7 research outputs found
Evaluation of patients’ experiences at different stages of the intravitreal injection procedure – what can be improved?
Identification of candidate protective variants for common diseases and evaluation of their protective potential
Additional file 2: Table S2. of Identification of candidate protective variants for common diseases and evaluation of their protective potential
Comparison of methods (PolyPhen-2 and CADD) to predict functional effect of CPVs. (DOCX 92 kb
Additional file 1: Table S1. of Identification of candidate protective variants for common diseases and evaluation of their protective potential
Summary of filtering stages performed on GWAS catalog. (DOCX 59 kb
Recommendations by a UK expert panel on an aflibercept treat-and-extend pathway for the treatment of neovascular age-related macular degeneration
Study protocol on prevalence of non-exudative macular neovascularisation and its contribution to prediction of exudation in fellow eyes with unilateral exudative AMD (EYE-NEON)
Abstract
Purpose
Fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) are at risk of developing macular neovascularisation (MNV). These eyes may first develop subclinical non-exudative MNV (neMNV) before they leak to form exudative MNV (eMNV). The EYE NEON study is a 2-year study aimed at estimating the prevalence and incidence of neMNV and evaluating its role as a predictor for conversion to neovascular AMD.
Methods
EYE NEON is a multicentre study that will run in retinal clinics across 25 National Health Service with the aim to recruit 800 patients with new onset nAMD in the first eye. The fellow-eye with no evidence of nAMD at baseline will be the study eye. All study eyes will have OCT and OCTA done at first and second year following first anti-VEGF treatment to the first eye (non-study eye), with new onset nAMD. We will estimate the prevalence and incidence of neMNV over 2 years, rate of conversion from neMNV to eMNV and numbers initiated on treatment for neovascular AMD in the study eye will be reported. Predictive models of conversion including neMNV with other demographic and imaging parameters will be developed.
Conclusion
The study design with proposed target sample size is sufficient to evaluate the retinal imaging characteristics of the study eyes with and without neMNV and develop predictive models to inform risk of conversion to nAMD.
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