Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis

学位記番号：医博甲1563

Differences in body composition assessments measured by air displacement plethysmography and magnetic resonance imaging in adult females

J-GLOBAL ID : 202201012804701108J-GLOBAL ID : 202101004237845144Magnetic resonance imaging （MRI） and air displacement plethysmography （ADP） are widely used methods for reliable body composition analysis （BCA）. This study aimed to compare the BCA assessments obtained between MRI and ADP methods in 14 adult females. BCA measurements such as whole-body mass, volume, density, fat mass and %fat mass were analyzed by both MRI and ADP methods. 　The masses, volumes and body densities obtained MRI and ADP method were both absolutely and relatively equaled. However, the %fat masses obtained MRI and ADP method were highly correlated （r＝0.950, p＜0.001）, while significant absolute differences in %fat mass were found between the two methods （p＜0.001）. 　It was suggested that the MRI method equivalently evaluated in mass, volume and body density compared with ADP method. Also, MRI method can be relatively evaluated the fat mass and %fat mass but it overestimated absolute values.1520860078898552704application/pdfdepartmental bulletin pape

Morphological characteristics of rhythmic gymnasts : A one-year longitudinal report

J-GLOBAL ID : 201901006623480864J-GLOBAL ID : 202201012804701108J-GLOBAL ID : 2021010042378451441520297128942605184application/pdfdepartmental bulletin pape

Differences between elite, junior and elite senior rowers in kinetics parameters during slide ergometer rowing

J-GLOBAL ID : 202101004237845144J-GLOBAL ID : 202201012804701108J-GLOBAL ID : 201801009314123820The rowing ergometer is usually installed on the floor, but it has been pointed out that the kinetics, kinematics, and coordination of muscles are different from rowing motion on water. In order to solve the above problems and simulate rowing operation on water, recently the slide ergometer in which two slides move forward and backward and the dynamic ergometer in which a stretcher moves forward have been developed. The purpose of this study was to characterize junior and senior rowers using a sliding ergometer. Mechanical variables such as handle/stretcher force as long as tempo- special variables and kinetics variables were compared between slide rowing ergometer conditions. A custom-made Air pressure resistance type rowing ergometer (Concept II model c indoor Rower) was used for this study. The sliding-type rowing ergometer was mounted on two ergometer slides (manufactured by Concept II). 　The subjects were 11 high school and college rowers who performed a 2000 m simulation using a sliding rowing ergometer. The calculated variables were the spatio-temporal variable of the handle, the mechanical output of the handle and the stretcher. Senior rowers had shorter drive phases and longer recovery phases. Senior rowers also had higher handle and stretcher forces. It is suggested that senior rowers utilize different techniques than juniors during rowing due to higher leg and handle strength and different drive and recovery times.1520297128938327296application/pdfdepartmental bulletin pape

Quantitative analysis of foot arch deformation and plantar load distribution pattern during running

J-GLOBAL ID : 202101004237845144J-GLOBAL ID : 201801009314123820J-GLOBAL ID : 202201012804701108The purpose of this study was to quantify the foot medial longitudinal arch deformation and related plantar load distribution during running. 　Plantar pressure measurement plate (Novel GmbH®, 100Hz), motion capture system (Oxford, 100Hz) and force plate (Kistler, 1KHz) were used as to synchronize each data in time domain. Plantar load distribution was divided into five sub-area based on anatomical measurement points on the foot. Medial longitudinal arch angle was calculated as the angle between the distal first metatarsal, navicular tuberosity and calcaneus, and first metatarsophalangeal joint angle as the angle between the hallux, distal and proximal first metatarsal. 　The plantar load was observed to shift to the forefoot during push off, and the medial longitudinal arch angle showed the largest change. Thereafter, the anterior ground reaction force tended to increase with dorsiflexion of the metatarsophalangeal joint. Medial longitudinal arch could be a flexible structure that absorbs plantar load during foot contact. It is assumed that the dorsiflexion of the first metatarsophalangeal joint during push off contributes to the increase in foot stiffness in order to support forward propulsion.1520860078895092480application/pdfdepartmental bulletin pape

Effect of the back plate positioning for start time performances for 5m and 10m distances in swimming kick start

