Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences

This compendium and the accompanying floppy diskettes are the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts that it comprises: (1) Nuclear Acid Alignments and Sequences; (2) Amino Acid Alignments; (3) Analysis; (4) Related Sequences; and (5) Database Communications. Information within all the parts is updated throughout the year on the Web site, http://hiv-web.lanl.gov. While this publication could take the form of a review or sequence monograph, it is not so conceived. Instead, the literature from which the database is derived has simply been summarized and some elementary computational analyses have been performed upon the data. Interpretation and commentary have been avoided insofar as possible so that the reader can form his or her own judgments concerning the complex information. In addition to the general descriptions of the parts of the compendium, the user should read the individual introductions for each part

Photograph of Leon Murray Schwartz

Portrait of Schwartz at approximately 40 years old

Management of hepatitis B

The NIH Consensus Development Conference on Management of Hepatitis B was held October 20-22, 2008.Conference partners: Centers for Disease Control and Prevention, U.S. Food and Drug Administration.Belongia EA, Costa J, Gareen IF, Grem JL, Inadomi JM, Kern ER, McHugh JA, Petersen GM, Rein MF, Sorrell MF, Strader DB, Trotter HT. National Institutes of Health Consensus Development Conference Statement: management of hepatitis B. Ann Intern Med. 2009;150:104-10

Unusual asymmetry of methyl /sup 2/H EFG in thymine: a solid state deuterium NMR and ab initio MO study

Solid-state /sup 2/H NMR spectroscopy is a powerful method of studying molecular motion in the solid state. The power of this technique derives from the facts that quadrupole coupling is the dominant interaction and the electric field gradient (EFG) tensor is usually axially symmetric for a deuteron bonded to carbon, with the unique axis along the C-D bond. In the case of a methyl group, rapid 3-fold rotation yields an averaged EFG whose symmetry axis is along the rotation axis, and the corresponding powder pattern is axially symmetric (eta less than or equal to 0.01) with a quadrupole splitting of ca. 40 kHz. They are interested in obtaining spectra of thymidine and ribothymidine, deuteriated at the methyl positions, to study motion of nucleotide bases in DNA and tRNA, respectively. In their initial work they are studying the dynamics of the model compound, thymine-methyl-d/sub 3/. Inversion-recovery /sup 2/H NMR spectra of this compound clearly showed the T/sub 1/ anisotropy predicted for 3-fold methyl jumps. The linear Arrhenius plot of correlation time, tau/sub c/, against 1/T (where tau/sub c/ = tau/sub 0/ exp(E/RT)) yielded an apparent activation energy of 6.9 kJ/mol and a preexponential factor, tau/sub 0/, of 2 x 10/sup -13/ s. These results show that the /sup 2/H spin-lattice relaxation is determined by the 3-fold methyl motion. However, this motion does not account for the asymmetry in the observed line shape

NIH Consensus Development Conference on Celiac Disease : June 28-30, 2004, William H. Natcher Conference Center, National Institutes of Health, Bethesda, Maryland /

Shipping list no.: 2004-0216-P.Includes bibliographical references.Mode of access: Internet