Recirculating 1-K-Pot for Pulse-Tube Cryostats

A paper describes a 1-K-pot that works with a commercial pulse tube cooler for astrophysics instrumentation testbeds that require temperatures <1.7 K. Pumped liquid helium-4 cryostats were commonly used to achieve this temperature. However, liquid helium-4 cryostats are being replaced with cryostats using pulse tube coolers. The closed-cycle 1K-pot system for the pulse tube cooler requires a heat exchanger on the pulse tube, a flow restriction, pump-out line, and pump system that recirculates helium-4. The heat exchanger precools and liquefies helium- 4 gas at the 2.5 to 3.5 K pulse tube cold head. This closed-cycle 1-K-pot system was designed to work with commercially available laboratory pulse tube coolers. It was built using common laboratory equipment such as stainless steel tubing and a mechanical pump. The system is self-contained and requires only common wall power to operate. The lift of 15 mW at 1.1 K and base temperature of 0.97 K are provided continuously. The system can be scaled to higher heat lifts of .30 to 50 mW if desired. Ground-based telescopes could use this innovation to improve the efficiency of existing cry

Robust Tensioned Kevlar Suspension Design

One common but challenging problem in cryogenic engineering is to produce a mount that has excellent thermal isolation but is also rigid. Such mounts can be achieved by suspending the load from a network of fibers or strings held in tension. Kevlar fibers are often used for this purpose owing to their high strength and low thermal conductivity. A suite of compact design elements has been developed to improve the reliability of suspension systems made of Kevlar

A broadband millimeter-wave spectrometer Z-Spec: sensitivity and ULIRGs

Z-Spec is a cryogenic, broadband, millimeter-wave grating spectrometer. It is capable of obtaining many spectral lines simultaneously because of its unprecedented broad bandwidth (185-305GHz). The bandpass covers the 1mm atmospheric transmission window with a resolving power of 250-400. Z-Spec uses 160 silicon nitride micromesh bolometers cooled down to less than 100mK for background-limited performance. The unique capability of Z-Spec to detect multiple lines simultaneously allows us to obtain information efficiently on the physical and chemical conditions of nearby Ultra-luminous Infrared Galaxies (ULIRGs) powered by starbursts or Active Galactic Nuclei. Here we report on new millimeter-wave broadband data for ULIRGs acquired with Z-Spec and the noise performance and achieved sensitivity in observations with the CSO. We found that during the observations the noise scales with the atmospheric opacity and can be explained well by our sensitivity model, considering the photon noise originating from the sky and the telescope, as well as the detector and electronics noise. The photon noise is found to dominate the total noise

A broadband millimeter-wave spectrometer Z-Spec: sensitivity and ULIRGs

Z-Spec is a cryogenic, broadband, millimeter-wave grating spectrometer. It is capable of obtaining many spectral lines simultaneously because of its unprecedented broad bandwidth (185-305GHz). The bandpass covers the 1mm atmospheric transmission window with a resolving power of 250-400. Z-Spec uses 160 silicon nitride micromesh bolometers cooled down to less than 100mK for background-limited performance. The unique capability of Z-Spec to detect multiple lines simultaneously allows us to obtain information efficiently on the physical and chemical conditions of nearby Ultra-luminous Infrared Galaxies (ULIRGs) powered by starbursts or Active Galactic Nuclei. Here we report on new millimeter-wave broadband data for ULIRGs acquired with Z-Spec and the noise performance and achieved sensitivity in observations with the CSO. We found that during the observations the noise scales with the atmospheric opacity and can be explained well by our sensitivity model, considering the photon noise originating from the sky and the telescope, as well as the detector and electronics noise. The photon noise is found to dominate the total noise

Z-Spec: a broadband, direct-detection, millimeter-wave spectrometer

Z-Spec is a broadband (195 - 310 GHz), direct-detection, millimeter-wave spectrometer with moderate resolution (R ~ 350) that we are building to observe CO rotational lines and atomic fine-structure lines in the recently discovered population of submillimeter galaxies. A large fraction of these sources cannot be identified optically and thus redshift determination is extremely difficult. The large instantaneous bandwidth of Z-Spec will allow measurement of redshifts up to z~4 via detection of two or more CO lines in a single spectrum. The spectrometer is based on a parallel-plate waveguide grating architecture that is substantially more compact than a conventional free-space grating system. The spectrometer and an array of 160 silicon nitride micromesh bolometers will be cooled to 100 mK to provide background-limited sensitivity. In addition to measuring the redshifts of sources discovered in submillimeter continuum surveys, Z-Spec will demonstrate a novel spectrometer concept well-suited for future far-infrared space missions

