Solid-to-solid isostructural transition in the hard sphere/attractive Yukawa system

A thermodynamically consistent density functional-perturbation theory is used to study the isostructural solid-to-solid transition which takes place in the hard sphere/attractive Yukawa system when the Yukawa tail is sufficiently short-ranged. A comparison with results for the square well potential allows us to study the effect of the attractive potential form on the solid-solid transition. Reasonable agreement with simulations is found for the main transition properties as well as for the phase diagram evolution with the the range of the attractive potential.Comment: 14 pages, latex, 5 figures available upon request: ([email protected]

Laser-treated electrospun fibers loaded with nano-hydroxyapatite for bone tissue engineering

Core-shell polycaprolactone/polycaprolactone (PCL/PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) electrospun fibers loaded with synthesized nanohydroxyapatite (HAn) were lased treated to create microporosity. The prepared materials were characterized by XRD, FTIR, TEM and SEM. Uniform and randomly oriented beadless fibrous structures were obtained in all cases. Fibers diameters were in the 150–300 nm range. Needle-like HAn nanoparticles with mean diameters of 20 nm and length of approximately 150 nm were mostly encase inside the fibers. Laser treated materials present micropores with diameters in the range 70–120 µm for PCL-HAn/PCL fibers and in the 50–90 µm range for PCL-HAn/PVAC material. Only samples containing HAn presented bioactivity after incubation during 30 days in simulated body fluid. All scaffolds presented high viability, very low mortality, and human osteoblast proliferation. Biocompatibility was increased by laser treatment due to the surface and porosity modification

Surface tension fluctuations and a new spinodal point in glass-forming liquids

The dramatic slowdown of glass-forming liquids has been variously linked to increasing dynamic and static correlation lengths. Yet, empirical evidence is insufficient to decide among competing theories. The random first order theory (RFOT) links the dynamic slowdown to the growth of amorphous static order, whose range depends on a balance between configurational entropy and surface tension. This last quantity is expected to vanish when the temperature surpasses a spinodal point beyond which there are no metastable states. Here we measure for the first time the surface tension in a model glass-former, and find that it vanishes at the energy separating minima from saddles, demonstrating the existence of a spinodal point for amorphous metastable order. Moreover, the fluctuations of surface tension become smaller for lower temperatures, in quantitative agreement with recent theoretical speculation that spatial correlations in glassy systems relax nonexponentially because of the narrowing of the surface tension distribution.Comment: 6 pages, 5 figure

Three-slit experiments and quantum nonlocality

An interesting link between two very different physical aspects of quantum mechanics is revealed; these are the absence of third-order interference and Tsirelson's bound for the nonlocal correlations. Considering multiple-slit experiments - not only the traditional configuration with two slits, but also configurations with three and more slits - Sorkin detected that third-order (and higher-order) interference is not possible in quantum mechanics. The EPR experiments show that quantum mechanics involves nonlocal correlations which are demonstrated in a violation of the Bell or CHSH inequality, but are still limited by a bound discovered by Tsirelson. It now turns out that Tsirelson's bound holds in a broad class of probabilistic theories provided that they rule out third-order interference. A major characteristic of this class is the existence of a reasonable calculus of conditional probability or, phrased more physically, of a reasonable model for the quantum measurement process.Comment: 9 pages, no figur

A Methane Isolated Planetary Mass Object in Orion

We report on the discovery of a free-floating methane dwarf toward the direction of the young star cluster sigma Orionis. Based on the object's far-red optical and near-infrared photometry and spectroscopy, we conclude that it is a possible member of this association. We have named it as S Ori J053810.1-023626 (S Ori 70 is the abridged name). If it is a true member of sigma Orionis, the comparison of the photometric and spectroscopic properties of S Ori 70 with state-of-the-art evolutionary models yields a mass of 3 (+5/-1) Jupiter mass for ages between 1 Myr and 8 Myr. The presence of such a low-mass object in our small search area (55.4 sq. arcmin) would indicate a rising substellar initial mass function in the sigma Orionis cluster even for planetary masses.Comment: Accepted for publication in the ApJ. Twelve pages, figures and tables include

