Cultural heritage and sustainable development targets : a possible harmonisation? Insights from the European Perspective

The Agenda 2030 includes a set of targets that need to be achieved by 2030. Although none of the 17 Sustainable Development Goals (SDGs) focuses exclusively on cultural heritage, the resulting Agenda includes explicit reference to heritage in SDG 11.4 and indirect reference to other Goals. Achievement of international targets shall happen at local and national level, and therefore, it is crucial to understand how interventions on local heritage are monitored nationally, therefore feeding into the sustainable development framework. This paper is focused on gauging the implementation of the Sustainable Development Goals with reference to cultural heritage, by interrogating the current way of classifying it (and consequently monitoring). In fact, there is no common dataset associated with monitoring SDGs, and the field of heritage is extremely complex and diversified. The purpose for the paper is to understand if the taxonomy used by different national databases allows consistency in the classification and valuing of the different assets categories. The European case study has been chosen as field of investigation, in order to pilot a methodology that can be expanded in further research. A cross‐comparison of a selected sample of publicly accessible national cultural heritage databases has been conducted. As a result, this study confirms the existence of general harmonisation of data towards the achievement of the SDGs with a broad agreement of the conceptualisation of cultural heritage with international frameworks, thus confirming that consistency exists in the classification and valuing of the different assets categories. However, diverse challenges of achieving a consistent and coherent approach to integrating culture in sustainability remains problematic. The findings allow concluding that it could be possible to mainstream across different databases those indicators, which could lead to depicting the overall level of attainment of the Agenda 2030 targets on heritage. However, more research is needed in developing a robust correlation between national datasets and international targets

Effects of fire frequency and seasonality on the population dynamics of the critically endangered Clanwilliam cedar

The Clanwilliam cedar, (Widdringtonia wallichii, formerly W. cedarbergensis) is a threatened conifer endemic to the fire-adapted fynbos vegetation of the Cederberg mountains, South Africa. Here its population size has drastically declined, and its conservation status subsequently escalated to critically endangered in 2013 by IUCN Red List of Plants. Studies have hypothesised that excessive exploitation for timber products, climate change and unfavourable fire regimes (frequency, intensity and season) have contributed to this species’ decline. This decline led to the overarching aim of the study to gain a better understanding of the effects of fire frequency and seasonality on the life history of Clanwilliam cedar. To characterise fire patterns in the Cederberg Wilderness Area, I used a latent class analysis on fire indices calculated from a fire history database. To explore the effects of fire seasonality on the cedar count numbers I used a negative binomial hurdle model using seasonal fire indices and environmental data. To examine the impact of fire frequency and seasonality on the life-history of the Clanwilliam cedar, I used a stochastic demographic model based on parameter values obtained from the literature. Findings from the latent class model indicated that the main axes of variation in fire frequency were the fire indices representing total fire frequency, summer fires, autumn fires in the last 30 years and fires in the last 30 years. Although these fire indices were able to distinguish relatively well between the three latent classes, it however was difficult to disentangle the relative importance of each fire index due to their strong covariation. This points to a more general pattern, suggesting that it is necessary to examine the entire fire frequency history and the seasonality pattern in order to understand the current state of the population of the Clanwilliam cedar. The linear count model revealed autumn fires as being positively associated, whereas mean annual precipitation and mean annual temperature and precipitation seasonality were negatively associated with the cedar numbers. The stochastic demographic model showed both summer and winter fires induce positive growth rates at firereturn intervals greater than 10 years, but winter fires always permitted a higher population growth rate. The sensitivity analysis of the stochastic population growth rate (log λs) to changes in the life-history parameters at fire-return intervals of 10 and 20 years showed that fire mortality was most important for a summer fire regime, and growth rates of adult trees were most important for a winter fire regime. The different methods used in this study provided different but complementary results, and thus insights from these various models could potentially contribute to the development of fire management strategies that reflect the complexities of fire frequency and seasonality on the population dynamics and thus persistence of the Clanwilliam cedar

