Evidence for pseudogap and phase-coherence gap separation by Andreev reflection experiments in Au/La_{2-x}Sr_{x}CuO_4 point-contact junctions

We present new Au/La_{2-x}Sr_{x}CuO_{4} (LSCO) point-contact conductance measures as a function of voltage and temperature in samples with 0.08 <= x <= 0.2. Andreev reflection features disappear at about the bulk Tc, giving no evidence of gap for T > Tc. The fit of the normalized conductance at any T < Tc supports a (s + d)-wave symmetry of the gap, whose dominant low-T s component follows the Tc(x) curve in contrast with recent angle-resolved photoemission spectroscopy and quasiparticle tunneling data. These results prove the separation between pseudogap and phase-coherence superconducting gap in LSCO at x <= 0.2.Comment: 4 pages, 4 eps figures, 1 table (RevTeX). Labels added to Fig. 1; Fig. 3 resized; references added; short discussion about ballistic contact regime adde

A representation of robotic behaviors using component port arbitration

Presented at DSLRob 2014 (arXiv:cs/1411.7148)Developing applications considering reactiveness, scalability and re-usability has always been at the center of attention of robotic researchers. Behavior-based architectures have been proposed as a programming paradigm to develop robust and complex behaviors as integration of simpler modules whose activities are directly modulated by sensory feedback or input from other models. The design of behavior based systems, however, becomes increasingly difficult as the complexity of the application grows. This article proposes an approach for modeling and coordinating behaviors in distributed architectures based on port arbitration which clearly separates representation of the behaviors from the composition of the software components. Therefore, based on different behavioral descriptions, the same software components can be reused to implement different applications

A novel CMB polarization likelihood package for large angular scales built from combined WMAP and Planck LFI legacy maps

We present a CMB large-scale polarization dataset obtained by combining WMAP Ka, Q and V with Planck 70 GHz maps. We employ the legacy frequency maps released by the WMAP and Planck collaborations and perform our own Galactic foreground mitigation technique, which relies on Planck 353 GHz for polarized dust and on Planck 30 GHz and WMAP K for polarized synchrotron. We derive a single, optimally-noise-weighted, low-residual-foreground map and the accompanying noise covariance matrix. These are shown, through $\chi^2$ analysis, to be robust over an ample collection of Galactic masks. We use this dataset, along with the Planck legacy Commander temperature solution, to build a pixel-based low-resolution CMB likelihood package, whose robustness we test extensively with the aid of simulations, finding excellent consistency. Using this likelihood package alone, we constrain the optical depth to reionazation $\tau=0.069^{+0.011}_{-0.012}$ at $68\%$ C.L., on 54\% of the sky. Adding the Planck high-$\ell$ temperature and polarization legacy likelihood, the Planck lensing likelihood and BAO observations we find $\tau=0.0714_{-0.0096}^{+0.0087}$ in a full $\Lambda$CDM exploration. The latter bounds are slightly less constraining than those obtained employing \Planck\ HFI CMB data for large angle polarization, that only include EE correlations. Our bounds are based on a largely independent dataset that does include also TE correlations. They are generally well compatible with Planck HFI preferring slightly higher values of $\tau$. We make the low-resolution Planck and WMAP joint dataset publicly available along with the accompanying likelihood code.Comment: The WMAP+LFI likelihood module is available on \http://www.fe.infn.it/u/pagano/low_ell_datasets/wmap_lfi_legacy

Design and Implementation of a YARP Device Driver Interface: The Depth-Sensor Case

This work illustrates the design phases leading to the development of a new YARP device interface along with its client/server implementation. In order to obtain a smoother integration and a more reliable software usability, while avoiding common errors during the design phases, a new interface is created in the YARP network when a new family of devices is introduced

Eradication of Candida albicans persister cell biofilm by the membranotropic peptide gH625

