«Domum construi praecepi». Qualche aggiunta su Santa Maria di Mili

As an introduction to a new interpretation of the Abbey of Santa Maria in Mili, a village a few miles south of Messina, this paper aims to reconsider the surviving witnesses of its Greek foundation document. This document was granted to the abbot Michele by Count Roger I, probably at the end of the XI century. In addition to the two well-known Latin witnesses which have been recently published by Julia Becker, I have discovered two other (Latin and Italian) witnesses. This new evidence has allowed me to reconsider some pivotal matters, such as the document’s authenticity, its date of issue and the reasons behind the two Latin translations. The examination of those newly found copies has clarified the information given by the XVII century Sicilian savants scholars concerning the foundation of the monastery, its alleged pre-Norman existence and the assumption that the existing church is what remains of the XI century buildings mentioned in the text. The translation of the only previously unpublished witness is provided in the appendix.L’articolo riesamina, come premessa a una nuova lettura del monumento, i testimoni pervenutici del diploma di fondazione in lingua greca dell’abbazia di Santa Maria di Mili, a sud di Messina, concesso, probabilmente alla fine del secolo XI, da Ruggero I all’abate Michele. Oltre a due testimoni latini ben noti e pubblicati qualche anno fa da Julia Becker, sono stati rintracciati altri due testimoni, l’uno latino e l’altro volgare, che hanno sollecitato qualche nuova considerazione in merito all’autenticità del privilegio, alla data della sua concessione e alle ragioni delle due diverse traduzioni latine; e qualche chiarimento su quanto ci è stato tramandato in merito alla fondazione dell’abbazia dagli eruditi secenteschi, sulla presunta fase prenormanna del cenobio, sull’opportunità di ancorare le attuali fabbriche monastiche ad alcuni indizi di strutture chiesastiche presenti nel testo. L’articolo è seguito, in appendice, da una prima trascrizione dell’unico dei testimoni ancora inedito

The first ASIC prototype of a 28 nm time-space front-end electronics for real-time tracking

A front-end ASIC for 4D tracking is presented. The prototype includes the block necessary to build a pixel front-end chain for timing measurement, as independent circuits. The architecture includes a charge-sensitive amplifier, a discriminator with programmable threshold, and a time- to-digital converter. The blocks were designed with target specifications in mind including: an area occupation of 55 μm × 55 μm, a power consumption tens of micro ampere per channel and timing a resolution of at least 100 ps. The prototype has been designed and integrated in 28 nm CMOS technology. The presented design is part of the TimeSpOT project which aims to reach a high-resolution particle tracking both in space and in time, in order to provide front-end circuitry suitable for next generation colliders

The Exponential Phase of the Covid-19 Pandemic in Central Italy: An Integrated Care Pathway

The Coronavirus Disease (Covid-19) pandemic is rapidly spreading across the world, representing an unparalleled challenge for health care systems. There are differences in the estimated fatality rates, which cannot be explained easily. In Italy, the estimated case fatality rate was 12.7% in mid-April, while Germany remained at 1.8%. Moreover, it is to be noted that different areas of Italy have very different lethality rates. Due to the complexity of Covid-19 patient management, it is of paramount importance to develop a well-defined clinical workflow in order to avoid the inconsistent management of patients. The Integrated Care Pathway (ICP) represents a multidisciplinary outline of anticipated care to support patient management in the Sant’Andrea Hospital, Rome. The main objective of this pilot study was to develop a new ICP evaluated by care indicators, in order to improve the COVID-19 patient management. The suggested ICP was developed by a multi-professional team composed of different specialists and administrators already involved in clinical and management processes. After a review of current internal practices and published evidences, we identified (1) the activities performed during care delivery, (2) the responsibilities for these activities, (3) hospital structural adaptation needs and potential improvements, and (4) ICP indicators. The process map formed the basis of the final ICP document; 160 COVID-19 inpatients were considered, and the effect of the ICP implementation was evaluated over time during the exponential phase of the COVID-19 pandemic. In conclusion, a rapid adoption of ICP and regular audits of quality indicators for the management of COVID-19 patients might be important tools to improve the quality of care and outcomes

Metagenomics in ophthalmology: current findings and future prospectives.

Less than 1% of all microorganisms of the available environmental microbiota can be cultured with the currently available techniques. Metagenomics is a new methodology of high-throughput DNA sequencing, able to provide taxonomic and functional profiles of microbial communities without the necessity to culture microbes in the laboratory. Metagenomics opens to a 'hypothesis-free' approach, giving important details for future research and treatment of ocular diseases in ophthalmology, such as ocular infection and ocular surface diseases

Metagenomics in ophthalmology: current findings and future prospectives.

