4 research outputs found
Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts
Anilines and ethyl vinyl ether can be used as precursors
for a
process that is the synthetic equivalent of the α-arylation
of acetaldehyde enolate. The reaction manifests a high level of functional
group compatibility, allowing the ready preparation of a number of
synthetically valuable compounds
Correction to Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts
Correction to Continuous-Flow
Synthesis of Monoarylated
Acetaldehydes Using Aryldiazonium Salt
Liposomal Spherical Nucleic Acids
A novel
class of metal-free spherical nucleic acid nanostructures
was synthesized from readily available starting components. These
particles consist of 30 nm liposomal cores, composed of an FDA-approved
1,2-dioleoyl-<i>sn</i>-glycero-3-phosphoÂcholine (DOPC)
lipid monomer. The surface of the liposomes was functionalized with
DNA strands modified with a tocoÂpherol tail that intercalates
into the phosphoÂlipid layer of the liposomal core via hydrophobic
interactions. The spherical nucleic acid architecture not only stabilizes
these constructs but also facilitates cellular internalization and
gene regulation in SKOV-3 cells
Tip-Directed Synthesis of Multimetallic Nanoparticles
Alloy
nanoparticles are important in many fields, including catalysis,
plasmonics, and electronics, due to the chemical and physical properties
that arise from the interactions between their components. Typically,
alloy nanoparticles are made by solution-based synthesis; however,
scanning-probe-based methods offer the ability to make and position
such structures on surfaces with nanometer-scale resolution. In particular,
scanning probe block copolymer lithography (SPBCL), which combines
elements of block copolymer lithography with scanning probe techniques,
allows one to synthesize nanoparticles with control over particle
diameter in the 2–50 nm range. Thus far, single-element structures
have been studied in detail, but, in principle, one could make a wide
variety of multicomponent systems by controlling the composition of
the polymer ink, polymer feature size, and metal precursor concentrations.
Indeed, it is possible to use this approach to synthesize alloy nanoparticles
comprised of combinations of Au, Ag, Pd, Ni, Co, and Pt. Here, such
structures have been made with diameters deliberately tailored in
the 10–20 nm range and characterized by STEM and EDS for structural
and elemental composition. The catalytic activity of one class of
AuPd alloy nanoparticles made via this method was evaluated with respect
to the reduction of 4-nitrophenol with NaBH<sub>4</sub>. In addition
to being the first catalytic studies of particles made by SPBCL, these
proof-of-concept experiments demonstrate the potential for SPBCL as
a new method for studying the fundamental science and potential applications
of alloy nanoparticles in areas such as heterogeneous catalysis