Chloramphenicol therapy of typhoid fever

In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 versus 15.4 +/- 6.1 mcg/ml) chloramphenicol concentrations were comparable in both groups, a significantly wider range was found in the group receiving 100 mg/kg/day. Potentially toxic levels (greater than 30 mcg/ml) developed in two patients with liver dysfunction. Chloramphenicol in a dosage of 75 mg/kg/day is adequate and safe for the treatment of paediatric typhoid

General practitioners\u27 awareness and management of common psychiatric disorders: a community-based survey from Karachi, Pakistan

This study assessed the knowledge and management of common psychiatric disorders by general practitioners (GPs) in Karachi, Pakistan. Structured interviews were carried out in 2009 with 360 GPs selected by cluster random sampling. Patients with psychiatric disorders were estimated to be up to 10% of the daily caseload according to 71.8% of doctors. Two-thirds of GPs were unaware of the ICD-10 diagnostic criteria for depression and anxiety disorders. Benzodiazepines were the most recognized category of medication (75.3%) and were the most commonly used medication for all mental health conditions. Fewer GPs were familiar with selective serotonin reuptake inhibitors (35.1%) or tricyclic antidepressants (20.2%). Lack of time and patients\u27 financial constraints were reported to be barriers to care. Most GPs (69.2%) had not received any recent medical education about mental health problems. Gaps in GPs\u27 knowledge about the management of mental disorders have implications for the rational use of psychotropic medications in primary care

Inter-band B(E2) transition strengths in odd-mass heavy deformed nuclei

Inter-band B(E2) transition strengths between different normal parity bands in 163Dy and 165Er are described using the pseudo-SU(3) model. The Hamiltonian includes Nilsson single-particle energies, quadrupole-quadrupole and pairing interactions with fixed, parametrized strengths, and three extra rotor terms used to fine tune the energy spectra. In addition to inter-band transitions, the energy spectra and the ground state intra-band B(E2) strengths are reported. The results show the pseudo-SU(3) shell model to be a powerful microscopic theory for a description of the normal parity sector in heavy deformed odd-A nuclei.Comment: 4 figures, 2 table

A flexible and pattern reconfigurable antenna with small dimensions and simple layout for wireless communication systems operating over 1.65–2.51 ghz

This research article proposes a compact frequency and pattern reconfigurable flexible antenna for heterogeneous applications. A triangular monopole antenna with a semicircular stub is made frequency and pattern tunable by connecting and disconnecting two inverted L-shaped stubs utilizing diodes. When either of the stubs is connected to the radiator, a relative phase difference happens at both ends of the radiator that changes the direction of the electromagnetic radiations, consequently pattern reconfigurability can be obtain. Besides that, because of the reactive load introduced by the stubs, the antenna's effective length has changed and, as a result, the frequency reconfigurability can be attained. The antenna features a compact size of 40 x 50 x 0.254 mm(3) corresponding to 0.22 lambda(o) x 0.27 lambda(o) x 0.001 lambda(o), where lambda(o) is free-space wavelength at 1.65 GHz, while its operational bandwidth is from 1.65 GHz to 2.51 GHz, with an average gain and radiation efficiency of better than 2.2 dBi and 80%, exhibiting a pattern reconfigurability of 180 degrees in the E-plane. The frequency of the proposed antenna can be switched from 2.1 GHz to 1.8 GHz by switching the state of both diodes in OFF and ON-state, respectively. The fabricated prototype of the antenna is tested to verify its performance parameters. In addition, to validate the proposed design, it has been compared with prior arts in terms of the overall size, reconfigurability type, flexibility, radio frequency (RF) switch type used for reconfigurability, and frequency bandwidth. The proposed antenna provides smaller size with a large bandwidth coverage alongside with discrete RF switch type with the advantages of flexibility and both frequency and pattern reconfigurability. As a result, the proposed compact flexible and pattern reconfigurable antenna is a promising candidate for heterogeneous applications, including the global system for mobile (GSM) band (1800 and 1900 MHz) and industrial, scientific and medical (ISM) band (2.4 GHz) along with well-known cellular communication bands of 3G, 4G, and long term evolution (LTE) bands ranging from 1700-2300 MHz around the globe

Immunohistochemical Estrogen receptor determination in human Breast carcinoma: correlation with histologic differentiation and age of the patients

An immunohistochemical assay for the measurement of estrogen receptor (ER) has been evaluated on 290 consecutive human breast biopsy and mastectomy specimens in the year 1992 at The Aga Khan University Hospital laboratories. Immunohistochemical localization of estrogen receptor on frozen/paraffin section was scored in a semi-quantitative fashion incorporating both the intensity and the distribution of specific staining. Histologic grading of the tumour was performed according to Bloom’s method. In this study, 21% of the tumours were estrogen receptor negative, 15% were weak positive, 25% intermediate positive and 39% strong positive. Fifty percent of the well differentiated tumours showed strong ER positivity against 27% of the poorly differentiated tumours. Seventy eight percent of all negative estrogen receptors were in patients younger than 50 years of age (pre-menopausal group), while 52% of strong estrogen receptor positivity was observed in patients older than 50 years (post- menopausal). This study demonstrates the value of immunohistochemical method to determine the ER status in patients with advanced breast cancer

