Villages in Extinction and Municipal Government

Messages in this article refer to the relationship between municipal authority (“local government”) and villages in the time of their overall extinction. This work is also inspired by experience of investing too much energy illustrating the unpleasant reality of these villages, while fewer attempts have been made discovering the useful ways of managing the changes in these villages, which is given target here. Hence, this paper with its deductive approach initially sought for the principles of actions of the municipal authorities taken towards villages in extinction. Afterwards, significant space was given to the specific proposals

Associations and Return to the Farms

This paper explores the involvement of a Serbian non-government organization in solving the existential problems of "internally displaced persons and refugees“ that are temporarily residing in Serbian territory. To some extent, the participation of other entities in the activities of this organization has been explained. Based on the obtained information, an analysis of this engagement has been made. Suggestions were made regarding such activities, taking into account maintenance of the previous territorial placement of the population

A Roadmap towards Precision Periodontics

Periodontitis is among the most common health conditions and represents a major public health issue related to increasing prevalence and seriously negative socioeconomic impacts. Periodontitis-associated low-grade systemic inflammation and its pathological interplay with systemic conditions additionally raises awareness on the necessity for highly performant strategies for the prevention and management of periodontitis. Periodontal diagnosis is the backbone of a successful periodontal strategy, since prevention and treatment plans depend on the accuracy and precision of the respective diagnostics. Periodontal diagnostics is still founded on clinical and radiological parameters that provide limited therapeutic guidance due to the multifactorial complexity of periodontal pathology, which is why biomarkers have been introduced for the first time in the new classification of periodontal and peri-implant conditions as a first step towards precision periodontics. Since the driving forces of precision medicine are represented by biomarkers and machine learning algorithms, with the lack of periodontal markers validated for diagnostic use, the implementation of a precision medicine approach in periodontology remains in the very initial stage. This narrative review elaborates the unmet diagnostic needs in periodontal diagnostics, the concept of precision periodontics, periodontal biomarkers, and a roadmap toward the implementation of a precision medicine approach in periodontal practice

One solution for cross-country transport-sustainability evaluation using a modified ELECTRE method

Transport is an economic activity having complex interactions with the environment, and since the concept of sustainable development was identified as a global priority, there has been a growing interest in assessing the performance of transport systems with respect to sustainability issues. Although the Ecological Economics literature deals extensively with the strategy of sustainable development, far less attention has been paid to its application in the transport sector as of yet. The main purpose of this study was to introduce the noncompensatory analytical tool, which integrates multidimensional conditions present in the sustainability concept. The focus was on the potential of the outranking approach, namely the ELECTRE (ELimination Et Choix Traduisant la REalité; Elimination And Choice Corresponding to Reality) method for the evaluation of transport sustainability at the macro level, using the indicator set as a starting point. The method has been applied to selected European countries within a case study. As a result, according to transport-sustainability issues, pairwise relations between countries have been established. Based on these relations, and according to the chosen criteria, a set of countries with a better level of performance was selected as the core subset of the relation graph. To control and avoid the appearance of indifference relations between countries, as well as to reduce the subjectivity of decision makers, we propose a modification of ELECTRE I. Finally, we apply both the original and the modified methods, together with the sensitivity analysis. The results are presented in a convenient graph form and then compared.Sustainable-transport indicators Cross-country evaluation Outranking approach Modified ELECTRE method

Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study

Peri-implant diseases are an emerging public health problem, and it’s considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies

Incidence and clinical relevance of T(11;19) translocation in salivary gland mucoepidermoid carcinoma

Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas