Bagaimana Kaitan Kecemasan Komunikasi Pada Korban Perundungan dengan Dukungan Sosial

There are a lot of impacts of bullying, one of the impact is communication apprehension, which had a long term effect on victims in socializing on vary situations. This study aimed to determine how social support related to overcome communication apprehension on bullying victims. This research used quantitative approach with subject that consist of 106 samples using the purposive sampling technique. Data collection method used is Personal Report of Communication Apprehension 24 Version (PRCA-24) and 2-Way Social Support Scale (2-Way SSS). Research data was analyzed with Kendall’s Tau test. The result showed that there is negative and significant correlation between social support and communication apprehension on bullying victims by the calculated of r value = -0.683 and p value = 0.000 < 0.0. In conclusion, there is correlation between social support and communication apprehension on bullying victims. This means that the higher the social support, the lower the communication anxiety, and vice versa.Salah satu dampak dari perundungan adalah adanya kecemasan komunikasi yang berefek jangka panjang pada korban dalam bersosialisasi. Penelitian ini bertujuan untuk mengetahui bagaimana dukungan social berhubungan dalam mengatasi kecemasan komunikasi pada korban perundungan. Penelitian kuantitatif ini menggunakan sampel penelitian sebanyak 106 sampel usia 12-18 tahun dengan teknik purposive sampling. Alat ukur yang digunakan dalam penelitian yaitu PRCA-24 dan 2-Way SSS dengan reliabilitas variabel bebas sebesar 0.949 dan variabel terikat sebesar 0.918. Teknik analisa data menggunakan uji korelasi Kendall’s Tau_b dengan nilai r hitung = -0.683 dan p = 0.000 < 0.05. Hasil perhitungan menunjukkan adanya hubungan negatif dukungan sosial dengan kecemasan komunikasi pada korban perundungan. Artinya semakin tinggi dukungan sosial, maka semakin rendah kecemasan komunikasi, begitu pun sebaliknya

Mindcast: Mindfulness Podcast Meningkatkan Mindfulness pada Burn-Out millennial Generation

Tujuan Studi : Penelitian ini bertujuan untuk menganalisis efektivitas treatment mindcast(mindfulness podcast) berupa media podcast pada generasi milenial yang mengalami burn-out. Metodologi : Sampel penelitian ini sebanyak 34 subjek dengan menggunakan teknik purposive sampling. Penelitian ini menggunakan pendekatan pra-eksperimen dengan desain yang digunakan adalah one group pre-test post-test design. Teknik analisis data menggunakan Independent Sample T-Test. Hasil : Hasil penelitian menunjukkan: (1) Ada peningkatan mindfulness pada burn-outmillennial generation setelah diberi treatment mindcast dengan nilai p = 0,000(p &lt; 0,05); t hitung sebesar -4,870 (&gt; t tabel = 2,037). (2) Ada penurunan tingkat burn-out pada burn-outmillennial generation setelah diberi treatment mindcast dengan nilai p = 0,000(p &lt; 0,05); t hitung sebesar 3,905 (&gt; t tabel = 2,037). Alat ukur yang digunakan menggunakan skala burn-outyang dirancang sendiri oleh peneliti dan skala mindfulness berupa Five Facet Mindfulness Questionnaire (FFMQ) dengan skala model likert. Data yang terkumpul dianalisis dengan uji normalitas dan uji t-test bantuan program SPSS 25.0 for windows 8. Manfaat : Berdasarkan hasil penelitian ini dapat diketahui bahwa pemberian treatment dapat dilakukan dengan media podcast, terutama pada generasi milenial yang mengalami burn-ou

