Basic measurements of radiation at station Lindenberg (2013-08)

<p><b>Changes in the ratio of I</b>_<b>1524</b><b>/I</b>_<b>1151</b><b>RS bands of carotenoids during nerve exposure to pronase E</b> (A), and the rotational correlation times (τ) of DS-16 changes during nerve exposure to pronase E and methyl-β-cyclodextrin (10⁻² M) (B). Significant difference (p <0.05).</p

The dynamics of OPD profile changes along the scan-line (μM) through NR.

<p>(A); in internode region of the myelin fiber (B); the perpendicular to the normal nerve fiber and along the nerve fiber (C), during exposure of the nerve to pronase E.</p

The phase image parameters of myelin nerve fiber (1–12).

<p>(1–2)—the paranodal areas with Ranvier’s node length; (3–4)—Ranvier’s node diameter; (5–6)–diameter of nerve fiber internodal region (in incisures area); (7–8)—diameter of axon in incisures area; (9–10)—diameter of nerve fiber in internodal region; (1–12)—diameter of axon in internodal region; I—the OPD in Ranvier’s node; II—the OPD in the nerve fiber center; III- OPD in the nerve fiber boundary.</p

Raman spectra of myelin sheath of sciatic nerve fiber.

<p>Raman scattering was excited by 532-nm (A) and 780 nm (B) laser with 0.8 mW power, integration time was 50 s.</p

Study of myelin structure changes during the nerve fibers demyelination - Fig 1

<p><b>The amplitude (A) and the velocity of AP propagation (B) changes during nerve exposure to pronase E (0,2%).</b> Significant difference (p <0.05).</p

Hydration of the Carboxylate Group in Anti-Inflammatory Drugs: ATR-IR and Computational Studies of Aqueous Solution of Sodium Diclofenac

Diclofenac (active ingredient of Voltaren) has a significant, multifaceted role in medicine, pharmacy, and biochemistry. Its physical properties and impact on biomolecular structures still attract essential scientific interest. However, its interaction with water has not been described yet at the molecular level. In the present study, we shed light on the interaction between the steric hindrance (the intramolecular N–H···O bond, etc.) carboxylate group (−CO₂^–) with water. Aqueous solution of sodium declofenac is investigated using attenuated total reflection-infrared (ATR-IR) and computational approaches, i.e., classical molecular dynamics (MD) simulations and density functional theory (DFT). Our coupled classical MD simulations, DFT calculations, and ATR-IR spectroscopy results indicated that the −CO₂^– group of the diclofenac anion undergoes strong specific interactions with the water molecules. The combined experimental and theoretical techniques provide significant insights into the spectroscopic manifestation of these interactions and the structure of the hydration shell of the −CO₂^– group. Moreover, the developed methodology for the theoretical analysis of the ATR-IR spectrum could serve as a template for the future IR/Raman studies of the strong interaction between the steric hindrance −CO₂^– group of bioactive molecules with the water molecules in dilute aqueous solutions