WaFIRS: a waveguide far-IR spectrometer: enabling spectroscopy of high-z galaxies in the far-IR and submillimeter

The discovery of galaxies beyond z~1 which emit the bulk of their luminosity at long wavelengths has demonstrated the need for high-sensitivity, broad-band spectroscopy in the far-IR/submm/mm bands. Because many of these sources are not detectable in the optical, long-wavelength spectroscopy is key to measuring their redshifts and ISM conditions. The continuum source list will increase in the coming decade with new ground-based instruments (SCUBA2, Bolocam, MAMBO), and the surveys of HSO and SIRTF. Yet the planned spectroscopic capabilities lag behind, in part due to the difficulty in scaling existing IR spectrograph designs to longer wavelengths. To overcome these limitations, we are developing WaFIRS, a novel concept for long-wavelength spectroscopy which utilizes a parallel-plate waveguide and a curved diffraction grating. WaFIRS provides the large (~60%) instantaneous bandwidth and high throughput of a conventional grating system, but offers a dramatic reduction in volume and mass. WaFIRS requires no space overheads for extra optical elements beyond the diffraction grating itself, and is two-dimensional because the propagation is confined between two parallel plates. Thus several modules could be stacked to multiplex either spatially or in different frequency bands. The size and mass savings provide opportunities for spectroscopy from space-borne observatories which would be impractical with traditional spectrographs. With background-limited detectors and a cooled 3.5 m telescope, the line sensitivity would be comparable to that of ALMA, with instantaneous broad-band coverage. We present the spectrometer concept, performance verification with a mm-wave prototype, and our progress toward a cryogenic astronomical instrument

Z-Spec: a broadband, direct-detection, millimeter-wave spectrometer

Z-Spec is a broadband (195 - 310 GHz), direct-detection, millimeter-wave spectrometer with moderate resolution (R ~ 350) that we are building to observe CO rotational lines and atomic fine-structure lines in the recently discovered population of submillimeter galaxies. A large fraction of these sources cannot be identified optically and thus redshift determination is extremely difficult. The large instantaneous bandwidth of Z-Spec will allow measurement of redshifts up to z~4 via detection of two or more CO lines in a single spectrum. The spectrometer is based on a parallel-plate waveguide grating architecture that is substantially more compact than a conventional free-space grating system. The spectrometer and an array of 160 silicon nitride micromesh bolometers will be cooled to 100 mK to provide background-limited sensitivity. In addition to measuring the redshifts of sources discovered in submillimeter continuum surveys, Z-Spec will demonstrate a novel spectrometer concept well-suited for future far-infrared space missions

Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma

<p>Abstract</p> <p>Background</p> <p>Interleukin-2 (IL-2) induces durable objective responses in a small cohort of patients with metastatic renal cell carcinoma (RCC) but the antigen(s) responsible for tumor rejection are not known. 5T4 is a non-secreted membrane glycoprotein expressed on clear cell and papillary RCCs. A modified vaccinia virus Ankara (MVA) encoding 5T4 was tested in combination with high-dose IL-2 to determine the safety, objective response rate and effect on humoral and cell-mediated immunity.</p> <p>Methods</p> <p>25 patients with metastatic RCC who qualified for IL-2 were eligible and received three immunizations every three weeks followed by IL-2 (600,000 IU/kg) after the second and third vaccinations. Blood was collected for analysis of humoral, effector and regulatory T cell responses.</p> <p>Results</p> <p>There were no serious vaccine-related adverse events. While no objective responses were observed, three patients (12%) were rendered disease-free after nephrectomy or resection of residual metastatic disease. Twelve patients (48%) had stable disease which was associated with improved median overall survival compared to patients with progressive disease (not reached vs. 28 months, p = 0.0261). All patients developed 5T4-specific antibody responses and 13 patients had an increase in 5T4-specific T cell responses. Although the baseline frequency of Tregs was elevated in all patients, those with stable disease showed a trend toward increased effector CD8+ T cells and a decrease in Tregs.</p> <p>Conclusion</p> <p><b>V</b>accination with MVA-5T4 did not improve objective response rates of IL-2 therapy but did result in stable disease associated with an increase in the ratio of 5T4-specific effector to regulatory T cells in selected patients.</p> <p>Trial registration number</p> <p>ISRCTN83977250</p

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29