalence of <i>Chlamydia trachomatis</i> infection* in children aged 1 to 9 years for the 14 villages^†.

<p>Individual villages are represented by the grey lines. Several villages overlie each other with a prevalence of 0%. The overall village level average is represented by the black line. *<i>Chlamydia trachomatis</i> infection determined by Amplicor CT PCR assay. ^†Village No. 12 withdrew after 17-months.</p

Follow-up rates for children aged 1 to 9 years at each time point, by village.

<p>*Village 12 withdrew after 17 months.</p

<i>Chlamydia trachomatis</i> infection load.

<p>*The individual infection load is the geometric mean and 95% CI of the <i>C. trachomatis</i> infection load expressed in copies of <i>ompA</i>/swab, for all infected individuals in the study population.</p>†<p>The community load of infection is the Williams Mean for the study population (including uninfected individuals), expressed in copies of the <i>ompA</i>/swab.</p

The prevalence of TF in children aged 1 to 9 years for the 14 villages*.

<p>Individual villages are represented by the grey lines. Several villages overlie each other with a prevalence of 0%. The overall village level average is represented by the black line. The dashed line represents the WHO TF_%1–9 treatment initiation threshold level of 10%. *Village No. 12 withdrew after 17-months. TF = Trachomatous Inflammation, Follicular.</p

Baseline village populations and antibiotic treatment coverage.

<p>Baseline village populations and antibiotic treatment coverage.</p

Normalized optical density (in an ELISA for anti-Pgp3 antibody) in sera from 1–9-year-old children who were positive (red spots in panel (a)) and negative (blue spots in panel (a)) for conjunctival <i>Chlamydia trachomatis</i> infection by droplet digital PCR, Kiritimati Island, Kiribati, November 2015.

<p>In panel (a), the threshold for anti-Pgp3 seropositivity, derived using a finite mixture model, is indicated (dotted line), and within each one-year age band, spots have been moved horizontally in order to separate data points that would otherwise have been superimposed. In panel (b), red lines represent the median values, grey boxes represent inter-quartile ranges, whiskers represent the minima and maxima.</p

Age-specific prevalence of anti-Pgp3 antibodies in 1–9-year-old children, Kiritimati Island, Kiribati, November 2015.

<p>Grey columns indicate the seroprevalence estimate for each one-year age band; red lines indicate 95% confidence intervals around those estimates.</p

Load of <i>Chlamydia trachomatis</i> infection in 1–9-year-old children with and without active trachoma in either eye, Kiritimati Island, Kiribati, November 2015.

<p>Red lines represent the median value, grey boxes represent inter-quartile ranges and whiskers represent the minima and maxima. TF = trachomatous inflammation—follicular; TI = trachomatous inflammation—intense.</p

Normalized optical density (in an ELISA for anti-Pgp3 antibody) in sera from 1–9-year-old children with and without active trachoma in either eye, Kiritimati Island, Kiribati, November 2015.

<p>Red lines represent the median value, grey boxes represent inter-quartile range and whiskers represent the minima and maxima.</p