17 research outputs found
The efficacy of surgical treatment of cerebral arteriovenous malformations in a single academic institution: a case series
Aim To report on patients who underwent surgical treatment of arteriovenous malformations (AVMs) at our institution.
Methods This retrospective single-center case series enrolled the patients who underwent surgical treatment of
pial AVM at the Department of Neurosurgery, University
Hospital Brno, between 2005 and 2019. The data are summarized as descriptive statistics presenting basic characteristics in all the patients and in sex or age subgroups.
Results Fifty patients were enrolled. The majority of AVMs
were of Spetzler-Martin grade II (n=27; 54%), localized supratentorialy (n=43; 86%), and half of AVMs were ruptured.
A total resection was performed in 48 patients (96%), and
a good overall outcome was achieved in 44 patients (88%).
Surgery-associated morbidity was 2%, and the mortality
rate was 0% due to meticulous selection of patients for
surgical treatment.
Conclusion Microsurgery is an appropriate method of
treatment for S-M grade I-III pial AVMs. Microsurgery may
be used to treat the majority of small-nidus AVMs with a
low mortality and morbidity, when precisely planned and
performed by an expert vascular team. The meticulous selection of patients for surgical treatment is crucial
MiR-34b is associated with clinical outcome in triple-negative breast cancer patients
<p>Abstract</p> <p>Background</p> <p>Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) represents the major phenotype of basal-like molecular subtype of breast cancer, characterized by higher incidence in young women and a very poor prognosis. MicroRNAs (miRNAs) are small non-coding RNAs playing significant role in the pathogenesis of many cancers including breast cancer. Therefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients.</p> <p>Methods</p> <p>Thirty-nine TNBC patients with available formalin-fixed paraffin-embedded (FFPE) tissues were enrolled in the study. MiR-34a, miR-34b, and miR-34c were analyzed using qRT-PCR and correlated to clinico-pathological features of TNBC patients.</p> <p>Results</p> <p>Expression levels of miR-34b significantly correlate with disease free survival (DFS) (<it>p </it>= 0.0020, log-rank test) and overall survival (OS) (<it>p </it>= 0.0008, log-rank test) of TNBC patients. No other significant associations between miR-34a, miR-34b, and miR-34c with available clinical pathological data were observed.</p> <p>Conclusions</p> <p>MiR-34b expression negatively correlates with disease free survival and overall survival in TNBC patients. Thus, miR-34b may present a new promising prognostic biomarker in TNBC patients, but independent validations are necessary.</p
Psychological and behavioural factors associated with sexual risk behaviour among Slovak students
Background: Knowledge about the prevalence of sexual risk behaviour (SRB) in adolescence is needed to prevent unwanted health consequences. Studies on SRB among adolescents in Central Europe are rare and mostly rely on a single indicator for SRB. This study aims to assess the association of behavioural and psychological factors with three types of SRB in adolescents in Central Europe. Methods: We obtained data on behavioural factors (having been drunk during previous month, smoking during previous week, early sexual initiation), psychological factors (self-esteem, wellbeing, extroversion, neuroticism, religiousness), and SRB (intercourse under risky conditions, multiple sexual partners, and inconsistent condom use) in 832 Slovak university students (response 94.3%). Results: Among those with sexual experience (62%), inconsistent condom use was the most prevalent risk behaviour (81% in females, 72% in males). With the exception of having been drunk in males, no factor was associated with inconsistent condom use. Regarding the other types of SRB, early sexual initiation was most strongly associated. In addition, other, mostly behavioural, factors were associated, in particular having been drunk. Conclusion: Results suggest that behavioural factors are more closely related to SRB than psychological factors. Associations differ by type of SRB and gender but offer few clues to target risk groups for inconsistent condom use. Results show a high need for health-promotion programmes in early adolescence that target SRB in conjunction with other health risk behaviours such as alcohol abuse
Reactive cyclic intermediates in the ProTide prodrugs activation: trapping the elusive pentavalent phosphorane
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Realizace kvantovych algeber.
Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi