Influence of Incomplete Fusion Reaction on Complete Fusion Below 10 Mev/ Nucleon Energies

An attempt has been made in the present work to provide an ample opportunity to explore the information about the influence of incomplete fusion (ICF) reaction dynamics on complete fusion in heavy ion induced nuclear reactions. excitation functions for several evaporation residues produced in the interaction of projectile 16O with target 175lu have been measured over the wide projectile energy range ≈ 70-100 MeV. the recoil-catcher activation technique followed by the offline γ-ray spectroscopy has been used for the present measurements. In case of precursor decay, we have made use of Cavinato et al. formulation to calculate the independent cross-section of the identified residues. the measured efs are compared with theoretical predictions of statistical model code PACE-2 and any enhancement in the measured cross-section from theoretical prediction may be due to ICF reaction process. An attempt has been made to estimate the ICf contribution of the cross-section from the measured excitation function data and the dependence of ICf cross-section on projectile energy

ECG Wavelet Analysis for the Detection of Gene Mutations in Patients with Brugada Syndrome

Abstract We applied wavelet transform (WT) Introduction The Brugada syndrome (BrS) is an inherited ion chanelopathy characterised by a typical electrocardiographic (ECG) pattern of J point and ST segment elevation in the right precordial leads and predisposition towards malignant ventricular arrhythmias Both depolarisation and repolarisation abnormalities contribute to the arrhythmia substrate and arrhythmia genesis in the BrS Wavelet analysis is a form of time-frequency transformation that has long been used in non-invasive electrocardiology for detection of characteristic ECG components, heart rate variability, analysis of ischaemic ST changes, ventricular repolarisation and others In this study, we hypothesised that continuous wavelet transform (WT) applied to the QRS and ST-T wave can help to identify carriers of SCN5A mutations among patients with the BrS. We analysed digital 15-lead ECGs previously recorded during positive diagnostic ajmaline test for BrS with simultaneous acquisition of the right precordial leads in both standard, as well as "high" electrode positions. Methods Study population and data acquisition The study population consisted of 26 patients (age 42.0±17.8 years, 13 men, 13 women, age 41.6±19.1 and 42.4±17.2, respectively, p=0.92 for men vs women) with suspected BrS who underwent diagnostic ajmaline test as part of their standard clinical management. All patients had either normal or non-diagnostic (i.e. not displaying type 1 Brugada ECG pattern) resting ECGs before the test. Details about this patient population have been partially described in previous publication

Comparative expression profiling and sequence characterization of ATP1A1 gene associated with heat tolerance in tropically adapted cattle

Climate change is an imminent threat to livestock production. One adaptation strategy is selection for heat tolerance. While it is established that the ATP1A1 gene and its product play an important role in the response to many stressors, there has been no attempt to characterize the sequence or to perform expression profiling of the gene in production animals. We undertook a field experiment to compare the expression profiles of ATP1A1 in heat-tolerant Vechur and Kasaragod cattle (Bos taurus indicus) with the profile of a heat-susceptible crossbreed (B. t. taurus × B. t. indicus). The cattle were exposed to heat stress while on pasture in the hot summer season. The environmental stress was quantified using the temperature humidity index (THI), while the heat tolerance of each breed was assessed using a heat tolerance coefficient (HTC). The ATP1A1 mRNA of Vechur cattle was amplified from cDNA and sequenced. The HTC varied significantly between the breeds and with time-of-day (p < 0.01). The breed–time-of-day interaction was also significant (p < 0.01). The relative expression of ATP1A1 differed between heat-tolerant and heat-susceptible breeds (p = 0.02). The expression of ATP1A1 at 08:00, 10:00 and 12:00, and the breed–time-of-day interaction, were not significant. The nucleotide sequence of Vechur ATP1A1 showed 99% homology with the B. t. taurus sequence. The protein sequence showed 98% homology with B. t. taurus cattle and with B. grunniens (yak) and 97.7% homology with Ovis aries (sheep). A molecular clock analysis revealed evidence of divergent adaptive evolution of the ATP1A1 gene favoring climate resilience in Vechur cattle. These findings further our knowledge of the relationship between the ATP1A1 gene and heat tolerance in phenotypically incongruent animals. We propose that ATP1A1 could be used in marker assisted selection (MAS) for heat tolerance

The effects of thermal capsulorrhaphy of medial parapatellar capsule on patellar lateral displacement