Study of optical band gap and carbon cluster sizes formed in 100 MeV Si8+ and 145 MeV Ne6+ ions irradiated polypropylene polymer

A wide variety of material modifications in polymers have been studied by using ion irradiation techniques. Extensive research has focused on to Swift Heavy Ions (MeV's energy), probably because of good controllability and the large penetration length in polymers. High energy ion irradiation tends to damage polymers significantly by electronic excitation and ionization. It may result into the creation of latent tracks and can also cause formation of radicals such as ablation, sputtering, chain scission and intermolecular cross-linking, creation of triple bonds and unsaturated bonds and loss volatile fragments. Polypropylene polymer films of thickness 50 μm were irradiated to the fluences of 1 × 1010, 3 × 1010, 1 × 1011, 3 × 1011, 6 × 1011 and 1 × 1012 ions/cm2 with Si8+ ions of 100 MeV energy from Pelletron accelerator at Inter University Accelerator Centre (IUAC), New Delhi and Ne6+ ions of 145 MeV to the fluences of 108, 1010, 1011, 1012 and 1013 ions/cm3 from Variable Energy Cyclotron Centre, Kolkata. Optical modifications were characterized by UV towards the red end of the spectrum with the increase of the fluence. Value of optical band gap Eg shows a decreasing trend with ion fluence irradiated with both kinds of ions. Cluster size N, the number of carbon atoms per conjugation length increases with increasing ion dose. Cluster size also increases with the increase of electronic stopping power.Rajesh Kumar1*, S Asad Ali1, A. H. Naqvi1, H. S. Virk2, Udayan De3, D K Avasthi4 and Rajendra Prasad1 1Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh-202 002, Uttar Pradesh, India 2360 Sector-71, SAS Nagar (Mohali), Chandigarh-160 071, Punjab, India 3Variable Energy Cyclotron Centre, 1/AF, Bidhan Nagar, Kolkata-700 064, India 4Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi-110 067, India E-mail : [email protected] of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh-202 002, Uttar Pradesh, India 2360 Sector-71, SAS Nagar (Mohali), Chandigarh-160 071, Punjab, India Variable Energy Cyclotron Centre, 1/AF, Bidhan Nagar, Kolkata-700 064, India Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi-110 067, Indi

Iron organic speciation during the LOHAFEX experiment: Iron ligands release under biomass control by copepod grazing

The LOHAFEX iron fertilization experiment consisted in the fertilization of the closed core of a cyclonic eddy located south of the Antarctic Polar Front in the Atlantic sector of the Southern Ocean. This eddy was characterized by high nitrate and low silicate concentrations. Despite a 2.5 fold increase of the chlorophyll-a (Chl-a) concentrations, the composition of the biological community did not change. Phytoplankton biomass was mostly formed by small autotrophic flagellates whereas zooplankton biomass was mostly comprised by the large copepod Calanus simillimus. Efficient recycling of copepod fecal pellets (the main component of the downward flux of organic matter) in the upper 100–150 m of the water column prevented any significant deep export of particulate organic carbon (POC). Before fertilization, dissolved iron (DFe) concentrations in the upper 200 m were low, but not depleted, at ~0.2 nM. High DFe concentrations appeared scattered from day 14 onwards as a result of the grazing activity. A second fertilization on day 21 had no significant effect on the DFe and Chl-a standing stocks. Work with unfiltered samples using different acidification protocols revealed that, by midway of LOHAFEX, rapid recycling of iron-replenished copepod fecal pellets explained the source of bioavailable iron that prolonged the duration of the bloom for many weeks. Here we present the evolution of the organic speciation of iron in the upper 200 m of the water column during LOHAFEX by a Competing Ligand Equilibrium method using voltammetry. During the first 12 days of the experiment, ligands of an affinity for iron similar to the ligands found before fertilization (logK′Fe′L~11.9) accumulated in fertilized waters mostly in the upper 80 m (from ~1 nM to ~2.5 nM). The restriction of ligand accumulation to the depth of Chl-a penetration points to exudation by the growing autotrophic population as the initial source of ligands. From day 5 onwards, we found in many samples a new class of ligands (L1) characterized by a significant higher conditional stability constant than the background complexation (logK′Fe′L1~12.9). During the middle section of the experiment (days 12 to 25) the accumulation of overall ligands and specifically L1, reached an upper limit in surface waters (at ~3 nM). Overall ligands and L1 accumulation was also observed below the mixed layer depth indicating that grazing was the process behind ligand release. During the last 10 days of the experiment ligands kept accumulating in deep waters but suffered a small decrease in the upper 50 m of the water column caused by the vanishing of L1. Ligand removal restricted to the euphotic layer was probably caused by photodegradation. A high correlation between [DFe] and [L1] suggested that recycled iron (released during grazing and copepod fecal pellet cycling) was in the form of FeL1 complexes. We hypothesize that the iron binding ligands released to the dissolved phase during LOHAFEX were mostly photosensitive intracellular ligands rapidly degraded in extracellular conditions (e.g.: pigments). Sloppy feeding by copepods and recycling of cells and cellular material in copepod fecal pellets caused the transfer of particulate ligands to the dissolved phase as zooplankton built up as a response to the blooming community