GR-252 Solving Multiple Traveling Salesman Problem using K Means Clustering and Mixed Integer Programming - An Integrated Approach

In this research paper, we explore an efficient algorithm for multiple Traveling Salesman Problem (m-TSP) using an approach which combines K Means clustering algorithm and Mixed Integer Programming (MIP). The Traveling Salesman problem is an NP hard problem which relates to generation of minimum cost round trip tours for multiple salesmen visiting several cities in their territory. Our novel approach has the promise of reaching closer to the optimal solution as compared to heuristics-based approaches such as genetic algorithms

TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY PATIENT COMPLAINT DOSAGE FORM

Objective: Tablet is still most popular conventional dosage forms existing today, but the drawback of solid dosage forms is the difficulty in swallowing(dysphagia) or chewing in some patients particularly pediatric and geriatric patients. For this reason, orodispersible tablets (ODT) that can rapidlydissolve or disintegrate in the oral cavity have attracted a great deal of attention. The main objective of this review is to explore various methodologiesfor masking the taste of obnoxious drugs, applications, evaluation and also the recent trends in taste masking technologies when prepare a ODT.Methods: Pediatric and geriatric populations are the most sensitive to the bad taste of medicaments, thus in these cases patient compliance reduces.This reason is an initiative for the development of various taste masking technologies by which the characteristics of ODT is improved and goodpatient compliance is achieved.Results: ODTs have better patient acceptance and compliance and may offer improved biopharmaceutical properties, improved efficacy, and bettersafety compared with conventional oral dosage forms. Prescription ODT products initially were developed to overcome the difficulty in swallowingconventional tablets among pediatric, geriatric, and psychiatric patients with dysphagia.Conclusion: In this review, various techniques discussed which can help to overcome bitter taste of active pharmaceutical ingredients as well aslargely improve the product preference among patients. It will also enhance the quality of the treatment provided to patients, especially children andolder patients. Furthermore, various techniques could be combined to develop palatable and cost-effective ODTs.Keywords: Orodispersible tablet, Taste masking, Patient compliance

Liposomes: A targeted drug delivery system- A review

Liposomes are a novel drug delivery system (NDDS), which are vesicular structures consisting of hydrated bilalyers which form spontaneously whenphospholipids are dispersed in water. They are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the siteof action. It has been a study interest in the development of a NDDS. Liposomes are colloidal spheres of cholesterol non-toxic surfactants, sphingolipids, glycolipids, long chain fatty acids and even membrane proteins and drug molecules or it is also called vesicular system. It is differ in size, composition and charge. It is a drug carrier loaded with great variety of molecules such as small drug molecules, proteins, nucleotides and even plasmids. Few drugs are also formulated as liposomes to improve their therapeutic index. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. The focus of this review is to the various method of preparation, characterization of liposomes, advantages and applications etc

A brief study on Neem (Azarrdirachta indica a.) and its application-A review

Neem, Azadirachta indica A. is a tree, which has a wide application in animal kingdom. Azadirachta indica is fast growing evergreen popular tree found commonly in India, Africa and America. In the application of Neem, Neem used as Fertilizer, Manure, urea coating agent, fumigant, pesticide, Soil Conditioner and Neem pest control is very beneficial for proper crop and pest management. This review is mainly focused on application of neen

History of plants and animal products in the treatment of human disease-A review

Advances in nutrition research during the past few decades have changed scientist’s understanding of the contribution of vegetarian diets and nonvegetarian diets to human health and disease. Diets largely based on plant foods, such as well-balanced vegetarian diets, could best prevent nutrient deficiencies as well as diet-related chronic diseases. However, restrictive or unbalanced vegetarian diets may lead to nutritional deficiencies, particularly in situations of high metabolic demand. Recent scientific advances seem to have resulted in a paradigm shift: diets largely based on plant foods, such as well-balanced vegetarian diets, are viewed more as improving health than as causing disease, in contrast with meat-based diets

(R2028) A Brief Note on Space Time Fractional Order Thermoelastic Response in a Layer

In this study, a one-dimensional layer of a solid is used to investigate the exact analytical solution of the heat conduction equation with space-time fractional order derivatives and to analyze its associated thermoelastic response using a quasi-static approach. The assumed thermoelastic problem was subjected to certain initial and boundary conditions at the initial and final ends of the layer. The memory effects and long-range interaction were discussed with the help of the Caputo-type fractional-order derivative and finite Riesz fractional derivative. Laplace transform and Fourier transform techniques for spatial coordinates were used to investigate the solution of the temperature distribution and stress functions. Numerical investigations are also shown graphically for non-dimensional temperature and stress for different space and time fractional derivative values, respectively. In addition, some applicable limiting cases are discussed for standard equations, such as wave equation, Laplace equation, and diffusion equation

