Devil’s Claw – a natural substitute for diclofenac?

No Abstract

Assessment of occupational exposure to airborne particulates otherwise not classifiable at an iron and steel industry in Zimbabwe

No Abstrac

HIV transmission in part of the US prison system: implications for Europe.

A study in the United States has shown that HIV transmission has been occurring within the prison system in the state of Georgia.</jats:p

Vegetation Changes in the Miombo Woodlands in Northwestern Zimbabwe: A Case Study of Nkayi District 1990 to 2017

The research applied Geographic Information Systems (GISs) and remote sensing tools in quantifying land cover changes in Nkayi District and assess the drivers for such changes. This was done to link the impacts of anthropogenic activities to change in the physical environment especially looking at ecosystem goods and services, which in turn reduce their productivity. Satellite images were analyzed for 1990, 2000, 2010, and 2017 in order to produce temporal land cover maps for Nkayi District and use them as tools for estimating the rates and the extent to which land cover has changed from 1990 to 2017. Four main land cover types were identified, namely woodland, deforested land, cultivated land, and water bodies. In 1990, woodland covered 58% of the total land area in Nkayi District, while deforested land, cultivated land, and water bodies covered 31, 11, and 0.2%, respectively. From 1990 to 2017, woodland declined to 47% in 2017, while deforested land and cultivated land increased to 14.9 and 36%, respectively. The major drivers of land cover changes were increase in household numbers, which were associated with woodland clearing for agriculture. The other drivers of land cover changes were soil infertility and overgrazing by livestock. The research was crucial in detecting the problems of forage shortages and poor rangeland conditions, mainly caused by expanding fields coupled with infertile Kalahari sands. The research highlighted the urgent need to manage the fragile miombo woodlands, which are being threatened by the increased demand for land for human settlements and cultivation. Alternatively, the research also highlights the need for farmers to produce more biomass in their fields in the form of high-value crop residues to cater for the loss of rangelands

Gemeenregtelike en statutere regte van residensiele huurders gedurende die inperking in Suid-Afrika

Die COVID-19-pandemie het regoor die wereld ekonomiese verwoesting gesaai. In baie stede staar residensiele huurders, wat hulle werke as gevolg van die ekonomiese slagting verloor het, haweloosheid in die gesig. Sodanige huurders ervaar finansi61e nood en 'n gevolglike onvermo6 om huur te betaal. Hierdie toedrag van sake het die Suid-Afrikaanse regering genoop om 'n moratorium op uitsettings te plaas deur regulasies ingevolge die Wet op Rampbestuurs 57 van 2002 (die "Grendelstaatregulasies") uit te vaardig. Sodanige regulasies beperk egter vryheid van beweging en maak dit vir sommige residensiele huurders onmoontlik om voordeel uit die okkupasie van huurpersele te trek, aangesien hulle in ander provinsies of selfs oorsee vasgekeer is of was. Die eerste deel van hierdie artikel ondersoek die gemeenregtelike regte van residensiele huurders wat weens die reisbeperkinge wat deur die Grendelstaatregulasies opgele is, nie die volle genot van gehuurde eiendomme in stede kan (of kon) geniet nie. Dit analiseer die pandemie as 'n skielike, onvoorsiene en onvermydelike natnurlike gebeurtenis wat aan die elemente van die definisie van vis major voldoen. Met did doel voor o6, bespreek hierdie bydrae die reg van residensiele huurders om ingevolge die gemenereg die verweer van vis major te gebruik om kwytskelding of vermindering van huur te eis. Die tweede deel van die artikel ondersoek die beskerming van residensiele huurders teen swak behandeling deur verhuurders en teen uitsettings tydens die grendelstaat.The National Research Foundation.http://www.lexisnexis.co.zaam2022Mercantile La

Spatial mapping of hepatitis C prevalence in recent injecting drug users in contact with services.

In developed countries the majority of hepatitis C virus (HCV) infections occur in injecting drug users (IDUs) with prevalence in IDUs often high, but with wide geographical differences within countries. Estimates of local prevalence are needed for planning services for IDUs, but it is not practical to conduct HCV seroprevalence surveys in all areas. In this study survey data from IDUs attending specialist services were collected in 52/149 sites in England between 2006 and 2008. Spatially correlated random-effects models were used to estimate HCV prevalence for all sites, using auxiliary data to aid prediction. Estimates ranged from 14% to 82%, with larger cities, London and the North West having the highest HCV prevalence. The methods used generated robust estimates for each area, with a well-identified spatial pattern that improved predictions. Such models may be of use in other areas of study where surveillance data are sparse

The extent of and factors associated with self-reported overdose and self-reported receipt of naloxone among people who inject drugs (PWID) in England, Wales and Northern Ireland.

