Lepton number violation in Little Higgs model

In this note we examine the constraints imposed by muon anomalous magnetic moment ($(g-2)_\mu$) and $\mu^- \to e^+ e^- e^-$ on lepton number violating (LNV) couplings of the triplet Higgs in Little Higgs (LH) model.Comment: revtex4.0 file, 5 pages including 8 eps figures, version to appear in Phys. Rev.

FORMULATION AND IN VITRO EVALUATION OF SALBUTAMOL SULPHATE AND THEOPHYLLINE EXTENDED-RELEASE TABLETS USING MODIFIED POLYMERS

Objective: The main objective of this research work was to design, prepare and evaluate extended release (ER) tablets of anti-asthmatic drugs (salbutamol sulphate and theophylline) by direct compression method using diverse ratios of hydroxypropyl methylcellulose (HPMC K100M) and ethyl cellulose (EC) along with some other excipients.Methods: Extended-release matrix tablets of salbutamol sulphate and theophylline were successfully fabricated by direct compression method and coded the formulations as F1 to F7 depending on the ratios of modified polymers. The core tablets composed of hydrophilic polymers of various ratios that allow the discharge of drugs at a controlled rate after coming in contact with the aqueous medium. The designed tablets were subjected to various assessment parameters i.e. friability test, hardness test, drug content consistency and In vitro dissolution tests.Results: Prepared formulations were subjected to various assessment parameters and the findings obtained were within the prescribed limit. To perform the in vitro drug dissolution tests of fabricated tablets, the calibration plots of pure drugs using various solvents i.e. 0.1N HCl, phosphate buffer (pH 6.8) and distilled water were plotted. Dosage forms F1-F7 containing ethyl cellulose and HPMC K100M in various concentration demonstrates the prolonged medications discharge for up to 8 h, among these formulations, F6 shows 95.32±0.24 % for salbutamol sulphate and 94.19±0.39 % for theophylline release at the end of 8 h. This finding reveals that a particular window of concentrations of ethylcellulose and HPMC K100M was capable of providing prolonged drugs discharge.Conclusion: The results obtained in this research work clearly showed a promising potential of extended-release tablets containing a specific ratio of HPMC K100M and ethylcellulose as a release rate controlling polymers for effective treatment of asthma and chronic obstructive pulmonary diseases (COPD)

A multimodal mixture-of-experts model for dynamic emotion prediction in movies

This paper addresses the problem of continuous emotion prediction in movies from multimodal cues. The rich emotion content in movies is inherently multimodal, where emotion is evoked through both audio (music, speech) and video modalities. To capture such affective information, we put forth a set of audio and video features that includes several novel features such as, Video Compressibility and Histogram of Facial Area (HFA). We propose a Mixture of Experts (MoE)-based fusion model that dynamically combines information from the audio and video modalities for predicting the emotion evoked in movies. A learning module, based on hard Expectation-Maximization (EM) algorithm, is presented for the MoE model. Experiments on a database of popular movies demonstrate that our MoE-based fusion method outperforms popular fusion strategies (e.g. early and late fusion) in the context of dynamic emotion prediction

Role of bone marrow infiltration in management of delayed union of long bones fracture

Background: Usually delayed union of fracture long bones are managed by putting a bone graft at fracture site , but bone grafting have donor site complication like scar, infection ,hernia ,gait disturbance , cosmetic problem, as well as recipient site complication like soft tissue trauma , de-vascularisation of fracture fragment. Bone marrow infiltration is a minimally invasive method done percutaneously. It is easy, safe procedure with no associated complications that may occur in bone grafting.Methods: This prospective study was conducted in the Department of orthopedics, Government Medical College, Kota from June 2011 to November 2013 to evaluate the efficacy of percutaneous bone marrow infiltration in cases of delayed union of long bones. 27 patients included in study with 28 bones, as one patient has given bone marrow injection in two bones (tibia & femur), so the cases included in study counted as 28 cases. The mean age of this study was 38.28 years, ranging from 18 years to 75 years.  All cases were follow up after 4 to 6 weeks and thereafter one month interval. Final follow up was taken when fracture site shows clinical and radiological sign of union.Results: Out of 23 united cases 19 had excellent results and 04 cases had good results. The five cases which fail to unite were taken as poor results.Conclusions: Bone marrow infiltration is a minimally invasive, safe bone graft substitute for delayed union of long bones and have less complications

Little Higgs model effects at γγ collider

Though the predictions of the standard model (SM) are in excellent agreement with experiments there are still several theoretical problems, such as fine-tuning and the hierarchy problem. These problems are associated with the Higgs sector of the SM, where it is widely believed that some "new physics" will take over at the TeV scale. One beyond the SM theory which resolves these problems is the little Higgs model. In this work we shall investigate the effects of the little Higgs model on γγ→γγ scattering, where the process γγ→γγ at high energies occurs in the SM through diagrams involving W, charged quark, and lepton loops (and is, therefore, particularly sensitive to any new physics)

Assessing the factors that influence a recurrence of congenital talipes equinovarus in children treated with the Ponseti method

