Hydrodynamic properties of cyclodextrin molecules in dilute solutions

Three well-known representatives of the cyclodextrin family were completely characterized by molecular hydrodynamics methods in three different solvents. For the first time the possibility of an estimation of velocity sedimentation coefficients s between 0.15 and 0.5 S by the numerical solution of the Lamm equation is shown. Comparison of the experimental hydrodynamic characteristics of the cyclodextrins with theoretical calculations for toroidal molecules allows an estimation of the thickness of the solvent layers on the surface of cyclodextrin molecules

Обзор исследований по городской среде Красноярска

An article gives a review of the scientific literature on the urban environment in Krasnoyarsk, defines main areas of research of this topic, provides analysis of representative scientific publications reflecting the fixation of characteristics and describing the dynamic change of the environment. The result was an examination of more than 50 sources, including applied projects and the results of surveys of citizens and experts. The application of the research results is a study within the framework of the RFBR project on urban transformations in Krasnoyarsk since 1990–2010. The author makes a conclusion that modern studies of Krasnoyarsk have been carried out in the following areas: the diagnostics to determine the level of city’s ecological state; monitoring public opinion; research on the causes of migration of educated youth, as well as aesthetic criticism of the territory; cataloging the historical, cultural and architectural heritage objects; discussing city planning and the problems of this plan implementation, as well as the problems of the general mobility of citizens, including the accessibility of the urban environment for persons with reduced mobility. Moreover, the article draws attention to the city planning concept of the “garden city” as an embodiment of the synthesis of social, aesthetic and green intentions of societyОбзор научной литературы по городской среде города Красноярска проводится с определением основных направлений исследования данной темы, анализом репрезентативных научных публикаций, отражающих фиксацию характеристик и динамику изменения среды. Результатом стал анализ свыше 50 источников, включая прикладные проекты и результаты опросов жителей и экспертов. Областью применения результатов статьи является исследование в рамках проекта РФФИ по городским трансформациям Красноярска с 1990-х по 2010-е гг. В результате определено, что современные исследования Красноярска проходят по следующим направлениям: результаты диагностики по определению уровня экологической благополучности города, мониторинги общественного мнения и исследования причин миграций образованной молодежи, а также эстетическая критика территории, каталогизация историко-культурного и архитектурного наследия, обсуждения градостроительного плана и проблемы его воплощения, а также проблем всеобщей мобильности горожан, включая доступность городской среды для маломобильных граждан. Более того, в статье обращается внимание на градостроительный замысел «города-сада» как на воплощение синтеза социальных, эстетических и экологических интенций обществ

Отношения человека и мира в пейзажах Б.Я. Ряузова

This paper analyzes the relationship of man and the world in the picturesque landscapes of the Krasnoyarsk painter B.Ia. Riauzov. The authors consider two basic philosophical issues, reflected in the work of the Siberian artist, i.e. conflict between “nature” (also first nature) and “culture” (second, man-made nature), idyllic relationship between man and the worldВ данной статье анализируется отношение человека и мира в живописном творчестве красноярского пейзажиста Б.Я. Ряузова. Авторы рассматривают две основные мировоззренческие проблемы, отраженные в творчестве сибирского художника: конфликт «натуры» (первой природы) и «культуры» (второй природы, созданной человеком), идиллия отношения человека и мир

Отношения человека и мира в пейзажах Б.Я. Ряузова

This paper analyzes the relationship of man and the world in the picturesque landscapes of the Krasnoyarsk painter B.Ia. Riauzov. The authors consider two basic philosophical issues, reflected in the work of the Siberian artist, i.e. conflict between “nature” (also first nature) and “culture” (second, man-made nature), idyllic relationship between man and the worldВ данной статье анализируется отношение человека и мира в живописном творчестве красноярского пейзажиста Б.Я. Ряузова. Авторы рассматривают две основные мировоззренческие проблемы, отраженные в творчестве сибирского художника: конфликт «натуры» (первой природы) и «культуры» (второй природы, созданной человеком), идиллия отношения человека и мир

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)