1995 fisheries statistics, Lake Kariba - Zimbabwe shore

The report provides catch records for the Kapenta and inshore fisheries in the Zimbabwean waters of Lake Kariba for the year 1995. Kapenta usually constitute about 90% of the total catch from Lake Kariba; for statistical purposes catches are recorded for the 5 hydrological basins - Mlibizi, Binga, Sengwa, Bumi and Kariba. Whereas kapenta represent a unit stock which is harvested by both Zimbabwe and Zambia, the artisanal fishery exploits inshore species which generally occupy water less than 10m deep along the shoreline, considered to be 2 separate stocks. The main species in the inshore fishery are Oreochromis mortimeri, Sargochromis codringtonii, Tilapia rendalli, Labeo altivelis, Hydrocynus vittatus, Mormyrus longirostris, Clarias gariepinus and Synodontis zambezensis

The extent of and factors associated with self-reported overdose and self-reported receipt of naloxone among people who inject drugs (PWID) in England, Wales and Northern Ireland.

BACKGROUND: Overdose is a major cause of death among PWID, and for opioid overdoses naloxone administration can reduce harm. However, globally there is limited national level data on the extent of non-fatal overdose and naloxone uptake. The first national level data on the extent of self-reported overdose and self-reported receipt of naloxone among UK PWID, providing a baseline to monitor the impact of the recent policy change regarding naloxone availability, is presented. METHODS: Data on self-reported overdose and receipt of naloxone during the preceding year for 2013-2014 from a national survey of PWID was analysed. Participants who reported injecting during the preceding year were included. RESULTS: Participants (3850) were predominantly male (75%); mean age was 36 years. The most commonly injected drugs were: heroin (91%), crack (45%) and amphetamine (29%). 15% (591) reported overdosing during the preceding year. There were no differences in the proportion reporting overdose by age or gender, but overdose was more common among those who: injected multiple drugs; recently ceased addiction treatment; injected with used needles/syringes; ever had transactional sex; had used a sexual health clinic or emergency department and lived in Wales or Northern Ireland. Among those reporting an overdose during the preceding year, a third reported two to four overdoses and 7.5% five or more overdoses; half reported receiving naloxone. Those reporting naloxone receipt in the preceding year were more likely to: live in Wales or Northern Ireland; ever received used needles/syringes; ever been imprisoned; and less likely to have injected two drug types. CONCLUSION: These data provide a baseline for monitoring the impact of the 2015 UK policy change to improve take-home naloxone access. Interventions tackling overdose should promote naloxone awareness and access, and target those who; are poly-drug injectors, have ceased treatment, share needles/syringes and whose drug use links to sexual activity

"It went through the roof": an observation study exploring the rise in PrEP uptake among Zimbabwean female sex workers in response to adaptations during Covid-19

INTRODUCTION: Sisters with a Voice (Sisters), a programme providing community-led differentiated HIV prevention and treatment services, including condoms, HIV testing, pre-exposure prophylaxis (PrEP) and antiretroviral therapy linkage for sex workers, reached over 26,000 female sex workers (FSW) across Zimbabwe in 2020. Zimbabwe's initial Covid "lockdown" in March 2020 and associated movement restrictions interrupted clinical service provision for 6 weeks, particularly in mobile clinics, triggering the adaptation of services for the Covid-19 context and a scale up of differentiated service delivery (DSD) models. PrEP service delivery decentralized with shifts from clinical settings towards community/home-based, peer-led PrEP services to expand and maintain access. We hypothesize that peer-led community-based provision of PrEP services influenced both demand and supply-side determinants of PrEP uptake. We observed the effect of these adaptations on PrEP uptake among FSW accessing services in Sisters in 2020. METHODS: New FSW PrEP initiations throughout 2020 were tracked by analysing routine Sisters programme data and comparing it with national PrEP initiation data for 2020. We mapped PrEP uptake among all negative FSW attending services in Sisters alongside Covid-19 adaptations and shifts in the operating environment throughout 2020: prior to lockdown (January-March 2020), during severe restrictions (April-June 2020), subsequent easing (July-September 2020) and during drug stockouts that followed (October-December 2020). RESULTS AND DISCUSSION: PrEP uptake in 2020 occurred at rates <25% (315 initiations or fewer) per month prior to the emergence of Covid-19. In response to Covid-19 restrictions, DSD models were scaled up in April 2020, including peer demand creation, community-based delivery, multi-month dispensing and the use of virtual platforms for appointment scheduling and post-PrEP initiation support. Beginning May 2020, PrEP uptake increased monthly, peaking at an initiation rate of 51% (n = 1360) in September 2020. Unexpected rise in demand coincided with national commodity shortages between October and December 2020, resulting in restriction of new initiations with sites prioritizing refills. CONCLUSIONS: Despite the impact of Covid-19 on the Sisters Programme and FSW mobility, DSD adaptations led to a large increase in PrEP initiations compared to pre-Covid levels demonstrating that a peer-led, community-based PrEP service delivery model is effective and can be adopted for long-term use