BACKGROUND: Overdose is a major cause of death among PWID, and for opioid overdoses naloxone administration can reduce harm. However, globally there is limited national level data on the extent of non-fatal overdose and naloxone uptake. The first national level data on the extent of self-reported overdose and self-reported receipt of naloxone among UK PWID, providing a baseline to monitor the impact of the recent policy change regarding naloxone availability, is presented. METHODS: Data on self-reported overdose and receipt of naloxone during the preceding year for 2013-2014 from a national survey of PWID was analysed. Participants who reported injecting during the preceding year were included. RESULTS: Participants (3850) were predominantly male (75%); mean age was 36 years. The most commonly injected drugs were: heroin (91%), crack (45%) and amphetamine (29%). 15% (591) reported overdosing during the preceding year. There were no differences in the proportion reporting overdose by age or gender, but overdose was more common among those who: injected multiple drugs; recently ceased addiction treatment; injected with used needles/syringes; ever had transactional sex; had used a sexual health clinic or emergency department and lived in Wales or Northern Ireland. Among those reporting an overdose during the preceding year, a third reported two to four overdoses and 7.5% five or more overdoses; half reported receiving naloxone. Those reporting naloxone receipt in the preceding year were more likely to: live in Wales or Northern Ireland; ever received used needles/syringes; ever been imprisoned; and less likely to have injected two drug types. CONCLUSION: These data provide a baseline for monitoring the impact of the 2015 UK policy change to improve take-home naloxone access. Interventions tackling overdose should promote naloxone awareness and access, and target those who; are poly-drug injectors, have ceased treatment, share needles/syringes and whose drug use links to sexual activity

Antimicrobial Activity, Phenolic Content, and Cytotoxicity of Medicinal Plant Extracts Used for Treating Dermatological Diseases and Wound Healing in KwaZulu-Natal, South Africa

Medicinal plants used for wound healing and skin diseases are the key to unlocking the doors to combating problematic skin diseases as resistance of pathogens to pharmaceuticals and allopathic management continues to increase. The study aimed at investigating the antimicrobial efficacies, phenolic content and cytotoxicity effects of eleven medicinal plant extracts commonly used for treating skin conditions and wound healing in traditional medicine within KwaZulu-Natal. Eleven plant species were separated into different plant parts (bulbs, roots, leaves) and extracted with different solvents. The extracts were assessed for antimicrobial activity against six Gram-positive and seven Gram-negative bacterial strains and four fungi commonly associated with skin conditions using disc diffusion and microdilution techniques. The aqueous methanolic extracts were screened for phenolic content while cytotoxicity tests were performed on all extracts using the brine shrimp lethality and tetrazolium–based colorimetric (MTT) assays. Extracts from Aloe ferox, A. arborescens and Hypericum aethiopicum were the most active against almost all of the tested bacterial and fungal strains. All plant species exhibited some degree of antimicrobial activity. Total phenolic levels, flavonoids and tannins were also higher for A. ferox, followed by A. arborescens and H. aethiopicum respectively. The cytotoxicity results of all plant extracts were in the range of 90-100% survival after 24 h in the Brine shrimp assay. Extracts considered lethal would demonstrate > 50% shrimp death. The MTT cytotoxicity test yielded LC50 values of > 1 mg/mL on all extracts indicating that they are not cytotoxic. The observed antimicrobial efficacy demonstrated by some plant species and the general lack of cytotoxic effects on all the tested extracts presents some promising and beneficial aspects of these medicinal plant extracts in the treatment of skin diseases and wound healing. The two Aloe species and H. aethiopicum were among the best extracts that exhibited consistently good antimicrobial activity and warrants further investigations and possible isolation of bioactive principles

"It went through the roof": an observation study exploring the rise in PrEP uptake among Zimbabwean female sex workers in response to adaptations during Covid-19

INTRODUCTION: Sisters with a Voice (Sisters), a programme providing community-led differentiated HIV prevention and treatment services, including condoms, HIV testing, pre-exposure prophylaxis (PrEP) and antiretroviral therapy linkage for sex workers, reached over 26,000 female sex workers (FSW) across Zimbabwe in 2020. Zimbabwe's initial Covid "lockdown" in March 2020 and associated movement restrictions interrupted clinical service provision for 6 weeks, particularly in mobile clinics, triggering the adaptation of services for the Covid-19 context and a scale up of differentiated service delivery (DSD) models. PrEP service delivery decentralized with shifts from clinical settings towards community/home-based, peer-led PrEP services to expand and maintain access. We hypothesize that peer-led community-based provision of PrEP services influenced both demand and supply-side determinants of PrEP uptake. We observed the effect of these adaptations on PrEP uptake among FSW accessing services in Sisters in 2020. METHODS: New FSW PrEP initiations throughout 2020 were tracked by analysing routine Sisters programme data and comparing it with national PrEP initiation data for 2020. We mapped PrEP uptake among all negative FSW attending services in Sisters alongside Covid-19 adaptations and shifts in the operating environment throughout 2020: prior to lockdown (January-March 2020), during severe restrictions (April-June 2020), subsequent easing (July-September 2020) and during drug stockouts that followed (October-December 2020). RESULTS AND DISCUSSION: PrEP uptake in 2020 occurred at rates <25% (315 initiations or fewer) per month prior to the emergence of Covid-19. In response to Covid-19 restrictions, DSD models were scaled up in April 2020, including peer demand creation, community-based delivery, multi-month dispensing and the use of virtual platforms for appointment scheduling and post-PrEP initiation support. Beginning May 2020, PrEP uptake increased monthly, peaking at an initiation rate of 51% (n = 1360) in September 2020. Unexpected rise in demand coincided with national commodity shortages between October and December 2020, resulting in restriction of new initiations with sites prioritizing refills. CONCLUSIONS: Despite the impact of Covid-19 on the Sisters Programme and FSW mobility, DSD adaptations led to a large increase in PrEP initiations compared to pre-Covid levels demonstrating that a peer-led, community-based PrEP service delivery model is effective and can be adopted for long-term use