<p>Abstract</p> <p>Background</p> <p>The effectiveness of thermal shrinkage on the medial parapatellar capsule for treating recurrent patellar dislocation is controversial. One of reasons why it is still controversial is that the effectiveness is still qualitatively measured. The purpose of this study was to quantitatively determine the immediate effectiveness of the medial parapatellar capsule shrinkage as in clinical setting.</p> <p>Methods</p> <p>Nine cadaveric knees were used to collect lateral displacement data before and after medial shrinkage or open surgery. The force and displacement were recorded while a physician pressed the patella from the medial side to mimic the physical exam used in clinic. Ten healthy subjects were used to test the feasibility of the technique on patients and establish normal range of lateral displacement of the patella under a medial force. The force applied, the resulting displacement and the ratio of force over displacement were compared among four data groups (normal knees, cadaveric knees before medial shrinkage, after shrinkage and after open surgery).</p> <p>Results</p> <p>Displacements of the cadaveric knees both before and after thermal modification were similar to normal subjects, and the applied forces were significantly higher. No significant differences were found between before and after thermal modification groups. After open surgery, displacements were reduced significantly while applied forces were significantly higher.</p> <p>Conclusion</p> <p>No immediate difference was found after thermal shrinkage of the medial parapatellar capsule. Open surgery immediately improved of the lateral stiffness of the knee capsule.</p

An Evaluation of the Antioxidant Activity of a Methanolic Extract of Cucumis melo L. Fruit (F1 Hybrid)

Cucumis melo L. (C. melo) is a fruit with many medicinal properties and is consumed in various countries. It is utilised for chronic eczema and to treat minor burns and scrapes. The present study was conducted to evaluate the antioxidant activity of a methanolic extract of Cucumis melo Linn (MECM). A coarse powder prepared from the fruit and seeds was extracted with methanol (absolute) by a hot continuous percolation process in accordance with the standard protocols. All the extracts were estimated for potential antioxidant activities with tests such as an estimation of total antioxidant activity, hydroxyl radical and nitric oxide scavenging activity and reducing power ability. The qualitative analysis of the methanolic extract of C. melo fruit showed the presence of various phytochemical constituents such as carbohydrates, alkaloids, sterols, phenolic compounds, terpenes and flavonoids. The total antioxidant activity of concentrations of 50, 100 and 200 µg were tested and observed to be 3.3 ± 0.1732, 6.867 ± 0.5457 and 13.63 ± 0.8295 µg of ascorbic acid, respectively. The results also showed significant nitric oxide and DPPH scavenging activities as well as a reducing power activity of MECM. Thus, our results suggest that MECM may serve as a putative source of natural antioxidants for therapeutic and nutraceutical applications

Study of break-up fusion process from forward recoil range distribution measurement

540-543In the present work, the break-up fusion or incomplete fusion (ICF) process has been studied from the forward recoil range distribution measurement for 16O + 175Lu system at ≈ 96 MeV energy. The measured forward recoil range distributions are analyzed in the framework of code SRIM. The present analysis shows clearly the role of linear momentum transfer and also the break-up of projectile 16O into its fragments (12C + 4He and/or 8Be + 8Be). Any systematic trend is not observed with the target deformation parameter (β2) dependent study of ICF. It is observed that projectile structure also affects the ICF dynamics. The projectile α-Q-value is found to be a suitable parameter which explains effectively the observed projectile structure effect on ICF

Comparative Expression Profiling and Sequence Characterization of ATP1A1 Gene Associated with Heat Tolerance in Tropically Adapted Cattle

Climate change is an imminent threat to livestock production. One adaptation strategy is selection for heat tolerance. While it is established that the ATP1A1 gene and its product play an important role in the response to many stressors, there has been no attempt to characterize the sequence or to perform expression profiling of the gene in production animals. We undertook a field experiment to compare the expression profiles of ATP1A1 in heat-tolerant Vechur and Kasaragod cattle (Bos taurus indicus) with the profile of a heat-susceptible crossbreed (B. t. taurus × B. t. indicus). The cattle were exposed to heat stress while on pasture in the hot summer season. The environmental stress was quantified using the temperature humidity index (THI), while the heat tolerance of each breed was assessed using a heat tolerance coefficient (HTC). The ATP1A1 mRNA of Vechur cattle was amplified from cDNA and sequenced. The HTC varied significantly between the breeds and with time-of-day (p &lt; 0.01). The breed–time-of-day interaction was also significant (p &lt; 0.01). The relative expression of ATP1A1 differed between heat-tolerant and heat-susceptible breeds (p = 0.02). The expression of ATP1A1 at 08:00, 10:00 and 12:00, and the breed–time-of-day interaction, were not significant. The nucleotide sequence of Vechur ATP1A1 showed 99% homology with the B. t. taurus sequence. The protein sequence showed 98% homology with B. t. taurus cattle and with B. grunniens (yak) and 97.7% homology with Ovis aries (sheep). A molecular clock analysis revealed evidence of divergent adaptive evolution of the ATP1A1 gene favoring climate resilience in Vechur cattle. These findings further our knowledge of the relationship between the ATP1A1 gene and heat tolerance in phenotypically incongruent animals. We propose that ATP1A1 could be used in marker assisted selection (MAS) for heat tolerance