Cognitive Networks Achieve Throughput Scaling of a Homogeneous Network

We study two distinct, but overlapping, networks that operate at the same time, space, and frequency. The first network consists of $n$ randomly distributed \emph{primary users}, which form either an ad hoc network, or an infrastructure-supported ad hoc network with $l$ additional base stations. The second network consists of $m$ randomly distributed, ad hoc secondary users or cognitive users. The primary users have priority access to the spectrum and do not need to change their communication protocol in the presence of secondary users. The secondary users, however, need to adjust their protocol based on knowledge about the locations of the primary nodes to bring little loss to the primary network's throughput. By introducing preservation regions around primary receivers and avoidance regions around primary base stations, we propose two modified multihop routing protocols for the cognitive users. Base on percolation theory, we show that when the secondary network is denser than the primary network, both networks can simultaneously achieve the same throughput scaling law as a stand-alone network. Furthermore, the primary network throughput is subject to only a vanishingly fractional loss. Specifically, for the ad hoc and the infrastructure-supported primary models, the primary network achieves sum throughputs of order $n^{1/2}$ and $\max\{n^{1/2},l\}$, respectively. For both primary network models, for any $\delta>0$, the secondary network can achieve sum throughput of order $m^{1/2-\delta}$ with an arbitrarily small fraction of outage. Thus, almost all secondary source-destination pairs can communicate at a rate of order $m^{-1/2-\delta}$.Comment: 28 pages, 12 figures, submitted to IEEE Trans. on Information Theor

Differential Fibroblast Growth Factor 8 (FGF8)-Mediated Autoregulation of Its Cognate Receptors, Fgfr1 and Fgfr3, in Neuronal Cell Lines

Fibroblast growth factors (FGFs) mediate a vast range of CNS developmental processes including neural induction, proliferation, migration, and cell survival. Despite the critical role of FGF signaling for normal CNS development, few reports describe the mechanisms that regulate FGF receptor gene expression in the brain. We tested whether FGF8 could autoregulate two of its cognate receptors, Fgfr1 and Fgfr3, in three murine cell lines with different lineages: fibroblast-derived cells (3T3 cells), neuronal cells derived from hippocampus (HT-22 cells), and neuroendocrine cells derived from hypothalamic gonadotropin-releasing hormone (GnRH) neurons (GT1-7 cells). GnRH is produced by neurons in the hypothalamus and is absolutely required for reproductive competence in vertebrate animals. Several lines of evidence strongly suggest that Fgf8 is critical for normal development of the GnRH system, therefore, the GT1-7 cells provided us with an additional endpoint, Gnrh gene expression and promoter activity, to assess potential downstream consequences of FGF8-induced modulation of FGF receptor levels. Results from this study suggest that the autoregulation of its cognate receptor represents a common downstream effect of FGF8. Further, we show that Fgfr1 and Fgfr3 are differentially regulated within the same cell type, implicating these two receptors in different biological roles. Moreover, Fgfr1 and Fgfr3 are differentially regulated among different cell types, suggesting such autoregulation occurs in a cell type-specific fashion. Lastly, we demonstrate that FGF8b decreases Gnrh promoter activity and gene expression, possibly reflecting a downstream consequence of altered FGF receptor populations. Together, our data bring forth the possibility that, in addition to the FGF synexpression group, autoregulation of FGFR expression by FGF8 represents a mechanism by which FGF8 could fine-tune its regulatory actions

Taselisib (GDC-0032), a Potent -Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations

Activating PIK3CA genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC), and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K inhibitor with potent activity against p110α, in combination with radiation in HNSCC

Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function

Many viruses downregulate their cognate receptors, facilitating virus replication and pathogenesis via processes that are not yet fully understood. In the case of herpes simplex virus 1 (HSV1), the receptor binding protein glycoprotein D (gD) has been implicated in downregulation of its receptor nectin1, but current understanding of the process is limited. Some studies suggest that gD on the incoming virion is sufficient to achieve nectin1 downregulation, but the virus-encoded E3 ubiquitin ligase ICP0 has also been implicated. Here we have used the physiologically relevant nTERT human keratinocyte cell type – which we have previously shown to express readily detectable levels of endogenous nectin1 – to conduct a detailed investigation of nectin1 expression during HSV1 infection. In these cells, nectin1, but not nectin2 or the transferrin receptor, disappeared from the cell surface in a process that required virus protein synthesis rather than incoming virus, but did not involve virus-induced host shutoff. Furthermore, gD was not only required but was sufficient for nectin1 depletion, indicating that no other virus proteins are essential. NK cells were shown to be activated in the presence of keratinocytes, a process that was greatly inhibited in cells infected with wild-type virus. However, degranulation of NK cells was also inhibited in ΔgD-infected cells, indicating that blocking of NK cell activation was independent of gD downregulation of nectin1. By contrast, a superinfection time-course revealed that the ability of HSV1 infection to block subsequent infection of a GFP-expressing HSV1 was dependent on gD and occurred in line with the timing of nectin1 downregulation. Thus, the role of gD-dependent nectin1 impairment during HSV infection is important for virus infection, but not immune evasion, which is achieved by other mechanisms

