Total Synthesis of (−)-α-Kainic acid via Chirality Transfer through Ireland–Claisen Rearrangement

The total synthesis of (−)-α- Kainic acid is accomplished using a linear strategy involving Noyori asymmetric reduction and chirality transfer through Ireland–Claisen rearrangement as key steps

Formal Synthesis of Antiplatelet Drug, Beraprost

The first stereocontrolled and enantiospecific formal synthesis of antiplatelet drug beraprost has been achieved from readily available 1-tetralone

Asymmetric Roadmap to Diverse Polycyclic Benzopyrans via Phosphine-Catalyzed Enantioselective [4 + 2]-Annulation Reaction

The catalytic addition of the amino acid derived bifunctional <i>N</i>-acylamino­phosphine to an α-substituted allene ester generated a zwitterionic dipole that engaged the vinylogous ester function of 3-cyano-chromones in a [4 + 2] annulation reaction to deliver tetrahydroxanthones embodying three consecutive chiral centers in high yields and with excellent enantioselectivities. The established asymmetric synthesis further paves the way to two different classes of complex, sp³-rich tetracyclic benzopyrans via efficient cascade reactions