Correlating University Students’ Academic Attainment and Sense of Hope in Science Education: A survey from a Nigerian University

Existing contexts within the Nigerian higher education system have taken a toll on the extrinsic motivation of students. In view of the effect of these dynamics on the overall objective of science education, students’ sense of hope holds a unique significance for academic wholeness. This study employs an ex post facto research design to examine the relationship between science education students’ sense of hope and their academic achievement. The sample comprises 69 second-year students drawn from the science education programmes of a federal university in North Central Nigeria. The Trait Hope Scale and student written responses on personal motivation for science education provided data that were analyzed using mean, standard deviation, t-test, correlation, and thematic analysis. The findings reveal overall high mean scores for sense of hope (x ̅=51.812, SD = 6.687), a weak positive correlation between hope and students’ CGPA that was not statistically significant, and broad desire for acquiring knowledge for society building. The implications of these outcomes for resilience in university education and human capacity development were discussed

Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.

Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20-50 years after exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we show that exomic intratumour heterogeneity varies widely across the cohort. Phylogenetic tree topology ranges from linear to highly branched, reflecting a steep gradient of genomic instability. Using transfer learning, we detect repeated evolution, resolving 5 clusters that are prognostic, with temporally ordered clonal drivers. BAP1/-3p21 and FBXW7/-chr4 events are always early clonal. In contrast, NF2/-22q events, leading to Hippo pathway inactivation are predominantly late clonal, positively selected, and when subclonal, exhibit parallel evolution indicating an evolutionary constraint. Very late somatic alteration of NF2/22q occurred in one patient 12 years after surgery. Clonal architecture and evolutionary clusters dictate MPM inflammation and immune evasion. These results reveal potentially drugable evolutionary bottlenecking in MPM, and an impact of clonal architecture on shaping the immune landscape, with potential to dictate the clinical response to immune checkpoint inhibition

Correlating University Students’ Academic Attainment and Sense of Hope in Science Education: A survey from a Nigerian University

Published Journal Article in International Journal of Education and Knowledge Management (IJEKM) 1(3