Polynomial Based Dynamic Key Management for Secure Cluster Communication in Wireless Mobile Sensor Network

For inter and intra cluster communication, member nodes jointly build a mutual session key called cluster key to allow secure communication. Most existing schemes for cluster key management use messages exchange among the member nodes within a cluster for the new cluster key establishment when a node leaves or joins a cluster. This causes significant communication and computation costs. Furthermore, the secure distribution of cluster keys among member nodes in frequently changing environments is a difficult task without encryption and decryption operations. For secure cluster key management, we utilized polynomial (P) to accomplish effective intra-cluster key management and produced polynomial for making an inter-cluster key distribution. The main contribution is to generate polynomials and broadcast to nodes whenever a change occurs in a network or demanding nodes for secure key management. The presented scheme supports scalability for an increasing number of nodes using polynomials. The proposed scheme increases the lifetime of the network by decreasing the key pool size

ENT manifestations in HIV infected patients in PIMS Islamabad.

INTRODUCTION HIV is a global pandemic with estimation of 38 million active cases around the world according to WHO HIV data and statistics 2019. Despite of advancement in medical field the disease has not been tamed uptil now. In this modern era HIV is still considered a taboo in Pakistan, people are reluctant about disclosure of disease, screening of their partners and its treatment which is due to lack of awareness and socio-economic constraints. OBJECTIVE The aim of this study is to see the incidence of Ear, Nose and Throat (ENT) manifestations in HIV infected people presented in tertiary care hospital of Islamabad. MATERIAL AND METHOD A one-year observational cross-sectional study conducted in Pakistan Institute of Medical Sciences (PIMS) Islamabad between January 2019 to December 2019. All the HIV infected patients who presented with ear, nose and throat manifestations were recruited in the study. Detailed history and examination were conducted after taking written consent. Analysis included calculations of mean values of quantitative association between ENT symptoms and demographic characteristics. Statistical analysis was estimated using either Chi-square test or t-test.   RESULTS Majority of the patients presented with Otological manifestation of which the most common was chronic suppurative otitis media (14.28%). Most common Rhinological/Oropharyngeal manifestation included epistaxis (12.24%) and oral candidiasis (8.16%) respectively. Among neck manifestations cervical lymph adenopathy (18.16%) showed the highest percentage. CONCLUSION The study shows a local trend of ENT manifestation in which the patient presented in later stage (WHO III) which resembled to the studies carried out in other developing countries showing ineffectiveness of current national HIV/AIDS programme

Secure Cluster-Head Selection Algorithm Using Pattern for Wireless Mobile Sensor Networks

Selecting a cluster head (CH) in wireless mobile sensor network is a crucial task. Numerous algorithms have been presented for this purpose in recent literature. In these algorithms, all nodes are permitted to contend in CH selection process regardless of their less resource. This meaningless participation of ineligible nodes in the CH selection process causes unnecessary communication cost. Similarly the use of real data for CH selection increases communication cost. Additionally, no one algorithm has focus in security aspect of CH selection process. In this article Pattern Based secure CH Selection algorithm has been presented. This algorithm filters the ineligible nodes, puts them to sleep mode thereby restricting them from not participating in the CH selection process. Additionally the uses of pattern instead of real data in CH selection decrease communication cost and increase security of CH selection process. The simulation results show the improvement in lifetime and enhancement in security of CH selection

Succinate Coenzyme A Ligase Beta-Like Protein from Trichinella spiralis Suppresses the Immune Functions of Rat PBMCs In Vitro and Inhibits the Secretions of Interleukin-17 In Vivo

Succinate Coenzyme A ligase beta-like protein (SUCLA-β) is a subunit of Succinyl-coenzyme A synthetase, which is involved in substrate synergism, unusual kinetic reaction in which the presence of SUCLA-β for one partial reaction stimulates another partial reaction. Trichinella spiralis is a parasitic nematode, which may hinder the development of autoimmune diseases. Immunomodulatory effects of SUCLA-β from Trichinella spiralis in the parasite-host interaction are unidentified. In this study the gene encoding T. spiralis SUCLA-β was cloned and expressed. Binding activities of recombinant T. spiralis SUCLA-β (rTs-SUCLA-β) to rat peripheral blood mononuclear cells (PBMCs) were checked by immunofluorescence assay (IFA) and the immuno-regulatory effects of rTs-SUCLA-β on cell migration, cell proliferation, nitric oxide (NO) production and apoptosis were observed by co-incubation of rTs-SUCLA-β with rat PBMCs in vitro, while cytokine secretions in rTs-SUCLA-β treated rats were evaluated in vivo. Furthermore, phagocytosis of monocytes was detected by flow cytometry and effects of rTs-SUCLA-β-induced protective immunity on T. spiralis adult worms and muscle larva were evaluated in rats. The IFA results revealed that rTs-SUCLA-β could bind to rat PBMCs. Treatment of PBMCs with rTs-SUCLA-β significantly decreased the monocyte phagocytosis, cell migration and cell proliferation, while NO production and apoptosis of PBMCs were unaffected. Results of the in vivo study showed that the IL-17 secretion decreased significantly after rTs-SUCLA-β administration in rats, while no significant effects were observed on the secretions of IFN-γ, IL-9, TGF-β and IL-4. Moreover, significant reduction of T. spiralis muscle larvae burden and significant increase in anti-rTs-SUCLA-β immunoglobulin level of IgG, IgG1 and IgG2a was observed in rTs-SUCLA-β-administered rats. The results indicated that rTs-SUCLA-β may be a potential target for controlling T. spiralis infection by suppressing the immune functions of the rat PBMCs and by reducing the parasite burden. Additionally it may also contribute to the treatment of autoimmune diseases and graft rejection by suppressing IL-17 immune response in the host

Multihop system in case of node failure.

<p>Multihop system in case of node failure.</p

System model.

<p>System model.</p