Background: Congenital talipes equinovarus, also known as clubfoot, is one of the most common congenital malformations in pediatric orthopedics. With a checkered treatment history extending from Hippocrates' bandages to Kite's serial plaster cast application to surgical treatment, no single modality can claim to be a complete treatment. Methods: In a combined prospective and retrospective study at the Department of Orthopaedics of St. Stephen's Hospital, 192 patients with 292 clubfeet who met the inclusion criteria and received ethics committee approval were included. The purpose of the research was to identify early recurrence characteristics, undertake the Pirani scoring, and identify additional clinical characteristics to evaluate recurrence predictors. Results: In our study, out of 192 patients, 188 were successfully treated with the Ponseti casting technique combined with tendoachilles tenotomy; tenotomy was required in 177 patients (93%). Four patients were lost to follow-up. Nine out of sixty-one children in the six-month-to-one-year age group showed the maximum rate of recurrence (15%). The mean number of cast applications was 7.23. In all, 90% of children required casts ranging from four to eight in number. The syndromic association was seen in 10.4% of cases with club feet. Most common among them were neural tube defects (4.2%) and arthrogryposis (3% of cases). Fourteen out of 154 (or 9%) of the non-operated idiopathic patients had lateral border recurrence during an average follow-up of two years. According to the Pirani score, recurrence was seen in eight out of twenty (or 40% of) syndromic patients and five out of fourteen (or 35% of) operated cases. In 37% of recurrences, dynamic supination was observed. Conclusions: Even though Ponseti's approach to treating idiopathic clubfoot is widely regarded as the gold standard, recurrences are known to occur even in the best of circumstances. The most common cause of recurrence was poor brace compliance, with families citing a variety of reasons

In Vitro Antioxidant Activity of root extracts of Heliotropium eichwaldi Stued. ex DC

ABSTRACT In vitro antioxidant activity of methanolic and aqueous root extracts of Heliotropium eichwaldi Stued. ex DC. was determined by DPPH free radical scavenging assay and hydrogen peroxide scavenging activity. The extract revealed marked activity as a radical scavenger in a study indicating that extracts have ability to donate hydrogen. The absorption is stoichiometric in respect to the number of electrons taken up. Concentration of 0.1 mg/ml of methanolic extract (HME) and aqueous root extract (HAE) of Heliotropium eichwaldi exhibited 62.73% and 57.18% DPPH scavenging activity. The antioxidant activity of these extracts towards hydrogen peroxide was also reported. A 76.94% and 70.79% of inhibition of hydrogen peroxide was observed with HME and HAE respectively, when compared with control, at a concentration of 0.1 mg/ml using ascorbic acid as standard and positive control on analysis with UV-Visible Spectrophotometer. The results conclude that the extracts are a potential source of antioxidants of natural origin and may be a candidate for treating pathologies related to free radical oxidation due to its overall antioxidant effect in scavenging free radicals and active oxygen species

Prescribing pattern and pharmacoeconomic analysis of antidiabetic drugs

Background: Diabetes Mellitus is a worldwide growing problem causing threat to patient's health because of its association with various complications and comorbidities. It is a chronic disease requiring lifelong medication which further adds to the economic burden. The objective of this study was to evaluate the prescribing pattern and to do pharmacoeconomic analysis of prescribed antidiabetic drugs.Methods: This observational cross sectional study was conducted for 12 months duration in Outpatient Pharmacy of tertiary care hospital. Prescriptions with antidiabetic drugs were captured and evaluation of prescribing pattern along with pharmacoeconomic analysis of antidiabetic drugs was done.Results: A total of 611 prescriptions with antidiabetic drugs were analyzed. There were total 4034 drugs in all prescriptions with a mean of 6.6 drugs per prescription. 4.28% of drugs were prescribed by generic name and 58.9% of prescribed drugs were from essential drug list. Dual drug therapy was prescribed in maximum number of patients (42.2%) followed by monotherapy (28.8%). More commonly prescribed class of antidiabetic drugs was biguanides as monotherapy (n=119) and its combination with sulfonylureas was prescribed maximally among dual drug therapy (n=158). Cost of monthly therapy for antidiabetic drugs prescribed as monotherapy was least with Biguanides (₹ 98.89/ month) whereas combination of biguanides and thiazolidinediones was least expensive among dual drug therapy (₹ 216/ month).Conclusions: Biguanides was the most common prescribed class of antidiabetic drugs among monotherapy and its combination with sulfonylureas was most prescribed as dual drug therapy and both of these therapies were economical

Qualitative and Quantitative Determination of Secondary Metabolites and Antioxidant Potential of Leaf of Brahmi, Green Tea and Bulb of Onion Extracts

Utilization of herbs for medicinal purpose started in the early history of mankind several thousand years ago.In the last few years, there has been an exponential growth in the field of herbal medicine and gaining popularity both in developing and developed countries because of their natural origin and less side effects. Medicinal plants continue to be an important therapeutic aid for alleviating ailments of humankind. An antioxidant is a molecule capable of terminating the chain reactions that damage cells by removing free radical intermediates and inhibit other oxidation reactions by thereby reducing stress responsible for many degenerative disorders. The aim of the present study was to determine qualitative and quantitative phytochemical and in vitro antioxidant activities of leaf of Green tea, Brahmi and bulb of Onion collected from Bhopal region of Madhya Pradesh. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenol were determined by the well-known test protocol available in the literature. Quantitative analysis of phenolic content was carried out by Folins Ciocalteau reagent method. The in vitro antioxidant activity of methanolic extract of the leaf and bulb was assessed against DPPH assay method using standard protocols. Phytochemical analysis revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids. The total phenolic content of leaf of Green tea, Brahmi and bulb of Onion was 195.26 ± 12.64, 136.92 ± 21.73 and 112.23 ± 11.36 mg/100mg respectively. The activities of methanolic leaves and bulbs extract against DPPH assay method were concentration dependent with IC 50 values of ascorbic acid and extracts 20.05±1.86 and 55.98±2.56, 104.45±3.13, 144.37±5.45μg/ml respectively. These studies provided information for correct identification of this plant material. The diverse array of phytochemicals present in the plant thus suggests its therapeutic potentials which may be explored in drug manufacturing industry as well as in traditional medicine. Keywords: Green Tea, Brahmi, Onion, Phytochemical constituents, Antioxidant activit