Analysis of Process Parameters of Fused Deposition Modeling (FDM) Technique

Fused deposition modeling (FDM) is one of the RP technique in which a plastic filament is melted in the extruder of the 3D printer and deposited on the build platform of the 3D printer to form the object layer by layer. Part quality and mechanical properties of the FDM fabricated parts extensively depends on process variable parameters such as layer thickness, raster angle, part orientation, raster width, air gap. Hence, selection and optimization of FDM process parameters is vital. The aim and objective of this article is to study and determine the influence of these parameters on processed part through the research work carried out so far. A number of optimization techniques and designs of experiments for the determination of optimum process parameter have been studied

Effect of dietary palm olein oil on oxidative stress associated with ischemic-reperfusion injury in isolated rat heart

BACKGROUND: Palm olein oil (PO), obtained from refining of palm oil is rich in monounsaturated fatty acid and antioxidant vitamins and is widely used as oil in diet in many parts of the world including India. Palm oil has been reported to have beneficial effects in oxidative stress associated with hypertension and arterial thrombosis. Oxidative stress plays a major role in the etiopathology of myocardial ischemic-reperfusion injury (IRI) which is a common sequel of ischemic heart disease. Antioxidants have potent therapeutic effects on both ischemic heart disease and ischemic-reperfusion injury. Information on the effect of PO on ischemic-reperfusion injury is, however, lacking. In the present study, the effect of dietary palm olein oil on oxidative stress associated with IRI was investigated in an isolated rat heart model. Wistar rats (150–200 gm) of either sex were divided into three different groups (n = 16). Rats were fed with palm olein oil supplemented commercial rat diet, in two different doses [5% v / w (PO 5) and 10% v / w (PO 10) of diet] for 30 days. Control rats (C) were fed with normal diet. After 30 days, half the rats from each group were subjected to in vitro myocardial IRI (20 min of global ischemia, followed by 40 min of reperfusion). Hearts from all the groups were then processed for biochemical and histopathological studies. One way ANOVA followed by Bonferroni test was applied to test for significance and values are expressed as mean ± SE (p < 0.05). RESULTS: There was a significant increase in myocardial catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities with no significant change in myocardial thiobarbituric acid reactive substances (TBARS) only in group PO 5 as compared to group C. There was no light microscopic evidence of tissue injury. A significant rise in myocardial TBARS and depletion of myocardial endogenous antioxidants (SOD, CAT and GPx) along with significant myocyte injury was observed in control rats subjected to ischemia-reperfusion (C IR). Hearts from palm olein oil fed rats subjected to ischemia-reperfusion (PO 5 IR and PO 10 IR) were protected from increase in TBARS and depletion of endogenous antioxidants as compared to C IR group. No significant myocyte injury was present in the treated groups. CONCLUSIONS: The present study demonstrated for the first time that dietary palm olein oil protected rat heart from oxidative stress associated with ischemic-reperfusion injury

Daksha: On Alert for High Energy Transients

We present Daksha, a proposed high energy transients mission for the study of electromagnetic counterparts of gravitational wave sources, and gamma ray bursts. Daksha will comprise of two satellites in low earth equatorial orbits, on opposite sides of earth. Each satellite will carry three types of detectors to cover the entire sky in an energy range from 1 keV to >1 MeV. Any transients detected on-board will be announced publicly within minutes of discovery. All photon data will be downloaded in ground station passes to obtain source positions, spectra, and light curves. In addition, Daksha will address a wide range of science cases including monitoring X-ray pulsars, studies of magnetars, solar flares, searches for fast radio burst counterparts, routine monitoring of bright persistent high energy sources, terrestrial gamma-ray flashes, and probing primordial black hole abundances through lensing. In this paper, we discuss the technical capabilities of Daksha, while the detailed science case is discussed in a separate paper.Comment: 9 pages, 3 figures, 1 table. Additional information about the mission is available at https://www.dakshasat.in

