Influence of Individual Saliva Secretion on Fluoride Bioavailability

The aim of this preliminary investigation was to compare the individual saliva secretion rate with the fluoride bioavailability in saliva after using sodium fluoride and amine fluoride

Relativistic Laser-Matter Interaction and Relativistic Laboratory Astrophysics

The paper is devoted to the prospects of using the laser radiation interaction with plasmas in the laboratory relativistic astrophysics context. We discuss the dimensionless parameters characterizing the processes in the laser and astrophysical plasmas and emphasize a similarity between the laser and astrophysical plasmas in the ultrarelativistic energy limit. In particular, we address basic mechanisms of the charged particle acceleration, the collisionless shock wave and magnetic reconnection and vortex dynamics properties relevant to the problem of ultrarelativistic particle acceleration.Comment: 58 pages, 19 figure

Craniometric measurements of artificial cranial deformations in Eastern European skulls

Anthropologischer Anzeiger, Volume 66, No. 2 (2008), p. 139–146.Standardized lateral cephalograms of eleven skulls with artificial cranial deformations from Eastern Europe and twenty normal skulls from the same population were made,digitized and imported into the AutoCAD 2005 computer program.The x- and y coordinates of defined measuring points were determined and angle measurements were made.The form difference of the skulls was tested with the Euclidean Distance Matrix Analysis (EDMA) and the difference of the angle measurements were compared statistically using the non-parametric Mann-Whitney test.All deformed skulls belonged to the tabular fronto-occipital type of deformation.The results of the EDMA and the angle measurements indicated significant differences for the neurocranium and the facial cranium in height between the normal and the deformed skulls, but not in the cranial length.It can be concluded that in Eastern Europe one method of cranial molding was used.The deformation of the neurocranium also affected the development of the facial cranium regarding facial height.This may indicate a dependency of the developmental fields of the neurocranium and facial cranium

Craniometric measurements of artificial cranial deformations in Eastern European skulls

Anthropologischer Anzeiger, Volume 66, No. 2 (2008), p. 139–146.Standardized lateral cephalograms of eleven skulls with artificial cranial deformations from Eastern Europe and twenty normal skulls from the same population were made,digitized and imported into the AutoCAD 2005 computer program.The x- and y coordinates of defined measuring points were determined and angle measurements were made.The form difference of the skulls was tested with the Euclidean Distance Matrix Analysis (EDMA) and the difference of the angle measurements were compared statistically using the non-parametric Mann-Whitney test.All deformed skulls belonged to the tabular fronto-occipital type of deformation.The results of the EDMA and the angle measurements indicated significant differences for the neurocranium and the facial cranium in height between the normal and the deformed skulls, but not in the cranial length.It can be concluded that in Eastern Europe one method of cranial molding was used.The deformation of the neurocranium also affected the development of the facial cranium regarding facial height.This may indicate a dependency of the developmental fields of the neurocranium and facial cranium

Analysis of the parameters of Franck–Condon and Herzberg–Teller interactions the molecules of substituted diphenylbutadienes

We have done quantitative analysis of parameters Franck-Condon and Herzberg-Teller interactions of substituted diphenylbutadiene with general formula all-trans-X-Ph-(C = C)2-Ph-Y (X, Y = H, NO2, N(CH3)2, NH2 various combinations). The research shows the influence of substituents on the vibronic parameters of characteristic bands, which describe the state (vibrations, types of deformation under excitation) of the phenyl ring and the polyene bridge at the diphenylbutadiene molecule. Results described impact of the substituent’s nature on the parameters of intra- and intermolecular interactions presents for the studied compounds

Analysis of vibronic interactions in the molecules of cross-conjugated ketones

We have done quantitative analysis of vibronic parameters of two cross-conjugated δ-dimethylaminoketones. The research shows the influence of С-N and C=O bonds in the rings, and the radicals with nitro compounds on the vibronic parameters of characteristic bands, which describe the state (vibrations, types of deformation under excitation) of the phenyl ring and the polyene bridge. Results described impact of the substituent’s nature on the parameters of intra- and intermolecular interactions presents for the studied compounds