Free Radical Scavenging Activity: Antiproliferative and Proteomics Analyses of the Differential Expression of Apoptotic Proteins in MCF-7 Cells Treated with Acetone Leaf Extract of Diospyros lycioides

Breast cancer is the most common cancer in South Africa. The acetone leaf extract of Diospyros lycioides was evaluated qualitatively and quantitatively for its antioxidant potential using DPPH assay and nitric oxide radical scavenging effect, while the viability of MCF-7 cells was evaluated using the MTT. MCF-7 treated cells were stained with Hoechst 335258 dye and annexin-V-FITC to be evaluated for apoptotic effect of the extract, while mRNA expression levels of apoptotic genes were assessed by quantitative real-time PCR and deferential protein expression levels using 2D gel electrophoresis and mass spectrometry. Results revealed presence of antioxidant constituents in the extract. Extract was shown to be cytotoxic in a concentration- and time-dependent manner. Cytotoxicity was demonstrated to be due to apoptosis, with 70% of the extract-treated cells being annexin-V-positive/PI negative at 48 hours. The extract was also shown to upregulate the expression of p53 gene with concomitant downregulation of the Bcl-2 antiapoptotic gene while differentially expressed proteins were identified as enolase, pyruvate kinase, and glyceraldehyde-3-phosphate. The extract in this study was shown to induce apoptosis at an early stage which makes it an ideal source that can be explored for compounds that may be used in the treatment and management of cancer

The Segmented Zambezi Sedimentary System from Source to Sink: 1. Sand Petrology and Heavy Minerals

The Zambezi River rises at the center of southern Africa, flows across the low-relief Kalahari Plateau, meets Karoo basalt, plunges into Victoria Falls, follows along Karoo rifts, and pierces through Precambrian basement to eventually deliver its load onto the Mozambican passive margin. Reflecting its polyphase evolution, the river is subdivided into segments with different geological and geomorphological character, a subdivision finally fixed by man’s construction of large reservoirs and faithfully testified by sharp changes in sediment composition. Pure quartzose sand recycled from Kalahari desert dunes in the uppermost tract is next progressively enriched in basaltic rock fragments and clinopyroxene. Sediment load is renewed first downstream of Lake Kariba and next downstream of Lake Cahora Bassa, documenting a stepwise decrease in quartz and durable heavy minerals. Composition becomes quartzo-feldspathic in the lower tract, where most sediment is supplied by high-grade basements rejuvenated by the southward propagation of the East African rift. Feldspar abundance in Lower Zambezi sand has no equivalent among big rivers on Earth and far exceeds that in sediments of the northern delta, shelf, and slope, revealing that provenance signals from the upper reaches have ceased to be transmitted across the routing system after closure of the big dams. This high-resolution petrologic study of Zambezi sand allows us to critically reconsider several dogmas, such as the supposed increase of mineralogical “maturity” during long-distance fluvial transport, and forges a key to unlock the rich information stored in sedimentary archives, with the ultimate goal to accurately reconstruct the evolution of this mighty river flowing across changing African landscapes since the late Mesozoic