Science with the Daksha High Energy Transients Mission

We present the science case for the proposed Daksha high energy transients mission. Daksha will comprise of two satellites covering the entire sky from 1~keV to $>1$~MeV. The primary objectives of the mission are to discover and characterize electromagnetic counterparts to gravitational wave source; and to study Gamma Ray Bursts (GRBs). Daksha is a versatile all-sky monitor that can address a wide variety of science cases. With its broadband spectral response, high sensitivity, and continuous all-sky coverage, it will discover fainter and rarer sources than any other existing or proposed mission. Daksha can make key strides in GRB research with polarization studies, prompt soft spectroscopy, and fine time-resolved spectral studies. Daksha will provide continuous monitoring of X-ray pulsars. It will detect magnetar outbursts and high energy counterparts to Fast Radio Bursts. Using Earth occultation to measure source fluxes, the two satellites together will obtain daily flux measurements of bright hard X-ray sources including active galactic nuclei, X-ray binaries, and slow transients like Novae. Correlation studies between the two satellites can be used to probe primordial black holes through lensing. Daksha will have a set of detectors continuously pointing towards the Sun, providing excellent hard X-ray monitoring data. Closer to home, the high sensitivity and time resolution of Daksha can be leveraged for the characterization of Terrestrial Gamma-ray Flashes.Comment: 19 pages, 7 figures. Submitted to ApJ. More details about the mission at https://www.dakshasat.in

Axiomatics : the apparatus of capitalism

The thesis critically appropriates the collaborative philosophy of Gilles Deleuze and Félix Guattari to argue that the general tendency of capitalism is towards the disintegration of high-level control structures (for instance, the nation-state). This disintegration does not entail a movement towards total chaos or anarchy. I argue that capital generates its own guidance mechanisms, but ones that act at a low-level, and respond flexibly to changing conditions (an instance of micro-politics). One of the difficulties of this project stems from the fact that the canon of philosophical discourse itself operates as a high-level control structure. In Marx, the development of capital is controlled by a secularized Hegelian dialectic that determines the outcome of capital in socialism. For Freud, the low level organization of the unconscious is subjected to high-level control through the universality of the Oedipus complex. By addressing the need for new philosophical instruments to understand capitalism, the thesis produces critiques of Marx and Freud, and advances a philosophy of economics by examining the function of axiomatics. Moreover, in critiquing presupposed structures (for example, the unconscious as a theatre of representation), the thesis argues for an immanent system (mulliplicity) of interaction within capitalism. The research undertaken to complete the thesis has consisted of contemporary experiments in complexity theory, and current socio/economic analyses of labour markets. Of particular interest has been the current deindustrialization that has taken place in the west coast of the United States. With the influx of a periphery into the core area of Los Angeles, the current role of urban politics and minor literatures (most notably Shakur's autobiography) unleash desire into the circuit of the city. I conclude with a re-examination of micro political/economic movements that have manifested themselves into the economy of Los Angeles. By decoding locally impoverished economic and cultural sectors, emergent properties have sprouted by realigning subversive activity onto the apex of capital (an immanence to capitalist processes)

Concepts of dentistry as quoted in Indian system of medicine

This article deals about various concepts of dentistry as quoted in Indian system of medicine

Antihypertensives in oral submucous fibrosis

Oral submucous fibrosis is a common pre-malignant condition affecting the oral mucosa with more prevalence among Indian population. Various treatment modalities have been elucidated in order to alleviate the symptoms associated with OSMF. Currently oral Anti-hypertensive has been proved to have beneficial result in treating OSMF because of its anti-inflammatory, fibrinolytic, immunomodulatory and rheologic modifying property. Several categories of drugs have been used in the treatment of OSMF but their effectiveness leaves much to be desired and no treatment regimen has afforded definitive cure. While Oral administration limits the concentration of drugs in lesional tissue and increases the potential for side effects, the Intralesional injections are associated with significant mechanical injury and noncompliance on the patient’s part because of the accompanying discomfort and pain. The present study was done to evaluate the effectiveness of oral antihypertensives in the management of OSMF.&nbsp; Very few studies across world have showed that anti-hypertensive drugs showed significant improvement in mouth opening, reduction in burning sensation. Hence anti-hypertensive can be a good alternative in the management of OSMF for whom intralesional steroids or hyaluronidase are contraindicated, for those who cannot make frequent visit and to avoid pain due to injection

Infection control in dentistry: A review

Infection control is important in the practice of dentistry because dental healthcare workers and patients are exposed to e wide variety of microorganisms through blood and oral secretions. A long history of scientific, clinical and technological developments has led to the current recommendations for infection control in dentistry and medicine. As a result, health care workers and their patients have never been protected from occupational transmission of pathogens. Engineering and re-emerging infection control challenges will continue to confront the health profession in the 21st century. In addition, procedures aimed at preventing the spread of infectious disease are constantly being evaluated and updated. Among the important components of any infection control success, however, always will be remembering and understanding the rationale for appropriate practices. The routine applications of precautions such as multiple aseptic procedures, latex gloves, masks, protective eyewear, clinic coats, automated instrument decontamination devices, time-efficient heat sterilization modalities, chemical disinfectants, waste management procedures and single-use disposable items have created a safer environment for dental personal and patients alike. Hence the review aimed at stressing the importance of sterilization and disinfection in dental practic