478 research outputs found
Fractional quantum Hall states as an Abelian group
We show that the set of double-layer Fractional Quantum Hall (FQH) states
with a given topological order form a finite Abelian group under a new product.
This group structure makes it possible to construct new FQH states from known
ones. We also introduce a new index which can be used to characterize the
topological order of FQH states.Comment: 9 page
Generalized Uncertainty Principle as a Consequence of the Effective Field Theory
We will demonstrate that the generalized uncertainty principle exists because
of the derivative expansion in the effective field theories. This is because,
in the framework of the effective field theories, the minimum measurable length
scale has to be integrated away to obtain the low energy effective action. We
will analyze the deformation of a massive free scalar field theory by the
generalized uncertainty principle, and demonstrate that the minimum measurable
length scale corresponds to a second more massive scale in the theory, which
has been integrated away. We will also analyze CFT operators dual to this
deformed scalar field theory, and observe that scaling of the new CFT operators
indicates that they are dual to this more massive scale in the theory. We will
use holographic renormalization to explicitly calculate the renormalized
boundary action with counterterms for this scalar field theory deformed by the
generalized uncertainty principle and show that the generalized uncertainty
principle contributes to the matter conformal anomaly.Comment: 15 pages, no figures, Accepted for Publication in Physics Letters
Aspects of moduli stabilization in type IIB string theory
We review moduli stabilization in type IIB string theory compactification
with fluxes. We focus on the KKLT and Large Volume Scenario (LVS). We show that
the predicted soft SUSY breaking terms in KKLT model are not phenomenological
viable. In LVS, the following result for scalar mass, gaugino mass, and
trilinear term is obtained: , which may account
for Higgs mass limit if TeV. However, in this case
the relic abundance of the lightest neutralino can not be consistent with the
measured limits. We also study the cosmological consequences of moduli
stabilization in both models. In particular, the associated inflation models
such as racetrack inflation and K\"ahler inflation are analyzed. Finally the
problem of moduli destabilization and the effect of string moduli backreaction
on the inflation models are discussed.Comment: 34 pages, 8 figure
Characterization of aggresome formation in choroid plexus carcinoma.
Protein misfolding is inevitable, 30% of newly synthesized polypeptides can end up misfolded, and such proteins are either refolded or eliminated by cellular quality control pathways. These pathways include the ubiquitin proteosome system and autophagy. In recent years, protein misfolding has been implicated in the pathophysiology of many diseases such as diabetes, neurological disorders and cancer. Studies from our laboratory have shown that choroid plexus carcinoma tumors are characterized by the formation of aggresomes at the microtubules organizing centers (MTOC) in formalin fixed and paraffin embedded (FFPE) tumor tissues. This was further confirmed by the development of choroid plexus carcinoma cell line (CCHE-45) which was characterized by the constitutive formation of aggresomes at MTOC. Aggresome formation implies presence of toxic protein over load and/or defective autophagy. The role of autophagic flux in the removal of aggresomes was further investigated. CCHE-45 cells displayed an increase in both basal and induced autophagic flux. Furthermore, microtubule-associated protein light chain 3 A- variant 1 (LC3A-V1) expression was silenced by promoter methylation in these cells. Restoring LC3A-V1 resulted in the elimination of the aggresomes and the recruitment of Lysosomal-Associated Membrane Protein (LAMP2) independent from autophagosome formation. Based on these findings we suggest that quality control autophagy in CCHE-45 is mediated by LC3A in aggresomes clearance. We propose that perturbation in the autophagic pathway by the absence of LC3A expression leads to a failure in aggresome degradation thus overcoming misfolded protein overload
Factors Affecting the Implementation of Electronic Medical Records Systems (EMRs) in Jordanian Hospitals
An Electronic Medical Record System (EMRS) is an application that enables access and retrieval of a patient's medical history. Currently EMRS implementation does not encompass more than 50% of the hospitals in Jordan, and limited research has been done in Jordan to identify the main factors affecting the implementation of EMRS. The aim of this study is to explore the factors that affect the EMRS implementation in Jordanian hospitals. A conceptual model, adapted from Technology Acceptance Model (TAM), was built to relate Organizational Factors (OF) and Individual Characteristic Factors (ICF) to EMRS implementation in Jordanian hospitals. Self-administered questionnaires were used to collect the data from healthcare professionals in two major hospitals that have full implementation of EMRS. Findings indicated that OF has significant relationships with Perceived Ease of Use (PEOU) and Perceived Usefulness (PU), ICF has significant relationships with PEOU, User-Patient relationship has significant relationships with PU with exception of User Autonomy, PEOU has a significant effects with PU, PU has significant relationship with Attitude Toward Using (ATU) exception of PEOU, and ATU has a significant relationship with Behavioural Intention to Use. The finding of this study has led to the enhancement of the theoretical knowledge of TAM'S application in the health informatics domain. This study has extended the current model comprising PEOU and PU, by adding the OF and ICF. Consequently, the findings can assist decision makers in formulating EMRS implementation strategies in Jordan
Kienböck’s disease: a case report
Kienböck disease is a condition characterized by avascular necrosis of the lunate bone. Advanced imaging can aid in the diagnosis and staging of Kienböck disease. Magnetic resonance imaging (MRI) is an important adjunct to diagnosis. In particular, MRI is helpful early in the disease when plain radiographs may not reveal abnormalities. A 17 -year-old man with Kienböck disease who underwent radiography and MR is described in this article.Pan African Medical Journal 2015; 2
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