Less than 1% of all microorganisms of the available environmental microbiota can be cultured with the currently available techniques. Metagenomics is a new methodology of high-throughput DNA sequencing, able to provide taxonomic and functional profiles of microbial communities without the necessity to culture microbes in the laboratory. Metagenomics opens to a 'hypothesis-free' approach, giving important details for future research and treatment of ocular diseases in ophthalmology, such as ocular infection and ocular surface diseases

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

1. Incorporation of a nitric oxide (NO)-releasing moiety in aspirin can overcome its gastric side effects. 2. We investigated the NO-release patterns and antiplatelet effects of novel furoxan derivatives of aspirin (B8 and B7) in comparison to existing antiplatelet agents. 3. Cyclooxygenase (COX) activity was investigated in purified enzyme using an electron paramagnetic resonance-based technique. Concentration–response curves for antiplatelet agents±the soluble guanylate cyclase inhibitor, ODQ (50 μM) were generated in platelet-rich plasma (PRP) and washed platelets (WP) activated with collagen using turbidometric aggregometry. NO was detected using an isolated NO electrode. 4. The furoxan derivatives of aspirin (B8, B7) and their NO-free furazan equivalents (B16, B15; all 100 μM) significantly inhibited COX activity (P<0.01; n=6) in vitro and caused aspirin-independent, cGMP-dependent inhibition of collagen-induced platelet aggregation in WP. B8 was more potent than B7 (PRP IC(50)=0.62±0.1 μM for B8; 400±89 μM for B7; P<0.0001. WP IC(50)s=0.6±0.1 and 62±10 μM, respectively). The NO-free furazan counterparts were less potent antiplatelet agents (WP IC(50)s=54±3 μM and 62±10 μM, respectively; P<0.0001, B8 vs B16). Of the hybrids investigated, only B8 retained antiplatelet activity in PRP. 5. NO release from furoxan–aspirin hybrids was undetectable in buffer alone, but was accelerated in the presence of either plasma or plasma components, albumin (4%), glutathione (GSH; 3 μM) and ascorbate (50 μM), the effects of which were additive for B7 but not B8. NO generation from furoxans was greatly enhanced by platelet extract, an effect that could largely be explained by the synergistic effect of intracellular concentrations of GSH (3 mM) and ascorbate (1 mM). 6. We conclude that the decomposition of furoxan–aspirin hybrids to generate biologically active NO is catalysed by endogenous agents which may instil a potential for primarily intracellular delivery of NO. The blunting of the aspirin effects of furoxan hybrids is likely to be due to loss of the acetyl moiety in plasma; the observed antiplatelet effects are thereby primarily mediated via NO release. Compounds of this class might represent a novel means of inhibiting platelet aggregation by a combination of NO generation and COX inhibition

livingstreet

il testo \ue8 la restituzione di una ricerca applicata sulle tecniche per la trasformazione dell'infrastruttura da spazio tecnico a spazio abitat

Masterplan 2. La Riva San Vito di Marano Lagunare Boulevard tra terra e acqua

La laguna, i canneti, i canali, la gronda, le barene, l’acqua bassa e gli isolotti attorno disegnano un mondo “fortemente naturale” che è stato nella storia di questi luoghi, tra Marano e la sua Laguna, unico e obbligato riferimento per la vita urbana, ma anche modello per l’architettura e motivo della forma urbis. E così il paesaggio, nelle sue forme e figure, qualità e consistenze, dimensioni e profondità è diventato nel corso del tempo materia e legame del tessuto edilizio e urbano maranese. Ma la forma forse più emblematica in cui si incarna questa dimensione paesaggistica sta in quei materiali urbani liminari, quelli che mediamo il passaggio tra il suolo di terra e quello di acqua: le rive. E la Riva San Vito, oggetto di questo studio, è proprio uno di questi luoghi. È un brano significativo del paesaggio terracqueo. Da questa particolare e ambivalente natura dei luoghi traggono origine tutti gli studi e le riflessioni che presentiamo in questa pubblicazione, ma anche e soprattutto gli obiettivi del masterplan: la trasformazione e ridefinizione in una sequenza articolata e aperta a usi misti e condivisi dello spazio pubblico e di quello stradale assieme a quello tecnico e di servizio degli approdi, i rifugi di pesca. Questo studio prefigura un nuovo spazio urbano in grado di accogliere aree di lavoro legate alla pesca e all’ormeggio delle imbarcazioni, sedi per flussi diversificati, spazi pubblici e aree attrezzate per la sosta, il tempo libero e per il turismo. E così attraverso osservazioni, indagini alle diverse scale e su diversi materiali, simulazioni e ipotesi di trasformazione, immagini di possibili futuri urbani, la Riva San Vito viene qui proposta come una nuova “passeggiata lungolaguna”, un Boulevard lagunare sospeso tra terra e acqua, tra costa e laguna, tra storia millenaria e quotidiana contemporaneità di naviganti lagunari e di pescatori.The lagoon, the reeds, the canals, the eaves, the sandbanks, the shallow water and the islets draw a strongly natural world that has been in the history of these places, between Marano and its lagoon. A single reference for urban life, but also a model for architecture and the forma urbis. The most emblematic form in which this landscape dimension is embodied lies in those liminal urban materials, those that mediate the passage between the soil of earth and the water. The Riva San Vito, subject of this study, is precisely one of these places. It is a significant piece of the earthly landscape. This study foreshadows a new urban space to accommodate work spaces for fishing and the mooring of boats, space for flows, public spaces and rest areas, leisure and tourism. Through observations, investigations at different scales and on different materials, with simulations and images of possible urban futures, the Riva San Vito is proposed here as a new "lakeside promenade", a lagoon boulevard suspended between land and water, between coast and lagoon, between millenary history and the daily contemporaneity of lagoon sailors and fishermen