Panchromatic observations and modeling of the HV Tau C edge-on disk

We present new high spatial resolution (<~ 0.1") 1-5 micron adaptive optics images, interferometric 1.3 mm continuum and 12CO 2-1 maps, and 350 micron, 2.8 and 3.3 mm fluxes measurements of the HV Tau system. Our adaptive optics images reveal an unusually slow orbital motion within the tight HV Tau AB pair that suggests a highly eccentric orbit and/or a large deprojected physical separation. Scattered light images of the HV Tau C edge-on protoplanetary disk suggest that the anisotropy of the dust scattering phase function is almost independent of wavelength from 0.8 to 5 micron, whereas the dust opacity decreases significantly over the same range. The images further reveal a marked lateral asymmetry in the disk that does not vary over a timescale of 2 years. We further detect a radial velocity gradient in the disk in our 12CO map that lies along the same position angle as the elongation of the continuum emission, which is consistent with Keplerian rotation around an 0.5-1 Msun central star, suggesting that it could be the most massive component in the triple system. We use a powerful radiative transfer model to compute synthetic disk observations and use a Bayesian inference method to extract constraints on the disk properties. Each individual image, as well as the spectral energy distribution, of HV Tau C can be well reproduced by our models with fully mixed dust provided grain growth has already produced larger-than-interstellar dust grains. However, no single model can satisfactorily simultaneously account for all observations. We suggest that future attempts to model this source include more complex dust properties and possibly vertical stratification. (Abridged)Comment: 26 pages, 11 figures, editorially accepted for publication in Ap

Combination of exosomes and near-infrared responsive gold nanoparticles: new selective and specific therapeutic vehicle

P602 Exosomes are extracellular vesicles (50 -150 nm of diameter) considered key elements for the intercellular communication. Although they are proposed to be ideal vehicles for the targeting of novel therapies, very little is known about the selectiveness and specificity of the transference processes involving exosomes released from different cells. PEGylated Hollow gold nanoparticles (PEG-HGNs) are near-infrared (NIR) responsive nanoparticles (NPs) which are able to generate localized heat by the use of NIR light leading to cell death when applying optical hyperthermia. In this study, we demonstrate the selectivity of in vitro exosomal transfer between certain cell types and how this phenomenon can be exploited to develop new specific vectors for advanced therapies. Firstly, PEG-HGNs were successfully incorporated in the exosome biogenesis pathway of placental stem cells (MSCs) and they were released as PEG-HGNs-loaded exosomes (PEGHGNs_ MSCs_EXOs). Exosomes were characterized by confocal microscopy, western blot, nanosight, zeta potential and electronic microscopy. Afterwards, time lapse microscopy and atomic emission spectroscopy demonstrated the selective transfer of the ..

The Substellar Mass Function in sigma Orionis

We combine results from imaging searches for substellar objects in the sigma Orionis cluster and follow-up photometric and spectroscopic observations to derive a census of the brown dwarf population in a region of 847 arcmin^2. We identify 64 very low-mass cluster member candidates in this region. We have available three color (IZJ) photometry for all of them, spectra for 9 objects, and K photometry for 27% of our sample. These data provide a well defined sequence in the I vs I-J, I-K color magnitude diagrams, and indicate that the cluster is affected by little reddening despite its young age (~5 Myr). Using state-of-the-art evolutionary models, we derive a mass function from the low-mass stars (0.2 Msol) across the complete brown dwarf domain (0.075 Msol to 0.013 Msol), and into the realm of free-floating planetary-mass objects (<0.013 Msol). We find that the mass spectrum (dN/dm ~ m^{-alpha}) increases toward lower masses with an exponent alpha = 0.8+/-0.4. Our results suggest that planetary-mass isolated objects could be as common as brown dwarfs; both kinds of objects together would be as numerous as stars in the cluster. If the distribution of stellar and substellar masses in sigma Orionis is representative of the Galactic disk, older and much lower luminosity free-floating planetary-mass objects with masses down to about 0.005 Msol should be abundant in the solar vicinity, with a density similar to M-type stars.Comment: Accepted for publication in ApJ. 19 pages, 3 figures include