Biofilm formation poses an important clinical trouble due to resistance to antimicrobial agents; therefore, there is an urgent demand for new antibiofilm strategies that focus on the use of alternative compounds also in combination with conventional drugs. Drug-tolerant persisters are present in Candida albicans biofilms and are detected following treatment with high doses of amphotericin B. In this study, persisters were found in biofilms treated with amphotericin B of two clinical isolate strains, and were capable to form a new biofilm in situ. We investigated the possibility of eradicating persister-derived biofilms from these two Candida albicans strains, using the peptide gH625 analogue (gH625-M). Confocal microscopy studies allowed us to characterize the persister-derived biofilm and understand the mechanism of interaction of gH625-M with the biofilm. These findings confirm that persisters may be responsible for Candida biofilm survival, and prove that gH625-M was very effective in eradicating persister-derived biofilms both alone and in combination with conventional antifungals, mainly strengthening the antibiofilm activity of fluconazole and 5-flucytosine. Our strategy advances our insights into the development of effective antibiofilm therapeutic approaches

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ

Nucleophosmin (NPM1) is a multifunctional nucleolar protein implicated in ribogenesis, centrosome duplication, cell cycle control, regulation of DNA repair and apoptotic response to stress stimuli. The majority of these functions are played through the interactions with a variety of protein partners. NPM1 is frequently overexpressed in solid tumors of different histological origin. Furthermore NPM1 is the most frequently mutated protein in acute myeloid leukemia (AML) patients. Mutations map to the C-terminal domain and lead to the aberrant and stable localization of the protein in the cytoplasm of leukemic blasts. Among NPM1 protein partners, a pivotal role is played by the tumor suppressor Fbw7γ, an E3-ubiquitin ligase that degrades oncoproteins like c-MYC, cyclin E, Notch and c-jun. In AML with NPM1 mutations, Fbw7γ is degraded following its abnormal cytosolic delocalization by mutated NPM1. This mechanism also applies to other tumor suppressors and it has been suggested that it may play a key role in leukemogenesis. Here we analyse the interaction between NPM1 and Fbw7γ, by identifying the protein surfaces implicated in recognition and key aminoacids involved. Based on the results of computational methods, we propose a structural model for the interaction, which is substantiated by experimental findings on several site-directed mutants. We also extend the analysis to two other NPM1 partners (HIV Tat and CENP-W) and conclude that NPM1 uses the same molecular surface as a platform for recognizing different protein partners. We suggest that this region of NPM1 may be targeted for cancer treatment

Gaze Stabilization for Humanoid Robots: a Comprehensive Framework

6 pages, appears in 2014 IEEE-RAS International Conference on Humanoid RobotsGaze stabilization is an important requisite for humanoid robots. Previous work on this topic has focused on the integration of inertial and visual information. Little attention has been given to a third component, which is the knowledge that the robot has about its own movement. In this work we propose a comprehensive framework for gaze stabilization in a humanoid robot. We focus on the problem of compensating for disturbances induced in the cameras due to self-generated movements of the robot. In this work we employ two separate signals for stabilization: (1) an anticipatory term obtained from the velocity commands sent to the joints while the robot moves autonomously; (2) a feedback term from the on board gyroscope, which compensates unpredicted external disturbances. We first provide the mathematical formulation to derive the forward and the differential kinematics of the fixation point of the stereo system. We finally test our method on the iCub robot. We show that the stabilization consistently reduces the residual optical flow during the movement of the robot and in presence of external disturbances. We also demonstrate that proper integration of the neck DoF is crucial to achieve correct stabilization

Enhancing software module reusability using port plug-ins: an experiment with the iCub robot

Published on the Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2014)Systematically developing high--quality reusable software components is a difficult task and requires careful design to find a proper balance between potential reuse, functionalities and ease of implementation. Extendibility is an important property for software which helps to reduce cost of development and significantly boosts its reusability. This work introduces an approach to enhance components reusability by extending their functionalities using plug-ins at the level of the connection points (ports). Application--dependent functionalities such as data monitoring and arbitration can be implemented using a conventional scripting language and plugged into the ports of components. The main advantage of our approach is that it avoids to introduce application--dependent modifications to existing components, thus reducing development time and fostering the development of simpler and therefore more reusable components. Another advantage of our approach is that it reduces communication and deployment overheads as extra functionalities can be added without introducing additional modules