Three-dimensional reconstruction of the suborbicularis oculi fat and the infraorbital soft tissue

The aim of this study was to reveal the histomorphological connections among the suborbicularis oculi fat (SOOF), the orbicularis oculi muscle (OOM), the superficial musculoaponeurotic system (SMAS), the infraorbital fat and the skin.Full graft tissue blocks of the infraorbital region with the skin, SMAS, OOM and SOOF were collected post mortem from one female and two male formalin-fixed body donors. Serial histological sections were made, stained and digitized. Digitalization and three-dimensional (3D) reconstruction of the histological meshwork were performed.SOOF was revealed as a fibro-adipose tissue underlying the OOM, which was strictly separated from the intraorbital fat pad by the orbital septum. SOOF, OOM and SMAS were connected by fibrous septa derived from the SOOF, traversing the OOM with division into multiple muscular bundles, continuing above the muscular plane by forming the SMAS and ending with skin insertion. In the infraorbital region, two different types of SMAS bordering the infraorbital fold have been recognized. Muscle cells have been demonstrated in the SMAS fibrous septa of both SMAS types.Together with the OOM, the SMAS and the skin, SOOF forms an anatomical functional unit. Muscular contraction of the OOM could be transferred by the SMAS to the skin level, producing periorbital mimic expression. The 3D reconstruction facilitates the comprehension of the morphological structure, its connections and space correlations in the infraorbital area. The morphological and topographical peculiarities of the infraorbital structures make it possible to conclude that surgical interventions in this area need to be elaborated and individualized. Keywords: Suborbicularis oculi fat, SOOF plastic surgery, Subcutaneous musculoaponeurotic system, SMAS, 3D reconstruction, Infraorbital soft tissu

Effect of carbamazepine on the activity of CYP3A4 isoenzyme in patients with alcohol addiction

According to literature data, isoenzyme CYP3A4 of cytochrome P450 is involved in biotransformation of drugs. At the same time, there is evidence that carbamazepine induces CYP3A4 activity. The purpose of the study was to evaluate the effect of carbamazepine on the CYP3A4 activity in patients with alcohol addiction. The study was performed on a group of 25 men with alcohol abuse, which received haloperidol during the exacerbation of addiction. The activity of CYP23A4 was evaluated using high performance liquid chromatography with mass spectrometry (HPLC-MS/MS) for determining 6-beta-hydroxycortisoI conversion to Cortisol in urine. The results were used to construct a plot and derive an equation of logarithmic regression reflecting the dependence of CYP3A4 activity on the dose of carbamazepine: y = (5.5-9.1) × 10-5 ΔΔx2. These data demonstrate a statistically significant effect of carbamazepine on the activity of CYP3A4 isoenzyme in patients with alcohol addiction treated by haloperidol

Effect of carbamazepine on the activity of CYP3A4 isoenzyme in patients with alcohol addiction

According to literature data, isoenzyme CYP3A4 of cytochrome P450 is involved in biotransformation of drugs. At the same time, there is evidence that carbamazepine induces CYP3A4 activity. The purpose of the study was to evaluate the effect of carbamazepine on the CYP3A4 activity in patients with alcohol addiction. The study was performed on a group of 25 men with alcohol abuse, which received haloperidol during the exacerbation of addiction. The activity of CYP23A4 was evaluated using high performance liquid chromatography with mass spectrometry (HPLC-MS/MS) for determining 6-beta-hydroxycortisoI conversion to Cortisol in urine. The results were used to construct a plot and derive an equation of logarithmic regression reflecting the dependence of CYP3A4 activity on the dose of carbamazepine: y = (5.5-9.1) × 10-5 ΔΔx2. These data demonstrate a statistically significant effect of carbamazepine on the activity of CYP3A4 isoenzyme in patients with alcohol addiction treated by haloperidol