Evaluation and Comparison of Formocresol and Sodium Hypochlorite as Pulpotomy Medicaments in Treatment of Mandibular Primary Molars - A Randomized Controlled Study

Background: the main idea behind the pulpotomy of a primary tooth is to remove the infected or inflamed coronal pulp tissues and cover the pulp with a suitable medicament or dressing which promotes healing and preserve the vitality of the teeth especially in young permanent teeth. A medicament should be biologically compatible, have healing capabilities, should be non cytotoxic, or mutagenic and with no carcinogenic potential. Aim: the main aim of the study was to compare and evaluate the efficacy of commonly used two medicaments i.e. formocresol and sodium hypochlorite in pulpotomy of mandibular primary teeth. Material and methodology: a randomized controlled single blinded clinical trial was done on 50 subjects of age ranging from 3 to 6 years with bilateral mandibular first or second molar requiring pulpotomy. The subjects were randomly divided into two groups with 25 subjects in each. Group I, consisted of subjects on which formocresol medicament was used after extirpation of coronal pulp while in Group II, 3% sodium hypochlorite was used. Clinical along with the radiographic signs and symptoms were blindly recorded at an interval of 1, 3, 6 and 12 months respectively. Results: Statistically significant results were obtained in group II, when patients treated with 3% sodium hypochlorite. There was no major difference between the two medicaments used, but to the various adverse effects of formocresol, its usage has been limited. Conclusion: within the limitation of the study, it was concluded that sodium hypochlorite medicament proved to have better prognosis and can be suggested as a pulpotomy agent for primary teeth. Although formocresol was found to have similar significant results can also be used as a medicament. Keywords: Formocresol, Pulpotomy, Primary Teeth, Sodium Hypochlorit

Tibialis anterior muscle hernia : a case of chronic, dull pain and swelling in leg diagnosed by dynamic ultrasonography

BACKGROUND: Symptomatic muscle hernias are not uncommon in the lower extremities and are a rare cause of chronic leg pain. They are most commonly seen in the tibialis anterior muscle, occurring through fascial defects, usually after trauma. There are about 200 cases of muscle hernias described in the literature. The diagnosis is challenging as most of the patients present with non-specific chronic leg pain. Dynamic muscle ultrasonography at rest and at stress is often used for the diagnosis. CASE REPORT: We describe a case of tibialis anterior muscle hernia presenting with persistent dull pain and swelling along the anterior aspect of the leg on straining the leg muscles. Dynamic ultrasonography was performed, which showed a defect in the fascial sheath of the muscle through which the tibialis anterior muscle herniated and produced a focal bulge along the anterior aspect of the leg. Based upon physical examination and dynamic ultrasonographic findings, a diagnosis of tibialis anterior muscle hernia was made. CONCLUSIONS: Tibialis anterior muscle hernia is a rare diagnosis and should be included in the differential diagnosis in a patient with chronic leg pain and swelling. Dynamic ultrasound is crucial in confirming the diagnosis and should be done on straining the muscles of the affected limb

Formulation and evaluation of chitosan containing mucoadhesive buccal patches of metoprolol succinate

Mucoadhesive buccal patches containing metoprolol succinate were prepared using the solvent casting method. Chitosan was used as bioadhesive polymer and different ratios of chitosan to PVP K-30 were used. The patches were evaluated for their physical characteristics like mass variation, drug content uniformity, folding endurance, ex vivo mucoadhesion strength, ex vivo mucoadhesion time, surface pH, in vitro drug release, and in vitro buccal permeation study. Patches exhibited controlled release for a period of 8 h. The mechanism of drug release was found to be non-Fickian diffusion and followed the first-order kinetics. Incorporation of PVP K-30 generally enhanced the release rate. Swelling index was proportional to the concentration of PVP K-30. Optimized patches (F4) showed satisfactory bioadhesive strength of 9.6 ± 2.0 g, and ex vivo mucoadhesion time of 272 minutes. The surface pH of all patches was between 5.5 and 6.8 and hence patches should not cause irritation in the buccal cavity. Patches containing 10 mg of drug had higher bioadhesive strength with sustained drug release as compared to patches containing 20 mg of drug. Good correlation was observed between the in vitro drug release and in vitro drug permeation with a correlation coefficient of 0.9364. Stability study of optimized patches was done in human saliva and it was found that both drug and buccal patches were stable