CHILES: HI morphology and galaxy environment at z=0.12 and z=0.17

We present a study of 16 HI-detected galaxies found in 178 hours of observations from Epoch 1 of the COSMOS HI Large Extragalactic Survey (CHILES). We focus on two redshift ranges between 0.108 <= z <= 0.127 and 0.162 <= z <= 0.183 which are among the worst affected by radio frequency interference (RFI). While this represents only 10% of the total frequency coverage and 18% of the total expected time on source compared to what will be the full CHILES survey, we demonstrate that our data reduction pipeline recovers high quality data even in regions severely impacted by RFI. We report on our in-depth testing of an automated spectral line source finder to produce HI total intensity maps which we present side-by-side with significance maps to evaluate the reliability of the morphology recovered by the source finder. We recommend that this become a common place manner of presenting data from upcoming HI surveys of resolved objects. We use the COSMOS 20k group catalogue, and we extract filamentary structure using the topological DisPerSE algorithm to evaluate the \hi\ morphology in the context of both local and large-scale environments and we discuss the shortcomings of both methods. Many of the detections show disturbed HI morphologies suggesting they have undergone a recent interaction which is not evident from deep optical imaging alone. Overall, the sample showcases the broad range of ways in which galaxies interact with their environment. This is a first look at the population of galaxies and their local and large-scale environments observed in HI by CHILES at redshifts beyond the z=0.1 Universe.Comment: 23 pages, 12 figures, 1 interactive 3D figure, accepted to MNRA

Frontiers in photonics spot light

Recognizing remarkable achievements and innovations is an important mission in scientific dissemination. The editors of Frontiers in Photonics would like to acknowledge and give visibility to some of the best recent research outputs and to their authors in this spot-light review

St. Louis Area Earthquake Hazards Mapping Project: Seismic and Liquefaction Hazard Maps

We present probabilistic and deterministic seismic and liquefaction hazard maps for the densely populated St. Louis metropolitan area that account for the expected effects of surficial geology on earthquake ground shaking. Hazard calculations were based on a map grid of 0.005°, or about every 500 m, and are thus higher in resolution than any earlier studies. To estimate ground motions at the surface of the model (e.g., site amplification), we used a new detailed near-surface shear-wave velocity model in a 1D equivalent- linear response analysis. When compared with the 2014 U.S. Geological Survey (USGS) National Seismic Hazard Model, which uses a uniform firm-rock-site condition, the new probabilistic seismic-hazard estimates document much more variability. Hazard levels for upland sites (consisting of bedrock and weathered bedrock overlain by loess-covered till and drift deposits), show up to twice the ground-motion values for peak ground acceleration (PGA), and similar ground-motion values for 1.0 s spectral acceleration (SA). Probabilistic ground-motion levels for lowland alluvial floodplain sites (generally the 20-40-m-thick modern Mississippi and Missouri River floodplain deposits overlying bedrock) exhibit up to twice the ground-motion levels for PGA, and up to three times the ground-motion levels for 1.0 s SA. Liquefaction probability curves were developed from available standard penetration test data assuming typical lowland and upland water table levels. A simplified liquefaction hazard map was created from the 5%-in-50-year probabilistic ground-shaking model. The liquefaction hazard ranges from low (\u3c40% of area expected to liquefy) in the uplands to severe (\u3e60% of area expected to liquefy) in the lowlands. Because many transportation routes, power and gas transmission lines, and population centers exist in or on the highly susceptible lowland alluvium, these areas in the St. Louis region are at significant potential risk from seismically induced liquefaction and associated ground deformation