J-GLOBAL ID : 202201012804701108J-GLOBAL ID : 202301019486094800J-GLOBAL ID : 200901085265547080J-GLOBAL ID : 202101004237845144The purpose of this study was to clarify the effects in the lower hip angle in different back plate positions has on the times of the 5 m and 10 m of a swim start. Seven male Japanese swimmers including national level athletes were selected as subjects. Each swimmer participated in three back plate positions；each dive using a different back plate position and recordings of time from the start to 15m were made. 10 motion captured systems were used to capture kinematics data, and two video cameras measured the time at each passing point. The results of this study showed that the 10m time was significantly shorter in the order of Front, Prefer, and Back. There was no difference in the take-off horizontal velocity, but the 10m time resulted to be shorter when the take-off angle was higher. The farther the distance between the back plate, the larger rear foot hip angle at the kick start stance of the start, and the earlier the start of extension of each joint angle. It is considered that this makes it easier to raise the upper body, which enables horizontal movement and increases the speed of the 10m time.1520860078898196096application/pdfdepartmental bulletin pape

Reaction Times of The Gyaku- and Kizami- tsuki in female collegiate karate athletes : Analysis from ground reaction forces and kinematics

J-GLOBAL ID : 201101073728331279J-GLOBAL ID : 201801007052633411J-GLOBAL ID : 202201012804701108J-GLOBAL ID : 201801009314123820J-GLOBAL ID : 202101004237845144The purpose of this study was to analyze the kinematics and kinetics of how karate players respond to LED light stimuli and opponents when performing kizami- and gyaku-tsuki. The effects of the distance between the attacker and the opponent, and the differences in event types and levels on the reaction time were also examined. Thirteen female university student karate athletes （kumite international level：n＝2, kumite college level：n＝6, kata：n＝5） participated in this study. Fourteen motion capture cameras and three force plates were used to record kizami-tsuki and gyaku-tsuki movements to LED light stimuli and the opponent. Kinetics and kinematics analysis showed no difference in reaction time to LED light stimuli among kumite, kata, and competition levels, but international level kumite athletes tended to have the shorter reaction time to opponent's movements. In conclusion, our results suggest that international-level kumite players have an excellent ability to predict and judge the movements of their opponents.1520297128939472640application/pdfdepartmental bulletin pape

Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis

Abstract Background Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels. Neutropenia and cardiac events including sinus node dysfunction (SND) and atrioventricular block have been previously reported as adverse effects of LCM. To date, there have been no reports of severe agranulocytosis resulting in death associated with LCM. Additionally, there have been no reports of concomitant SND and agranulocytosis after LCM administration. Herein we report the first case of LCM-induced severe SND followed by agranulocytosis. Case presentation The patient with focal epilepsy was initiated on LCM 100 mg/day and the dose was increased to 200 mg/day on the 9th hospital day. Severe SND developed on the 10th hospital day and LCM was discontinued. Thereafter agranulocytosis appeared on the 11th hospital day, and the patient died from septic shock on the 15th hospital day. Conclusions This case illustrates the need for careful follow-up of the electrocardiogram and the complete blood cell counts when initiating LCM. Moreover, it should be noticed that various side effects may occur simultaneously in the early period of LCM use, even for a short time and at low dosages

診断にMRI拡散強調画像が有用であった化膿性脳室炎の１例

症例は 73歳女性である.頭痛,嘔気,発熱,項部硬直,意識障害,排尿障害を呈し当科に入院した.髄液検査で著明な炎症細胞増多あり,髄液および血液の培養検査で B群連鎖球菌陽性であり,細菌性髄膜炎と診断された. MRI拡散強調画像では左右の側脳室後角およびくも膜下腔に高信号病変がみられた. T2強調画像, FLAIR画像,ガドリニウム造影 T1強調画像では明らかな病変は指摘されなかった.細菌性髄膜炎により脳室内およびくも膜下腔に膿が波及した結果,化膿性脳室炎を呈し,拡散強調画像で高信号病変として指摘されたものと考えられた.抗生剤およびステロイド投与により排尿障害以外の後遺症なく症状は改善し,拡散強調画像でも高信号病変は消失した.本症例により,細菌性髄膜炎や化膿性脳室炎の診断および病態の評価に拡散強調画像の撮影が有用である可能性が示された