(Acetylacetonato-j2O,O0)carbonyl[tris(4- chlorophenyl)phosphane-jP]rhodium(I)

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(Acetylacetonato-κ2O,O′)carbonyl[tris(4-chlorophenyl)phosphane-κP]rhodium(I)

The title compound, [Rh(C5H7O2)(C18H12Cl3P)(CO)], contains the bidentate acetylacetonate ligand coordinated to the RhI atom, forming a chelate ring [Rh—O = 2.0327 (15) and 2.0613 (14) Å]. The RhI atom is additionally coordinated by one P [Rh—P = 2.2281 (6) Å] and one carbonyl C [Rh—C = 1.812 (2) Å] atom, resulting in a slightly distorted square-planar geometry. The molecules are packed to minimize steric hindrance with the phosphanes positioned above and below the slightly distorted square geometrical plane

Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds

The rational development of multinuclear arene ruthenium complexes (arene = p-cymene, hexamethylbenzene) from generation 1 (G1) and generation 2 (G2) of 4-iminopyridyl based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)n (n = 4 or 8, DAB = diaminobutane) has been accomplished in order to exploit the ‘enhanced permeability and retention’ (EPR) effect that allows large molecules to selectively enter cancer cells. Four compounds were synthesised, i.e. [{(p-cymene)RuCl2}4G1] (1), [{(hexamethylbenzene)RuCl2}4G1] (2), [{(p-cymene)RuCl2}8G2] (3), and [{(hexamethylbenzene)RuCl2}8G2] (4), by first reacting DAB-(NH2)n with 4-pyridinecarboxaldehyde and subsequently metallating the iminopyridyl dendrimers with [(p-cymene)RuCl2]sub>2 or [(hexamethylbenzene)RuCl2]2. The related mononuclear complexes [(p-cymene)RuCl2(L)] (5) and [(hexamethylbenzene)RuCl2 (L)] (6) were obtained in a similar manner from N-(pyridin-4-ylmethylene)propan-1-amine (L). The molecular structure of 5 has been determined by X-ray diffraction analysis and the in vitro anticancer activities of the mono-, tetra- and octanuclear complexes 1–6 studied on the A2780 human ovarian carcinoma cell line showing a close correlation between the size of the compound and cytotoxicity