754 research outputs found

    Precontact utilization of sandhill environments during the Pelican Lake and Besant phases

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    Construction of a natural gas pipeline through central Saskatchewan resulted in three years of investigation at two archaeological sites within the Douglas Park Sandhills near Elbow, Saskatchewan. Excavation, testing, and monitoring resulted in the recovery of an array of cultural materials from sites EgNn 9 and EgNo 23. Typical precontact period campsite activities and the communal hunting of bison are indicated by the cultural materials recovered. Diagnostic projectile points collected from sites EgNn 9 and EgNo 23 date occupation of the region to the Middle and Late Precontact Periods. Controlled excavation of the sites resulted in the identification of a series of intact buried occupations dating to the Pelican Lake and Besant phases. Sites EgNn 9 and EgNo 23 provide valuable insight into precontact utilization of sandhill environments within the greater grasslands ecosystem of the Great Plains. This thesis includes an overview of precontact utilization of sandhill environments across the Great Plains and a view into the subsistence and settlement choices made by precontact populations within the region. The archaeological record of the Great Plains indicates that precontact populations developed a stable, broad spectrum hunter-gatherer adaptation to the region following glacial retreat and the opening of the vast grasslands. Integration of the resources available from the 'ecological islands' created by sandhill ecosystems appears to have begun in the Early Precontact Period and continued through to the Historic Period. The focus of this thesis is the Pelican Lake and Besant phases which are represented at sites EgNn 9 and EgNo 23, and have been identified at the full range of archaeological sites identified within the Great Plains region. An overview of the Pelican Lake and Besant phases across the northern Great Plains is also included in this thesis

    Integrating Sustainability in Asian Business Schools

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    This chapter discusses the ProSPER.Net initiative to integrate sustainability into business schools in the Asia-Pacific region. The project deserves scrutiny, as it led to positive change within each of the partner universities, involving innovative research, curricular transformation and the development of regional case studies. As such, the project is an instructive case in its own right, highlighting the successes, as well as the obstacles encountered, in introducing and coordinating education for sustainable development (ESD) in diverse organizations. The experience of the project clearly shows that whereas there is a recognized need to promote ESD in business schools throughout Asia, the process of achieving this is difficult and complex. Through a consideration of the achievements and frustrations of the project, it is hoped that this chapter will contribute to a better understanding of these issues, and will help in subsequent efforts to integrate sustainability in business education

    Avoiding Overtreatment at the End of Life: Physician-Patient Communication and Truly Informed Consent

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    This paper’s primary focus will be on considering how best to ensure that patients have the tools to make both informed and authentic choices about their care at the end of life. We will argue that truly informed decision making can help to reduce excessive end-of-life care by any measure. Most importantly for dying patients, better informed decisions can help reduce unnecessary suffering and result in care that aligns with their well-considered values and preferences. In the first part of this paper, we will explain that, by any of these measures, many dying patients are receiving too much therapy and life-prolonging care. We will also briefly discuss the many factors that contribute to this state of affairs: the culture of denial of death, physicians’ professional culture and attitudes toward treatment, physicians’ fear of liability, physician avoidance of discussions about prognosis, and the impact of payment incentives that encourage overutilization of medical technologies. In the second part of this paper, we will explain that, under the doctrine of informed consent, physicians have an ethical and legal obligation to provide patients with timely and accurate information that will enable patients to make informed decisions about end-of-life care. Yet compliance with informed consent law does not ensure that patients’ decisions are truly informed and, in practice, the norm is still to provide too much care. In the third part of the paper, we discuss several tools and techniques that are available to help physicians and patients achieve the goal of truly informed decision making, including training to promote the practice of shared decision making and the use of decision aids

    Equal Care, Unequal Outcomes: Experiences of a REACH 2010 Community

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    Diabetes is growing in prevalence and costs. Guidelines for care have been available since 1983, yet diabetes care and outcomes remain less than ideal. CDC’s Racial and Ethnic Approaches to Community Health 2010 (REACH 2010) identified diabetes in African Americans as a priority for action. This article documents the activities, interventions, and current progress of the REACH 2010 diabetes coalition formed in Charleston and Georgetown counties, South Carolina, in reducing health care disparities and describes next steps for improving outcomes. The Chronic Care Model guided many of the implementation activities, and chart audits were used to document outcomes. Ambulatory care visits (N = 1522) between 2000 and 2004 were reviewed. Significant progress has been made in reducing disparities in process measures, but similar reductions for intermediate outcomes have not been observed

    Task network models in the prediction of workload imposed by extravehicular activities during the Hubble Space Telescope servicing mission

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    In a joint effort with Brooks AFB, Texas, the Flight Crew Support Division at JSC has begun a computer simulation and performance modeling program directed at establishing the predictive validity of software tools for modeling human performance during spaceflight. This paper addresses the utility of task network modeling for predicting the workload that astronauts are likely to encounter in extravehicular activities (EVA) during the Hubble Space Telescope (HST) repair mission. The intent of the study was to determine whether two EVA crewmembers and one intravehicular activity (IVA) crewmember could reasonably be expected to complete HST Wide Field/Planetary Camera (WFPC) replacement in the allotted time. Ultimately, examination of the points during HST servicing that may result in excessive workload will lead to recommendations to the HST Flight Systems and Servicing Project concerning (1) expectation of degraded performance, (2) the need to change task allocation across crewmembers, (3) the need to expand the timeline, and (4) the need to increase the number of EVA's

    Letter to the Editor

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    Acetylcholinesterase inhibition dose–response modeling for chlorpyrifos and chlorpyrifos-oxon

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    AbstractThis paper evaluates new data for cholinesterase inhibition with chlorpyrifos (CPF). Marty et al. (2012) recently conducted a CPF cholinesterase inhibition study in rats that included testing of males and females, dosing by gavage or diet, administration in corn oil or milk, and with pups and adults. Additionally, the study included cholinesterase inhibition testing for CPF-oxon, the active moiety that inhibits cholinesterase. The study included 5–6 dose groups with eight animals/sex/group for most of the tests. This paper provides a benchmark dose (BMD) analysis of the data from Marty et al. (2012), including a BMD meta-analysis that includes CPF cholinesterase inhibition data from different assays within the Marty et al. (2012) study and, in one case, from another study. From the meta-analysis, the recommended BMD10s, based on brain acetylcholinesterase inhibition, are 1.7mg/kg/day (BMDL10=1.3mg/kg/day) for acute doses to children and adults, and 0.67mg/kg/day (BMDL10=0.53mg/kg/day) for repeat doses to children and adults. At the dose levels considered in this analysis, there was no evidence of a difference in responses between males and females, corn oil versus milk administration, or pups versus adults. The data on pups versus adults show that an extra safety factor to protect the young is not needed for CPF. CPF data from the literature suggest that brain cholinesterase inhibition is the most appropriate metric for cholinesterase inhibition risk assessment

    Dissociations within nondeclarative memory in Huntington's disease.

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